In vitro hair follicle growth model for drug testing

DOI 機関リポジトリ 機関リポジトリ (HANDLE) PDF Web Site ほか1件をすべて表示 一部だけ表示 被引用文献4件 参考文献43件 オープンアクセス

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公開日
2023-03-24
資源種別
journal article
権利情報
  • Creative Commons Attribution 4.0 International
DOI
  • 10.1038/s41598-023-31842-y
公開者
Nature Portfolio

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説明

In vitro models of human hair follicle-like tissue could be fundamental tools to better understand hair follicle morphogenesis and hair drug screening. During prenatal development and postnatal cyclic hair regeneration, hair follicle morphogenesis is triggered by reciprocal interactions and the organization of the epithelial and mesenchymal cell populations. Given this mechanism, we developed an approach to induce hair peg-like sprouting in organoid cultures composed of epithelial and mesenchymal cells. Human fetal/adult epithelial and mesenchymal cells were cultured in a medium supplemented with a low concentration of either Matrigel or collagen I. These extracellular matrices significantly enhanced the self-organization capabilities of the epithelial and mesenchymal cells, resulting in spherical aggregation and subsequent hair peg-like sprouting. The length of the hair peg sprouting and associated gene expression significantly increased in the presence of a well-known hair drug, minoxidil. This approach may be beneficial for testing hair growth-promoting drug candidates.

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