{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050282810694849536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/141829"}},{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1018487108"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1018487108"}},{"identifier":{"@type":"DOI","@value":"10.5167/uzh-50435"}},{"identifier":{"@type":"PMID","@value":"21464321"}},{"identifier":{"@type":"NAID","@value":"120003072120"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway."}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs processing involves the Fanconi anemia (FA) pathway and homologous recombination. Stalled replication forks activate the eight-subunit FA core complex, which ubiquitylates FANCD2-FANCI. Once it is posttranslationally modified, this heterodimer recruits downstream members of the ICL repairosome, including the FAN1 nuclease. However, ICL processing has been shown to also involve MUS81-EME1 and XPF-ERCC1, nucleases known to interact with SLX4, a docking protein that also can bind another nuclease, SLX1. To investigate the role of SLX4 more closely, we disrupted the SLX4 gene in avian DT40 cells. SLX4 deficiency caused cell death associated with extensive chromosomal aberrations, including a significant fraction of isochromatid-type breaks, with sister chromatids broken at the same site. SLX4 thus appears to play an essential role in cell proliferation, probably by promoting the resolution of interchromatid homologous recombination intermediates. Because ubiquitylation plays a key role in the FA pathway, and because the N-terminal region of SLX4 contains a ubiquitin-binding zinc finger (UBZ) domain, we asked whether this domain is required for ICL processing. We found that SLX4(-/-) cells expressing UBZ-deficient SLX4 were selectively sensitive to ICL-inducing agents, and that the UBZ domain was required for interaction of SLX4 with ubiquitylated FANCD2 and for its recruitment to DNA-damage foci generated by ICL-inducing agents. Our findings thus suggest that ubiquitylated FANCD2 recruits SLX4 to DNA damage sites, where it mediates the resolution of recombination intermediates generated during the processing of ICLs."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070282810694849542","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kobayashi, Shunsuke"},{"@language":"ja","@value":"小林, 俊介"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282810694849541","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000024268870"}],"foaf:name":[{"@language":"en","@value":"Kono, Koichi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146080640","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00342840"},{"@type":"NRID","@value":"1000000342840"},{"@type":"NRID","@value":"9000237870127"},{"@type":"NRID","@value":"9000391959803"},{"@type":"NRID","@value":"9000017387713"},{"@type":"NRID","@value":"9000408426639"},{"@type":"NRID","@value":"9000389553479"},{"@type":"NRID","@value":"9000412400844"},{"@type":"NRID","@value":"9000023353626"},{"@type":"NRID","@value":"9000024686099"},{"@type":"NRID","@value":"9000411495301"},{"@type":"NRID","@value":"9000242578731"},{"@type":"NRID","@value":"9000024759942"},{"@type":"NRID","@value":"9000398647279"},{"@type":"NRID","@value":"9000314079120"},{"@type":"NRID","@value":"9000388538399"},{"@type":"NRID","@value":"9000014135736"},{"@type":"NRID","@value":"9000014216323"},{"@type":"NRID","@value":"9000330332100"},{"@type":"NRID","@value":"9000408682026"},{"@type":"NRID","@value":"9000411517670"},{"@type":"NRID","@value":"9000365497572"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/khirota"}],"foaf:name":[{"@language":"en","@value":"Hirota, Kouji"},{"@language":"ja","@value":"廣田, 耕志"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751135560704","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00734104"},{"@type":"NRID","@value":"1000000734104"},{"@type":"NRID","@value":"9000404821460"},{"@type":"NRID","@value":"9000408426619"},{"@type":"NRID","@value":"9000412400845"},{"@type":"NRID","@value":"9000410470960"},{"@type":"NRID","@value":"9000024268852"},{"@type":"NRID","@value":"9000410471992"},{"@type":"NRID","@value":"9000410919480"},{"@type":"NRID","@value":"9000398647259"},{"@type":"NRID","@value":"9000406198818"},{"@type":"NRID","@value":"9000410919487"},{"@type":"NRID","@value":"9000408682023"},{"@type":"NRID","@value":"9000411517669"},{"@type":"NRID","@value":"9000414526195"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000009536"}],"foaf:name":[{"@language":"en","@value":"Tsuda, Masataka"},{"@language":"ja","@value":"津田, 