Host-Guest Interaction-Controlled Site-selective C–H Borylation of Aromatic Compounds

機関リポジトリ (HANDLE) オープンアクセス
  • Su, Haotian
    九州大学大学院総合理工学府総合理工学専攻
  • 國信, 洋一郎
    九州大学先導物質化学研究所 九州大学大学院総合理工学研究院総合理工学専攻

説明

The site-selective transformation of aromatic compounds remains a challenge in organic synthesis. Conventional methods for controlling site-selectivity often use directing groups, which limit substrate availability owing to the need for coordinating functional groups. Herein, we report a strategy in which the cyclic moiety of a catalyst recognizes and traps the substrate via host-guest interaction between the catalyst and substrate, allowing the catalytically active site to preferentially approach the desired reaction site, thereby enabling site-selective reactions. This catalyst can be used to control the site-selectivity of substrates that lack functional groups, which are essential in conventional methods. These results have the potential to extend the substrate scope and provide new catalyst designs for carbon–hydrogen bond transformations.

収録刊行物

  • ChemRxiv

    ChemRxiv 2025-03-14

    Cambridge University Press

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詳細情報 詳細情報について

  • CRID
    1050022457824840704
  • ISSN
    25732293
  • HANDLE
    2324/7347379
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB

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