{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050301994524673536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/290021"}},{"identifier":{"@type":"DOI","@value":"10.1016/j.resinv.2024.08.014"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2212534524001357?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2212534524001357?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2025314139"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Lung imaging in COPD and asthma."}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"Chronic obstructive pulmonary disease (COPD) and asthma are common lung diseases with heterogeneous clinical presentations. Lung imaging allows evaluations of underlying pathophysiological changes and provides additional personalized approaches for disease management. This narrative review provides an overview of recent advances in chest imaging analysis using various modalities, such as computed tomography (CT), dynamic chest radiography, and magnetic resonance imaging (MRI). Visual CT assessment localizes emphysema subtypes and mucus plugging in the airways. Dedicated software quantifies the severity and spatial distribution of emphysema and the airway tree structure, including the central airway wall thickness, branch count and fractal dimension of the tree, and airway-to-lung size ratio. Nonrigid registration of inspiratory and expiratory CT scans quantifies small airway dysfunction, local volume changes and shape deformations in specific regions. Lung ventilation and diaphragm movement are also evaluated on dynamic chest radiography. Functional MRI detects regional oxygen transfer across the alveolus using inhaled oxygen and ventilation defects and gas diffusion into the alveolar–capillary barrier tissue and red blood cells using inhaled hyperpolarized ¹²⁹Xe gas. These methods have the potential to determine local functional properties in the lungs that cannot be detected by lung function tests in patients with COPD and asthma. Further studies are needed to apply these technologies in clinical practice, particularly for early disease detection and tailor-made interventions, such as the efficient selection of patients likely to respond to biologics. Moreover, research should focus on the extension of healthy life expectancy in patients at higher risk and with established diseases."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801207807616","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30805817"},{"@type":"NRID","@value":"1000030805817"},{"@type":"ORCID","@value":"0000-0002-7481-0212"},{"@type":"NRID","@value":"9000023169792"},{"@type":"NRID","@value":"9000406379980"},{"@type":"NRID","@value":"9000408905607"},{"@type":"NRID","@value":"9000412206703"},{"@type":"NRID","@value":"9000410484807"},{"@type":"NRID","@value":"9000402608890"},{"@type":"NRID","@value":"9000406379965"},{"@type":"NRID","@value":"9000412234883"},{"@type":"NRID","@value":"9000399010231"},{"@type":"NRID","@value":"9000006227078"},{"@type":"NRID","@value":"9000412112673"},{"@type":"NRID","@value":"9000023333862"},{"@type":"NRID","@value":"9000024165071"},{"@type":"NRID","@value":"9000411585490"},{"@type":"NRID","@value":"9000322108863"},{"@type":"NRID","@value":"9000410618116"},{"@type":"NRID","@value":"9000411771603"},{"@type":"NRID","@value":"9000410918702"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000020623"}],"foaf:name":[{"@language":"en","@value":"Tanabe, Naoya"},{"@language":"ja","@value":"田辺, 直也"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673544","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Nakagawa, Hiroaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673537","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sakao, Seiichiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673541","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ohno, Yoshiharu"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673540","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Shimizu, Kaoruko"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673536","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Nakamura, Hidetoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673543","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hanaoka, Masayuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673542","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Nakano, Yasutaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1070301994524673539","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hirai, Toyohiro"},{"@language":"ja","@value":"平井, 豊博"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"22125345"}],"prism:publicationName":[{"@language":"en","@value":"Respiratory investigation"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2024-11","prism:volume":"62","prism:number":"6","prism:startingPage":"995","prism:endingPage":"1005"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© 2024 The Authors. Published by Elsevier B.V. on behalf of The Japanese Respiratory Society. This is an open access article under the CC BY license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2212534524001357?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2212534524001357?httpAccept=text/plain"},{"@id":"https://search.jamas.or.jp/link/ui/2025314139"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Quantitative%20imaging","dc:title":"Quantitative imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Computed%20tomography","dc:title":"Computed tomography"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20function","dc:title":"Lung function"},{"@id":"https://cir.nii.ac.jp/all?q=Chronic%20obstructive%20pulmonary%20disease","dc:title":"Chronic obstructive pulmonary disease"},{"@id":"https://cir.nii.ac.jp/all?q=Asthma","dc:title":"Asthma"},{"@id":"https://cir.nii.ac.jp/all?q=Contents","dc:title":"Contents"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Quantitative imaging"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Computed tomography"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Lung function"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Chronic obstructive pulmonary disease"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Asthma"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Contents"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040854882519831168","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K08233"},{"@type":"JGN","@value":"JP22K08233"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08233/"}],"notation":[{"@language":"ja","@value":"免疫学的恒常性の破綻と肺気腫フェノタイプの形成機序の解明"},{"@language":"en","@value":"Disruption of immune homeostasis in the pathogenesis of emphysema subtypes"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202796527488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"An index of the fractal characteristic of an airway tree is associated with airflow limitations and future body mass index reduction in COPD patients."}]},{"@id":"https://cir.nii.ac.jp/crid/1050285700403624448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Quantitative measurement of airway dimensions using ultra-high resolution computed tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1050306506458531456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of airway remodelling assessed by computed tomography in asthma and COPD"},{"@value":"Comparison of airway 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