雅貴"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801212611328","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80300870"},{"@type":"NRID","@value":"1000080300870"},{"@type":"CINII_AUTHOR_ID","@value":"DA0943907X"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA0943907X#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA0943907X"},{"@type":"NRID","@value":"9000002737639"},{"@type":"NRID","@value":"9000019140141"},{"@type":"NRID","@value":"9000337098248"},{"@type":"NRID","@value":"9000402818349"},{"@type":"NRID","@value":"9000283149750"},{"@type":"NRID","@value":"9000278466338"},{"@type":"NRID","@value":"9000359946998"},{"@type":"NRID","@value":"9000259303809"},{"@type":"NRID","@value":"9000402125302"},{"@type":"NRID","@value":"9000303641463"},{"@type":"NRID","@value":"9000303641339"},{"@type":"NRID","@value":"9000399551499"},{"@type":"NRID","@value":"9000024970710"},{"@type":"NRID","@value":"9000024268859"},{"@type":"NRID","@value":"9000414924735"},{"@type":"NRID","@value":"9000010460971"},{"@type":"NRID","@value":"9000383214918"},{"@type":"NRID","@value":"9000402594204"},{"@type":"NRID","@value":"9000006145944"},{"@type":"NRID","@value":"9000006488405"},{"@type":"NRID","@value":"9000411520517"},{"@type":"NRID","@value":"9000408897219"},{"@type":"NRID","@value":"9000356894005"},{"@type":"NRID","@value":"9000237871267"},{"@type":"NRID","@value":"9000399258935"},{"@type":"NRID","@value":"9000409332794"},{"@type":"NRID","@value":"9000411203041"},{"@type":"NRID","@value":"9000398998515"},{"@type":"NRID","@value":"9000375897218"},{"@type":"NRID","@value":"9000359883262"},{"@type":"NRID","@value":"9000397707639"},{"@type":"NRID","@value":"9000395364930"},{"@type":"NRID","@value":"9000370759210"},{"@type":"NRID","@value":"9000303640555"},{"@type":"NRID","@value":"9000303638463"},{"@type":"NRID","@value":"9000413518712"},{"@type":"NRID","@value":"9000377370676"},{"@type":"NRID","@value":"9000253174494"},{"@type":"NRID","@value":"9000399228796"},{"@type":"NRID","@value":"9000398031887"},{"@type":"NRID","@value":"9000289265461"},{"@type":"NRID","@value":"9000001077354"},{"@type":"NRID","@value":"9000259862655"},{"@type":"NRID","@value":"9000238279648"},{"@type":"NRID","@value":"9000391987903"},{"@type":"NRID","@value":"9000391980632"},{"@type":"NRID","@value":"9000016969938"},{"@type":"NRID","@value":"9000002742757"},{"@type":"NRID","@value":"9000364832446"},{"@type":"NRID","@value":"9000006636012"},{"@type":"NRID","@value":"9000020186500"},{"@type":"NRID","@value":"9000399595211"},{"@type":"NRID","@value":"9000000362244"},{"@type":"NRID","@value":"9000018561993"},{"@type":"NRID","@value":"9000411116144"},{"@type":"NRID","@value":"9000411585562"},{"@type":"NRID","@value":"9000398991888"},{"@type":"NRID","@value":"9000347046817"},{"@type":"NRID","@value":"9000411377337"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kurumizaka"}],"foaf:name":[{"@language":"en","@value":"Kurumizaka, Hitoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751152546816","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60188191"},{"@type":"NRID","@value":"1000060188191"},{"@type":"CINII_AUTHOR_ID","@value":"DA13634636"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA13634636#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA13634636"},{"@type":"NRID","@value":"9000003008266"},{"@type":"NRID","@value":"9000237870126"},{"@type":"NRID","@value":"9000242883170"},{"@type":"NRID","@value":"9000391959805"},{"@type":"NRID","@value":"9000364830442"},{"@type":"NRID","@value":"9000237868496"},{"@type":"NRID","@value":"9000345441720"},{"@type":"NRID","@value":"9000408426638"},{"@type":"NRID","@value":"9000347048379"},{"@type":"NRID","@value":"9000347361786"},{"@type":"NRID","@value":"9000311069939"},{"@type":"NRID","@value":"9000403976150"},{"@type":"NRID","@value":"9000007409132"},{"@type":"NRID","@value":"9000364815688"},{"@type":"NRID","@value":"9000364831984"},{"@type":"NRID","@value":"9000005057774"},{"@type":"NRID","@value":"9000024686120"},{"@type":"NRID","@value":"9000347049193"},{"@type":"NRID","@value":"9000255959890"},{"@type":"NRID","@value":"9000010430868"},{"@type":"NRID","@value":"9000317127701"},{"@type":"NRID","@value":"9000024268876"},{"@type":"NRID","@value":"9000250183047"},{"@type":"NRID","@value":"9000402395289"},{"@type":"NRID","@value":"9000319553366"},{"@type":"NRID","@value":"9000240102514"},{"@type":"NRID","@value":"9000009097361"},{"@type":"NRID","@value":"9000398647307"},{"@type":"NRID","@value":"9000018894577"},{"@type":"NRID","@value":"9000024759944"},{"@type":"NRID","@value":"9000287286177"},{"@type":"NRID","@value":"9000391980260"},{"@type":"NRID","@value":"9000364830783"},{"@type":"NRID","@value":"9000364830558"},{"@type":"NRID","@value":"9000005048733"},{"@type":"NRID","@value":"9000398647278"},{"@type":"NRID","@value":"9000391982439"},{"@type":"NRID","@value":"9000391983855"},{"@type":"NRID","@value":"9000356567789"},{"@type":"NRID","@value":"9000364823663"},{"@type":"NRID","@value":"9000364825249"},{"@type":"NRID","@value":"9000347049091"},{"@type":"NRID","@value":"9000364828383"},{"@type":"NRID","@value":"9000388538398"},{"@type":"NRID","@value":"9000391979275"},{"@type":"NRID","@value":"9000255959885"},{"@type":"NRID","@value":"9000364829528"},{"@type":"NRID","@value":"9000347361583"},{"@type":"NRID","@value":"9000009353218"},{"@type":"NRID","@value":"9000242104116"},{"@type":"NRID","@value":"9000364829435"},{"@type":"NRID","@value":"9000359903827"},{"@type":"NRID","@value":"9000256198158"},{"@type":"NRID","@value":"9000365497585"},{"@type":"NRID","@value":"9000347667775"},{"@type":"NRID","@value":"9000238936602"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0080503"}],"foaf:name":[{"@language":"en","@value":"Takeda, Shunichi"},{"@language":"ja","@value":"武田, 俊一"}]},{"@id":"https://cir.nii.ac.jp/crid/1070282810694849543","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000024268840"}],"foaf:name":[{"@language":"en","@value":"Yamamoto, Kimiyo N"},{"@language":"ja","@value":"山本, 