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Multidrug-resistant nephrotic syndrome (MRNS) is associated with a poor kidney prognosis. Several retrospective studies have identified rituximab as an effective treatment for MRNS; however, prospective studies are required to assess its efficacy and safety. Methods: We conducted a multicenter, non-blinded, single-arm trial to investigate the efficacy and safety of rituximab in patients with childhood-onset MRNS who were resistant to cyclosporine and more than three courses of steroid pulse therapy. The enrolled patients received four 375 mg/m² doses of rituximab in combination with baseline cyclosporine and steroid pulse therapy. The primary endpoint was a > 50% reduction in the urinary protein/creatinine ratio from baseline on day 169. Complete and partial remissions were also evaluated. Results: Six patients with childhood-onset MRNS were enrolled. All patients were negative for pathogenic variants of podocyte-related genes. On day 169, five patients (83.3%) showed a > 50% reduction in the urinary protein/creatinine ratio, two patients showed partial remission, and two patients showed complete remission. No deaths occurred and severe adverse events occurred in two patients (infection in one patient and acute kidney injury in one patient). Three patients needed treatment for moderate-to-severe infection. Conclusions: The study treatment effectively reduced the urinary protein/creatinine ratio in patients with childhood-onset MRNS. The adverse events in this study were within the expected range; however, attention should be paid to the occurrence of infections."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801211591040","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70362796"},{"@type":"NRID","@value":"1000070362796"},{"@type":"NRID","@value":"9000020379329"},{"@type":"NRID","@value":"9000411276162"},{"@type":"NRID","@value":"9000409296451"},{"@type":"NRID","@value":"9000410022884"},{"@type":"NRID","@value":"9000409885616"},{"@type":"NRID","@value":"9000398293095"},{"@type":"NRID","@value":"9000398991546"},{"@type":"NRID","@value":"9000409848599"},{"@type":"NRID","@value":"9000238822429"},{"@type":"NRID","@value":"9000391408121"},{"@type":"NRID","@value":"9000409864224"},{"@type":"NRID","@value":"9000239609145"},{"@type":"NRID","@value":"9000412107558"},{"@type":"NRID","@value":"9000020336042"},{"@type":"NRID","@value":"9000408805742"},{"@type":"NRID","@value":"9000381958844"},{"@type":"NRID","@value":"9000411517019"},{"@type":"NRID","@value":"9000403323803"},{"@type":"NRID","@value":"9000345297382"},{"@type":"NRID","@value":"9000409998022"},{"@type":"NRID","@value":"9000408790204"},{"@type":"NRID","@value":"9000016425370"},{"@type":"NRID","@value":"9000412200595"},{"@type":"NRID","@value":"9000412299772"},{"@type":"NRID","@value":"9000409175915"},{"@type":"NRID","@value":"9000402502128"},{"@type":"NRID","@value":"9000414481990"},{"@type":"NRID","@value":"9000411489303"},{"@type":"NRID","@value":"9000409175904"},{"@type":"NRID","@value":"9000404481319"},{"@type":"NRID","@value":"9000403105296"},{"@type":"NRID","@value":"9000409620359"},{"@type":"NRID","@value":"9000415325727"},{"@type":"NRID","@value":"9000005923845"},{"@type":"NRID","@value":"9000413495226"},{"@type":"NRID","@value":"9000413945444"},{"@type":"NRID","@value":"9000410485189"},{"@type":"NRID","@value":"9000410618535"},{"@type":"NRID","@value":"9000404131452"},{"@type":"NRID","@value":"9000378105375"},{"@type":"NRID","@value":"9000378104860"},{"@type":"NRID","@value":"9000410194249"},{"@type":"NRID","@value":"9000404644827"},{"@type":"NRID","@value":"9000413938372"},{"@type":"NRID","@value":"9000397954973"},{"@type":"NRID","@value":"9000239599731"},{"@type":"NRID","@value":"9000312731426"},{"@type":"NRID","@value":"9000021994556"},{"@type":"NRID","@value":"9000409179761"},{"@type":"NRID","@value":"9000399532546"},{"@type":"NRID","@value":"9000410507290"},{"@type":"NRID","@value":"9000404821348"},{"@type":"NRID","@value":"9000399545231"},{"@type":"NRID","@value":"9000415325700"},{"@type":"NRID","@value":"9000411503785"},{"@type":"NRID","@value":"9000410959867"},{"@type":"NRID","@value":"9000413473693"},{"@type":"NRID","@value":"9000402138674"},{"@type":"NRID","@value":"9000409175924"},{"@type":"NRID","@value":"9000411761319"},{"@type":"NRID","@value":"9000409624126"},{"@type":"NRID","@value":"9000413354700"},{"@type":"NRID","@value":"9000409206295"},{"@type":"NRID","@value":"9000401954564"},{"@type":"NRID","@value":"9000403029908"},{"@type":"NRID","@value":"9000342448508"},{"@type":"NRID","@value":"9000239592357"},{"@type":"NRID","@value":"9000414941351"},{"@type":"NRID","@value":"9000413372916"},{"@type":"NRID","@value":"9000411489375"},{"@type":"NRID","@value":"9000411542481"},{"@type":"NRID","@value":"9000397857315"},{"@type":"NRID","@value":"9000404821727"},{"@type":"NRID","@value":"9000402502234"},{"@type":"NRID","@value":"9000410194259"},{"@type":"NRID","@value":"9000402942254"},{"@type":"NRID","@value":"9000403324105"},{"@type":"NRID","@value":"9000345195351"},{"@type":"NRID","@value":"9000404343519"},{"@type":"NRID","@value":"9000409599853"},{"@type":"NRID","@value":"9000406031273"},{"@type":"NRID","@value":"9000415325563"},{"@type":"NRID","@value":"9000413947030"},{"@type":"NRID","@value":"9000021485426"},{"@type":"NRID","@value":"9000410618437"},{"@type":"NRID","@value":"9000380123310"},{"@type":"NRID","@value":"9000409848680"},{"@type":"NRID","@value":"9000239608252"},{"@type":"NRID","@value":"9000021994613"},{"@type":"NRID","@value":"9000410916737"},{"@type":"NRID","@value":"9000410507591"},{"@type":"NRID","@value":"9000408632278"},{"@type":"NRID","@value":"9000408475308"},{"@type":"NRID","@value":"9000402264838"},{"@type":"NRID","@value":"9000405929850"},{"@type":"NRID","@value":"9000239583177"},{"@type":"NRID","@value":"9000414241872"},{"@type":"NRID","@value":"9000402139137"},{"@type":"NRID","@value":"9000390891439"},{"@type":"NRID","@value":"9000408923296"},{"@type":"NRID","@value":"9000410347891"},{"@type":"NRID","@value":"9000238476122"},{"@type":"NRID","@value":"9000345297499"},{"@type":"NRID","@value":"9000322731303"},{"@type":"NRID","@value":"9000239599723"},{"@type":"NRID","@value":"9000414482056"},{"@type":"NRID","@value":"9000412400483"},{"@type":"NRID","@value":"9000414549841"},{"@type":"NRID","@value":"9000402139153"},{"@type":"NRID","@value":"9000399804291"},{"@type":"NRID","@value":"9000409848711"},{"@type":"NRID","@value":"9000405657174"},{"@type":"NRID","@value":"9000239599716"},{"@type":"NRID","@value":"90004122005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