老化促進モデルマウス(SAMP6)における骨格筋重量の加齢変化

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  • Age-Related Changes in Skeletal Muscle Weight of Senescence Accelerated Mice (SAMP6)

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Age-related changes in skeletal muscle weight， body weight and internal organ weight were studied in 20， 40， 50 and 60-weeks-old senescence accelerated mice (SAMP6). The mices' body weight increased up to 10 weeks extremely. Thereafter， a continuous increase of body weight was noted with age. The relative heart weight and the relative kidney weight in 60-weeks old were significantly lower than those in 40-weeks-old. The relative muscle weight of the plantaris in 60-weeks-old was significantly lower than that of 20-weeks-old. These results indicate that the relative hindlimb muscle weights decrease with aging in SAMP6.

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