君代"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326219190272","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30281728"},{"@type":"NRID","@value":"1000030281728"},{"@type":"ORCID","@value":"0000-0002-4926-3675"},{"@type":"NRID","@value":"9000023591807"},{"@type":"NRID","@value":"9000253408687"},{"@type":"NRID","@value":"9000000569741"},{"@type":"NRID","@value":"9000018774843"},{"@type":"NRID","@value":"9000345441719"},{"@type":"NRID","@value":"9000391979172"},{"@type":"NRID","@value":"9000017396432"},{"@type":"NRID","@value":"9000359946997"},{"@type":"NRID","@value":"9000347050219"},{"@type":"NRID","@value":"9000391981986"},{"@type":"NRID","@value":"9000283494754"},{"@type":"NRID","@value":"9000024268866"},{"@type":"NRID","@value":"9000020591404"},{"@type":"NRID","@value":"9000257947354"},{"@type":"NRID","@value":"9000399595274"},{"@type":"NRID","@value":"9000409839728"},{"@type":"NRID","@value":"9000347091359"},{"@type":"NRID","@value":"9000403050373"},{"@type":"NRID","@value":"9000239867942"},{"@type":"NRID","@value":"9000237871266"},{"@type":"NRID","@value":"9000345442101"},{"@type":"NRID","@value":"9000280547318"},{"@type":"NRID","@value":"9000364831983"},{"@type":"NRID","@value":"9000022011444"},{"@type":"NRID","@value":"9000238936701"},{"@type":"NRID","@value":"9000397707637"},{"@type":"NRID","@value":"9000387916795"},{"@type":"NRID","@value":"9000375921818"},{"@type":"NRID","@value":"9000347093238"},{"@type":"NRID","@value":"9000403168966"},{"@type":"NRID","@value":"9000397846544"},{"@type":"NRID","@value":"9000391984791"},{"@type":"NRID","@value":"9000001211772"},{"@type":"NRID","@value":"9000331445929"},{"@type":"NRID","@value":"9000259862656"},{"@type":"NRID","@value":"9000327440307"},{"@type":"NRID","@value":"9000253613380"},{"@type":"NRID","@value":"9000391980635"},{"@type":"NRID","@value":"9000258044716"},{"@type":"NRID","@value":"9000002127606"},{"@type":"NRID","@value":"9000252813110"},{"@type":"NRID","@value":"9000412550954"},{"@type":"NRID","@value":"9000391985559"},{"@type":"NRID","@value":"9000015347750"},{"@type":"NRID","@value":"9000006862151"},{"@type":"NRID","@value":"9000345442343"},{"@type":"NRID","@value":"9000391987857"},{"@type":"NRID","@value":"9000327440308"},{"@type":"NRID","@value":"9000391980620"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0062989"}],"foaf:name":[{"@language":"en","@value":"Takata, Minoru"},{"@language":"ja","@value":"髙田, 穣"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1890020692656945671","@type":"Researcher","foaf:name":[{"@value":"Hirota, K"}]},{"@id":"https://cir.nii.ac.jp/crid/1890020692656945668","@type":"Researcher","foaf:name":[{"@value":"University of Zurich"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00278424"},{"@type":"NCID","@value":"AA10808769"}],"prism:publicationName":[{"@language":"en","@value":"Proceedings of the National Academy of Sciences (PNAS)"}],"dc:publisher":[{"@value":"National Academy of Sciences"}],"prism:publicationDate":"2011-04-19","prism:volume":"108","prism:number":"16","prism:startingPage":"6492","prism:endingPage":"6496"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["©2011 by the National Academy of Sciences","This is not the published version. Please cite only the published version.","この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。"],"url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1018487108"},{"@id":"http://hdl.handle.net/2433/141829"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=SLX4","dc:title":"SLX4"},{"@id":"https://cir.nii.ac.jp/all?q=Fanconi%20anemia","dc:title":"Fanconi anemia"},{"@id":"https://cir.nii.ac.jp/all?q=interstrand%20cross-links","dc:title":"interstrand cross-links"},{"@id":"https://cir.nii.ac.jp/all?q=mitomycin%20C","dc:title":"mitomycin C"},{"@id":"https://cir.nii.ac.jp/all?q=cisplatin","dc:title":"cisplatin"},{"@id":"https://cir.nii.ac.jp/all?q=endonuclease","dc:title":"endonuclease"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"SLX4"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Fanconi anemia"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"interstrand cross-links"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"mitomycin C"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"cisplatin"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"endonuclease"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782028012288","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20114001"},{"@type":"JGN","@value":"JP20114001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20114001/"}],"notation":[{"@language":"ja","@value":"遺伝情報収納・発現・継承の時空間場"},{"@language":"en","@value":"The physicochemical field for genetic activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782029477376","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20241012"},{"@type":"JGN","@value":"JP20241012"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20241012/"}],"notation":[{"@language":"ja","@value":"ニワトリ細胞株DT40の遺伝子破壊による、DNA損傷への応答機構の網羅的解析"},{"@language":"en","@value":"Analysis of DNA damage response using gene-disrupted DT40 clones."