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Econazole, one of azole antifungals, is proven to exhibit an inhibitory action on Mycobaterium tuberculosis and its multidrug-resistant strains under in vitro and ex vivo conditions. However, econazole has been used as a pharmacological tool for inhibiting capacitative Ca2+ influx and exerts multiple effects on cellular Ca2+ circumstance. Therefore, to suggest the toxic effect of econazole at therapeutic concentrations, we have tested on the effect on membrane Ca2+ transport in rat thymocytes by using a flow cytometer with Fluo-3, an indicator of intracellular Ca2+. Econazole at concentrations of 1-3 μM increased membrane Ca2+ permeability and inhibited capacitative Ca2+ influx without affecting passive Ca2+ influx, Ca2+ release from intracellular Ca2+ store sites, and membrane Ca2+ pump. Econazole at 0.3 μM, a therapeutic concentration against tuberculosis caused by multidrug-resistant and latent M. tuberculosis, did not affect membrane Ca2+ transport. It may be suggested that econazole at therapeutic concentrations exerts no side effect related to Ca2+.
収録刊行物
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- 徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima
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徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima 23 (1), 1-6, 2009-03-25
徳島大学総合科学部
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詳細情報 詳細情報について
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- CRID
- 1050282812440407552
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- NII論文ID
- 110008699543
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- NII書誌ID
- AN10065859
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- ISSN
- 09146385
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- NDL書誌ID
- 10783951
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
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