{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050282677762982016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"URI","@value":"http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-0258851X-20-645"}},{"identifier":{"@type":"NAID","@value":"120005518450"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells"}],"dc:language":"en","description":[{"type":"Other","notation":[{"@value":"type:text"}]},{"type":"Other","notation":[{"@value":"Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells."}]},{"type":"Other","notation":[{"@value":"5p."}]},{"type":"Other","notation":[{"@value":"identifier:JOS-0258851X-20-645"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070282677762982146","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968798"}],"foaf:name":[{"@value":"Barath, Zoltan"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282677762982021","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968799"}],"foaf:name":[{"@value":"Radics, Rita"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282677762982020","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968800"}],"foaf:name":[{"@value":"Spengler, Gabriella"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282677762982144","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968801"}],"foaf:name":[{"@value":"Ocsovszki, Imre"}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608675859328","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20112641"},{"@type":"NRID","@value":"1000020112641"},{"@type":"NRID","@value":"9000254680242"},{"@type":"NRID","@value":"9000272965544"},{"@type":"NRID","@value":"9000254701428"},{"@type":"NRID","@value":"9000272965612"},{"@type":"NRID","@value":"9000272965686"},{"@type":"NRID","@value":"9000254219604"},{"@type":"NRID","@value":"9000272968794"},{"@type":"NRID","@value":"9000254716230"},{"@type":"NRID","@value":"9000337092100"},{"@type":"NRID","@value":"9000006680245"},{"@type":"NRID","@value":"9000005283703"},{"@type":"NRID","@value":"9000377373763"},{"@type":"NRID","@value":"9000272965124"},{"@type":"NRID","@value":"9000254715624"},{"@type":"NRID","@value":"9000254713250"},{"@type":"NRID","@value":"9000002313792"},{"@type":"NRID","@value":"9000272968767"},{"@type":"NRID","@value":"9000272965123"},{"@type":"NRID","@value":"9000272965592"},{"@type":"NRID","@value":"9000347317948"},{"@type":"NRID","@value":"9000009547367"},{"@type":"NRID","@value":"9000254686355"},{"@type":"NRID","@value":"9000018308019"},{"@type":"NRID","@value":"9000410614695"},{"@type":"NRID","@value":"9000254716755"},{"@type":"NRID","@value":"9000272965604"},{"@type":"NRID","@value":"9000388492375"},{"@type":"NRID","@value":"9000005158623"},{"@type":"NRID","@value":"9000284635920"},{"@type":"NRID","@value":"9000020339950"},{"@type":"NRID","@value":"9000396112658"},{"@type":"NRID","@value":"9000257699559"},{"@type":"NRID","@value":"9000272965131"},{"@type":"NRID","@value":"9000252798827"},{"@type":"NRID","@value":"9000254714505"},{"@type":"NRID","@value":"9000254717383"},{"@type":"NRID","@value":"9000273034771"},{"@type":"NRID","@value":"9000241893681"},{"@type":"NRID","@value":"9000272968802"},{"@type":"NRID","@value":"9000340449921"},{"@type":"NRID","@value":"9000402399254"},{"@type":"NRID","@value":"9000005203323"},{"@type":"NRID","@value":"9000005205916"},{"@type":"NRID","@value":"9000413845762"},{"@type":"NRID","@value":"9000242754280"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/masami-0815"}],"foaf:name":[{"@value":"河瀬, 雅美"}]},{"@id":"https://cir.nii.ac.jp/crid/1070001202786663810","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005175893"}],"foaf:name":[{"@value":"本橋, 登"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282677762982019","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968804"}],"foaf:name":[{"@value":"白瀧, 義明"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282677762982145","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968805"}],"foaf:name":[{"@value":"Shah, Anamik"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282677762982017","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000272968806"}],"foaf:name":[{"@value":"Molnar, Jozsef"}]}],"publication":{"publicationIdentifier":[{"@type":"ISSN","@value":"0258851X"},{"@type":"NCID","@value":"AA10714348"}],"prism:publicationName":[{"@value":"In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research"}],"dc:publisher":[{"@value":"International Institute of Anticancer Research"}],"prism:publicationDate":"2006-09","prism:volume":"20","prism:number":"5","prism:startingPage":"645","prism:endingPage":"649"},"url":[{"@id":"http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-0258851X-20-645"}],"createdAt":"2006-07-07","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Formylchromones","dc:title":"Formylchromones"},{"@id":"https://cir.nii.ac.jp/all?q=multidrug%20resistance-reversing%20effect","dc:title":"multidrug resistance-reversing effect"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@value":"Formylchromones"}]},{"subjectScheme":"Other","notation":[{"@value":"multidrug resistance-reversing effect"}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01308:0000775922"},{"@type":"CIA","@value":"120005518450"}]}