書誌事項
- タイトル別名
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- ジュウショウ カンジャ ニ オケル キン イシュク ト ニョウチュウ タイチン ノウド ソクテイ ノ イギ : ダイ45カイ トクシマ イガッカイショウ ジュショウ ロンブン
- Urinary titin reflects muscle atrophy in critical ill patients
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抄録
Skeletal muscle atrophy is a serious problem in critically ill patients. After intensive care unit (ICU)admission, muscle atrophy starts within 3 days and progressively worsens thereafter. We have previously reported that upper and lower limb muscle mass of critically ill patients decreased by 13%‐21% within 7 days of admission. Muscle atrophy in the ICU is associated with long-term functional impairment and weakness in ICU survivors. Although monitoring of muscle mass is important, there have been no reliable biomarkers associated with muscle atrophy in critically ill patients. In this study, we have focused on urinary titin, which is the biggest giant sarcomere protein and functions as a spring for muscle extension and viscoelasticity. We have clarified that urinary titin level reflected muscle breakdown correlated with limb muscle atrophy in non-surgical critically ill patients. The cumulative urinary titin level associated with the incidence of ICU-AW and ICU mortality. Our study indicates urinary titin can be the noble biomarker to evaluate the catabolism and muscle atrophy in critically ill patients.
収録刊行物
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- 四国医学雑誌
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四国医学雑誌 76 (5-6), 267-272, 2020-12-25
徳島医学会
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詳細情報 詳細情報について
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- CRID
- 1050287363395004928
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- NII論文ID
- 120006979184
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- NII書誌ID
- AN00102041
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- ISSN
- 00373699
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- NDL書誌ID
- 031365319
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- NDL
- CiNii Articles