{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050020984037640960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"https://hdl.handle.net/11094/98545"}},{"identifier":{"@type":"DOI","@value":"10.1126/sciadv.adp2357"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/sciadv.adp2357"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Mechano-gradients drive morphogen-noise correction to ensure robust patterning"}],"dc:language":"en","description":[{"type":"Other","notation":[{"@language":"en","@value":"Aoki Kana, Higuchi Taiki, Akieda Yuki, et al. Mechano-gradients drive morphogen-noise correction to ensure robust patterning. Science Advances 10, 337 (2024); https://doi.org/10.1126/sciadv.adp2357."}]},{"type":"Other","notation":[{"@language":"en","@value":"Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, the roles and regulation of the physical communication between morphogen-receiver cells remain unclear. Here, we show that the Wnt/β-catenin–morphogen gradient, which patterns the embryonic anterior-posterior (AP) axis, generates intercellular tension gradients along the AP axis by controlling membrane cadherin levels in zebrafish embryos. This “mechano-gradient” is used for the cell competition–driven correction of noisy morphogen gradients. Naturally and artificially generated unfit cells, producing noisy Wnt/β-catenin gradients, induce local deformation of the mechano-gradients that activate mechanosensitive calcium channels in the neighboring fit cells, which then secrete annexin A1a to kill unfit cells. Thus, chemo-mechanical interconversion–mediated competitive communication between the morphogen-receiver cells ensures precise tissue patterning."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070020984037640964","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Aoki, Kana"}]},{"@id":"https://cir.nii.ac.jp/crid/1070020984037640965","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Higuchi, Taiki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326229912064","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20770514"},{"@type":"NRID","@value":"1000020770514"},{"@type":"NRID","@value":"9000411586793"},{"@type":"NRID","@value":"9000402399005"},{"@type":"NRID","@value":"9000322734599"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/akieda"}],"foaf:name":[{"@language":"en","@value":"Akieda, Yuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1070020984037640963","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Matsubara, 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