}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782063262336","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21114509"},{"@type":"JGN","@value":"JP21114509"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21114509/"}],"notation":[{"@language":"ja","@value":"ノンコーディングRNA転写に共役する新規クロマチン制御機構の解明"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782072925824","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21390094"},{"@type":"JGN","@value":"JP21390094"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390094/"}],"notation":[{"@language":"ja","@value":"複製フォーク停止に応答するチェックポイントキナーゼによるユビキチン"},{"@language":"en","@value":"Regulation of the ubiquitin system by checkpoint kinases in response to stalled replication forks"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782112441600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22390126"},{"@type":"JGN","@value":"JP22390126"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390126/"}],"notation":[{"@language":"ja","@value":"遺伝子破壊メダカとニワトリBリンパ球細胞を使用した化学物質の複合影響評価"},{"@language":"en","@value":"Assessment of combined effect of chemicals with using mutant DT40s and gene knock out Medaka."}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782141411328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23114010"},{"@type":"JGN","@value":"JP23114010"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23114010/"},{"@type":"KAKEN","@value":"23114010"}],"notation":[{"@language":"ja","@value":"複製フォークの安定化機構とその破綻による病態の解析"},{"@language":"en","@value":"Analysis of disorders defective in the mechanisms for fork stabilization"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257029325824","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20651014"},{"@type":"JGN","@value":"JP20651014"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20651014/"}],"notation":[{"@language":"ja","@value":"ファンコニ貧血経路の真のターゲットは内因性ホルマリンによる蛋白質ゲノム架橋か?"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257084524032","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22310119"},{"@type":"JGN","@value":"JP22310119"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22310119/"}],"notation":[{"@language":"ja","@value":"新規相同組換え因子の探索と組換え反応機構の解析"},{"@language":"en","@value":"Identification and biochemical analyses of novel factors that are involved in homologous recombination reaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257107757056","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22687001"},{"@type":"JGN","@value":"JP22687001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22687001/"}],"notation":[{"@language":"ja","@value":"プロテオミクスと遺伝学の融合によるクロマチンーDNA修復のクロストークの解明"},{"@language":"en","@value":"Analysis of DNA repair pathway by the combination of proteomics andgenetic approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257149694848","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23651046"},{"@type":"JGN","@value":"JP23651046"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23651046/"}],"notation":[{"@language":"ja","@value":"細胞周期特異的デグロンによる蛋白質発現制御と機能解析への応用"},{"@language":"en","@value":"Regulation of protein expression using a cell cyclce-specific degron and its application to functional analysis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202113363712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions."},{"@value":"Simultaneous disruption of two DNA polymerases, Poleta and Polzeta, in Avian DT40 cells unmasks the role of Poleta in cellular response to various DNA lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1050001338207742336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282677930378112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress"},{"@value":"<scp>FANCD</scp>2 protects genome stability by recruiting <scp>RNA</scp> processing enzymes to resolve R‐loops during mild replication stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810743798656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair."}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810768198272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810825979136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end"},{"@value":"FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285808328576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1050571395554782592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760707942912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237559980416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Defective FANCI Binding by a Fanconi Anemia-Related FANCD2 Mutant"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237614695040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237935549824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Defects in homologous recombination repair behind the human diseases: FA and HBOC"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144630501376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145607092736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146278489984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Mus81-Associated Endonuclease Cleaves Holliday Junctions In Vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389798979712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390762411008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proofreading exonuclease activity of replicative polymerase epsilon promotes cellular tolerance to arabinosides in CTF18-dependent and -independent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430660078976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430665972736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<scp>RAD18</scp>‐ and <scp>BRCA1</scp>‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025431138252544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691059686784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of the FA pathway mediated by phosphorylation and ubiquitination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692582123776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693687823360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Third Report on Chicken Genes and Chromosomes 2015"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707075970176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707352489472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712530028288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA-Associated Cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619232524800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619965191040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621511158400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864773029504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167306332160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167743974144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of the Fanconi anemia pathway by a SUMO-like delivery network"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567188082123264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095137253632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095762013184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Slx1-Slx4 Are Subunits of a Structure-specific Endonuclease That Maintains Ribosomal DNA in Fission Yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096418504192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230628363008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588379381176704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641009961472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mcm8 and Mcm9 Form a Complex that Functions in Homologous Recombination Repair Induced by DNA Interstrand Crosslinks"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656982544384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658886979456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659552241152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human FAN1 promotes strand incision in 5′-flapped DNA complexed with RPA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569197965568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Positional Cloning of a Novel Fanconi Anemia Gene, FANCD2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571035129728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fanconi Anemia (Cross)linked to DNA Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571261196032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854339356928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"FANCD2 counteracts O6-methylguanine-induced mismatch repair-dependent apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854367851008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"PrimPol-mediated repriming elicits gap-filling by template switching and promotes cellular tolerance to cidofovir"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045089560960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046423837184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519227685120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520313557120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994224993792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995525411840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468462609536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Fanconi anemia pathway and ICL repair: implications for cancer therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468553711488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470747070080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ubiquitin-binding domains and their role in the DNA damage response"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471368241792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471411094272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945328694912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945887044480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caenorhabditis elegans HIM-18/SLX-4 Interacts with SLX-1 and XPF-1 and Maintains Genomic Integrity in the Germline by Processing Recombination Intermediates"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418607718784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A requirement of FancL and FancD2 monoubiquitination in DNA repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419895241600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How the Fanconi Anemia Pathway Guards the Genome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420248632576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420642738944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421272769152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893426099328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Critical Role for the Ubiquitin-Conjugating Enzyme Ubc13 in Initiating Homologous Recombination"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894039297024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RNA