Hair follicle stem cell progeny heal blisters while pausing skin development

DOI DOI IR (HANDLE) HANDLE Web Site View 5 Remaining Hide 8 Citations 84 References Open Access

Bibliographic Information

Published
2021-07-05
Resource Type
journal article
DOI
  • 10.1101/2020.04.08.032326
  • 10.15252/embr.202050882
Publisher
EMBO Press

Search this article

Description

Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases.

Journal

  • EMBO Reports

    EMBO Reports 22 (7), e50882-, 2021-07-05

    EMBO Press

Citations (8)*help

See more

References(84)*help

See more

Related Projects

See more

Keywords

Report a problem

Back to top