Opposing Role of NMDA Receptor GluN2B and GluN2D in Somatosensory Development and Maturation

DOI IR (HANDLE) Web Site PubMed 7 Citations 63 References Open Access

Bibliographic Information

Other Title
  • Opposing role of NMDA receptor GluN2B and GluN2D in somatosensory development and maturati
Published
2014-08-27
Resource Type
journal article
Rights Information
  • Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
DOI
  • 10.1523/jneurosci.1811-14.2014
Publisher
Society for Neuroscience

Search this article

Description

Development of correct topographical connections between peripheral receptors and central somatosensory stations requires activity-dependent synapse refinement, in which the NMDA type of glutamate receptors plays a key role. Here we compared functional roles of GluN2B (GluR epsilon 2 or NR2B) and GluN2D (GluR epsilon 4 or NR2D), two major regulatory subunits of neonatal NMDA receptors, in development of whisker-related patterning at trigeminal relay stations. Compared with control littermates, both the appearance of whisker-related patterning and the termination of the critical period, as assessed by unilateral infraorbital nerve transection, were delayed by nearly a day in the somatosensory cortex of GluN2B(+/-) mice but advanced by nearly a day in GluN2D(-/-) mice. Similar temporal shifts were found at subcortical relay stations in the thalamus and brainstem of GluN2B(+/-) and GluN2D(-/-) mice. In comparison, the magnitude of lesion-induced critical period plasticity in the somatosensory cortex, as assessed following row-C whisker removal, was normal in both mutants. Thus, GluN2B and GluN2D play counteractive roles in temporal development and maturation of somatosensory maps without affecting the magnitude of critical period plasticity. To understand the opposing action, we then examined neuronal and synaptic expressions of the two subunits along the trigeminal pathway. At each trigeminal station, GluN2B was predominant at asymmetrical synapses of non-GABAergic neurons, whereas GluN2D was selective to asymmetrical synapses of GABAergic neurons. Together, our findings suggest that GluN2B expressed at glutamatergic synapses on glutamatergic projection neurons facilitates refinement of ascending pathway synapses directly, whereas GluN2D expressed at glutamatergic synapses on GABAergic interneurons delays it indirectly.

Journal

Citations (7)*help

See more

References(63)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top