Interference Inhibition of Mus81 Reduces Mitotic Recombination in Human Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895562907008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Growth Retardation, Early Death, and DNA Repair Defects in Mice Deficient for the Nucleotide Excision Repair Enzyme XPF"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896080418048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368614191232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generating Crossovers by Resolution of Nicked Holliday Junctions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843717022720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Slx1—Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1—Top3"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843720182016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319482658944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification and Characterization of the Human Mus81-Eme1 Endonuclease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320115680512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269334206080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269626568192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Biology of Fanconi Anemia: Implications for Diagnosis and Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269730449152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Drosophila MUS312 Interacts with the Nucleotide Excision Repair Endonuclease MEI-9 to Generate Meiotic Crossovers"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270392037632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Breaking Up Just Got Easier to Do"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271270972288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations of the SLX4 gene in Fanconi anemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651331972224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates"},{"@value":"Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates."}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01221:0000105203"},{"@type":"CROSSREF","@value":"10.1073/pnas.1018487108"},{"@type":"CIA","@value":"120003072120"},{"@type":"KAKEN","@value":"PRODUCT-11912712"},{"@type":"KAKEN","@value":"PRODUCT-11947701"},{"@type":"KAKEN","@value":"PRODUCT-11947758"},{"@type":"KAKEN","@value":"PRODUCT-12518615"},{"@type":"KAKEN","@value":"PRODUCT-12711731"},{"@type":"KAKEN","@value":"PRODUCT-12711784"},{"@type":"KAKEN","@value":"PRODUCT-13353940"},{"@type":"KAKEN","@value":"PRODUCT-13772476"},{"@type":"KAKEN","@value":"PRODUCT-12359528"},{"@type":"KAKEN","@value":"PRODUCT-13268928"},{"@type":"KAKEN","@value":"PRODUCT-13631994"},{"@type":"KAKEN","@value":"PRODUCT-13631992"},{"@type":"KAKEN","@value":"PRODUCT-14227614"},{"@type":"KAKEN","@value":"PRODUCT-14227631"},{"@type":"OPENAIRE","@value":"doi_dedup___::6149f65f5ad470728d1737e5f93423d5"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0188320_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0114752_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0185141_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0192421_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1530/erc-16-0221_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2014.04.005_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1667/rr14117.1_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2024.103668_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1007/s42764-024-00124-w_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2024.103773_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1111/gtc.13155_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1371/journal.pgen.1011341_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1038/emboj.2012.197_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1093/nar/gks053_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1093/nar/gkw876_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0105724_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1093/nar/gkad999_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1080/15384101.2016.1191711_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2018.06.003_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1101/gad.17020911_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2021.109879_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2023.103503_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1093/nar/gkae263_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1093/jb/mvv043_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1093/nar/gkt467_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1111/febs.14700_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.chemosphere.2016.08.092_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.molcel.2012.05.047_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1159/000430927_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1007/s11033-024-09682-4_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.dnarep.2024.103787_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.molcel.2012.05.026_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"},{"@type":"CROSSREF","@value":"10.1016/j.mrfmmm.2017.05.003_references_DOI_X7u7akIg6zWSwEVuDzVvpOpSwWs"}]}