{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050282677594771328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2241/113249"}},{"identifier":{"@type":"URI","@value":"https://tsukuba.repo.nii.ac.jp/records/24569"}},{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m109.057745"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S002192581954995X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S002192581954995X?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M109.057745"}},{"identifier":{"@type":"PMID","@value":"20089855"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"cAMP-response Element-binding Protein (CREB) Controls MSK1-mediated Phosphorylation of Histone H3 at the c-fos Promoter in Vitro"}],"dc:language":"en","description":[{"notation":[{"@value":"The rapid induction of the c-fos gene correlates with phosphorylations of histone H3 and HMGN1 by mitogen- and stress-activated protein kinases. We have used a cell-free system to dissect the mechanism by which MSK1 phosphorylates histone H3 within the c-fos chromatin. Here, we show that the reconstituted c-fos chromatin presents a strong barrier to histone H3 phosphorylation by MSK1; however, the activators (serum response factor, Elk-1, cAMP-response element-binding protein (CREB), and ATF1) bound on their cognate sites recruit MSK1 to phosphorylate histone H3 at Ser-10 within the chromatin. This activator-dependent phosphorylation of histone H3 is enhanced by HMGN1 and occurs preferentially near the promoter region. Among the four activators, CREB plays a predominant role in MSK1-mediated phosphorylation of histone H3, and the phosphorylation of Ser-133 in CREB is essential for this process. Mutational analyses of MSK1 show that its N-terminal inhibition domain is critical for the kinase to phosphorylate chromatin-embedded histone H3 in a CREB-dependent manner, indicating the presence of an intricate regulatory network for MSK1-mediated phosphorylation of histone H3."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326210540800","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50383287"},{"@type":"NRID","@value":"1000050383287"},{"@type":"NRID","@value":"9000413529786"},{"@type":"NRID","@value":"9000413525173"},{"@type":"NRID","@value":"9000002550903"},{"@type":"NRID","@value":"9000413519453"},{"@type":"NRID","@value":"9000413489574"},{"@type":"NRID","@value":"9000000448980"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/3030msms"}],"foaf:name":[{"@language":"en","@value":"Shimada Miho"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276170572288","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10364770"},{"@type":"NRID","@value":"1000010364770"},{"@type":"NRID","@value":"9000413529785"},{"@type":"NRID","@value":"9000413525174"},{"@type":"NRID","@value":"9000413519451"},{"@type":"NRID","@value":"9000413489575"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/TomoN"}],"foaf:name":[{"@language":"en","@value":"Nakadai Tomoyoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751162974720","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50436276"},{"@type":"NRID","@value":"1000050436276"},{"@type":"NRID","@value":"9000361296860"},{"@type":"NRID","@value":"9000408649732"},{"@type":"NRID","@value":"9000002531377"},{"@type":"NRID","@value":"9000413529784"},{"@type":"NRID","@value":"9000240044187"},{"@type":"NRID","@value":"9000413525172"},{"@type":"NRID","@value":"9000364402186"},{"@type":"NRID","@value":"9000413519452"},{"@type":"NRID","@value":"9000004411818"},{"@type":"NRID","@value":"9000413489576"},{"@type":"NRID","@value":"9000413523296"},{"@type":"NRID","@value":"9000004658616"},{"@type":"NRID","@value":"9000413480381"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000027948"}],"foaf:name":[{"@language":"en","@value":"FUKUDA AYA"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276177053696","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70271236"},{"@type":"NRID","@value":"1000070271236"},{"@type":"NRID","@value":"9000381069456"},{"@type":"NRID","@value":"9000000853945"},{"@type":"NRID","@value":"9000413529783"},{"@type":"NRID","@value":"9000413529787"},{"@type":"NRID","@value":"9000413503993"},{"@type":"NRID","@value":"9000413525176"},{"@type":"NRID","@value":"9000364245781"},{"@type":"NRID","@value":"9000007157402"},{"@type":"NRID","@value":"9000413512478"},{"@type":"NRID","@value":"9000413512471"},{"@type":"NRID","@value":"9000413519455"},{"@type":"NRID","@value":"9000413473568"},{"@type":"NRID","@value":"9000414381955"},{"@type":"NRID","@value":"9000413489573"},{"@type":"NRID","@value":"9000413489577"},{"@type":"NRID","@value":"9000413523298"},{"@type":"NRID","@value":"9000000558671"},{"@type":"NRID","@value":"9000413480383"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0186281"}],"foaf:name":[{"@language":"en","@value":"HISATAKE Koji"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"},{"@type":"NCID","@value":"AA00251083"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"American Society for Biochemistry and Molecular Biology"},{"@value":"Elsevier"}],"prism:publicationDate":"2010-03-01","prism:volume":"285","prism:number":"13","prism:startingPage":"9390","prism:endingPage":"9401"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["This research was originally published in The journal of biological chemistry. Shimada M; Nakadai T; Fukuda A; Hisatake K. cAMP-response Element-binding Protein (CREB) Controls MSK1-mediated Phosphorylation of Histone H3 at the c-fos Promoter in Vitro. The journal of biological chemistry. 2010. 285:9390-9401. \n(c) the American Society for Biochemistry and Molecular Biology"],"url":[{"@id":"https://tsukuba.repo.nii.ac.jp/records/24569"},{"@id":"https://api.elsevier.com/content/article/PII:S002192581954995X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S002192581954995X?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M109.057745"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Genetic","dc:title":"Models, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Mutational%20Analysis","dc:title":"DNA Mutational Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Ribosomal%20Protein%20S6%20Kinases,%2090-kDa","dc:title":"Ribosomal Protein S6 Kinases, 90-kDa"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatin","dc:title":"Chromatin"},{"@id":"https://cir.nii.ac.jp/all?q=Histones","dc:title":"Histones"},{"@id":"https://cir.nii.ac.jp/all?q=Serine","dc:title":"Serine"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Regulatory%20Networks","dc:title":"Gene Regulatory Networks"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclic%20AMP%20Response%20Element-Binding%20Protein","dc:title":"Cyclic AMP Response Element-Binding Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20c-fos","dc:title":"Proto-Oncogene Proteins c-fos"},{"@id":"https://cir.nii.ac.jp/all?q=HeLa%20Cells","dc:title":"HeLa Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Plasmids","dc:title":"Plasmids"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202633751296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The RNA Binding Complexes NF45-NF90 and NF45-NF110 Associate Dynamically with the c-fos Gene and Function as Transcriptional Coactivators"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757416886528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two target gene activation pathways for orphan ERR nuclear receptors"}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:00843:0001615854"},{"@type":"CROSSREF","@value":"10.1074/jbc.m109.057745"},{"@type":"OPENAIRE","@value":"doi_dedup___::9163a38e1b2783ee7aa8a77faf99d437"},{"@type":"OPENAIRE","@value":"jairo_______::2542fc149a57eaa2ce75a950dc4c3294"},{"@type":"CROSSREF","@value":"10.1074/jbc.m115.688317_references_DOI_DboELdjAJZUzA0kJmr1OMyxKXbJ"},{"@type":"CROSSREF","@value":"10.1038/s41422-022-00774-z_references_DOI_DboELdjAJZUzA0kJmr1OMyxKXbJ"}]}