Erlotinib でinduction therapy を行ったIIIA期非小細胞肺癌の1手術例

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  • ショウレイ ホウコク(ダイ8カイ ワカテ ショウレイショウ ジュショウ ロンブン) Erlotinib デ induction therapy オ オコナッタ Ⅲ Aキ ヒショウサイボウ ハイガン ノ 1 シュジュツレイ
  • A surgical case of stage IIIA non-small cell lung cancer with EGFR-TKI as induction therapy
  • Erlotinib デ induction therapy オ オコナッタ IIIAキ ヒショウサイボウ ハイガン ノ 1シュジュツレイ

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[Background ]Erlotinib, epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI), is effective for advanced and metastatic non-small cell lung cancer(NSCLC)with EGFR mutation. However, the report of Erlotinib as induction therapy is rare. We report a surgical case of NSCLC with Erlotinib as induction therapy. [Case ]A41-years-old man, diagnosed left lung adenocarcinoma with EGFR mutation(exon19deletion), was referred to our hospital. CT showed that the tumor was 35mm in S8 of the left lung and #7 lymphnode was swelling markedly(cT2aN2M0 stage ⅢA). He took Erlotinib(150mg/day)for12weeks at first because of EGFR mutation positive. The evaluation of Erlotinib was partial response in RESIST. He could take radical operation as lower lobe and lingual segment resection, because CT showed bulky #7got smaller significantly. There was no postoperative complication. The pathological finding was adenocarcinoma(papillary& acinartype), PL0, v(+), ly(+), br(-), pa(-), pv(-), Ef :1b,(ypT1aN2M0stage ⅢA). He has taken adjuvant therapy(Erlotinib150mg/day)for28weeks. There is no recurrence six months after operation. [Conclusion ]It is possible that Erlotinib as induction-therapy is very effective in patients with EGFR mutation like this case ; however there is no evidence of EGFR-TKI as induction therapy. It is necessary to validate the effectiveness of Erlotinib as induction therapy.

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