{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050303564713727872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"URI","@value":"https://hiroshima.repo.nii.ac.jp/records/2006501"}},{"identifier":{"@type":"DOI","@value":"10.1186/s12871-018-0537-1"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1186/s12871-018-0537-1.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1186/s12871-018-0537-1/fulltext.html"}},{"identifier":{"@type":"PMID","@value":"29921225"}},{"identifier":{"@type":"HANDLE","@value":"2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/277890"}},{"identifier":{"@type":"NAID","@value":"120006557548"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effects of acute ethanol intoxication in an ovine peritonitis model"}],"dc:language":"en","description":[{"notation":[{"@value":"Acute ethanol intoxication has been shown to have contrasting effects on outcomes in sepsis. The aim of this study was to explore the effects of acute ethanol intoxication on hemodynamics, renal function, brain perfusion and lactate/pyruvate in an ovine sepsis model.Anesthetized, mechanically ventilated female sheep were randomized to an ethanol group (n = 7), which received 1 g/kg ethanol diluted in intravenous (i.v.) saline infusion or a control group (n = 7), which received the same volume of i.v. saline. Both groups received the treatment for a period of 2 h prior to induction of sepsis by intraperitoneal injection of feces. Other treatment included fluid resuscitation but no vasopressors or antibiotics. Global hemodynamics, renal blood flow, brain cortex laser Doppler flowmetry and microdialysis analyses were recorded hourly.In the ethanol group, blood ethanol concentrations were 137 ± 29 mg/dL at the time of feces injection and decreased to become undetectable by 12 h. Arterial hypotension occurred earlier in the ethanol than in the control group (8 [7-12] vs. 14 [11-20] hours, p = 0.03). Lactate levels increased to 2 mmol/L earlier in the ethanol group. Renal dysfunction (9 [6-13] vs. 13 [12-15] hours, p = 0.05) and oliguria (urine output 0.5 mL/kg/h; 10 [7-12] vs. 13 [12, 13] hours, p = 0.01) developed earlier in the ethanol than in the control group. Brain blood flow and lactate/pyruvate were unaffected. There was no significant difference in survival time.Acute ethanol intoxication in this model of peritonitis resulted in earlier development of shock and renal dysfunction but did not alter brain perfusion and metabolism or short-term survival."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751143108224","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70568188"},{"@type":"NRID","@value":"1000070568188"},{"@type":"NRID","@value":"9000410628401"},{"@type":"NRID","@value":"9000014620117"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/khosok"}],"foaf:name":[{"@language":"en","@value":"Hosokawa, Koji"}]},{"@id":"https://cir.nii.ac.jp/crid/1070303564713727872","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000399804893"}],"foaf:name":[{"@language":"en","@value":"Su, Fuhong"}]},{"@id":"https://cir.nii.ac.jp/crid/1070303564713727874","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000399804894"}],"foaf:name":[{"@language":"en","@value":"Silvio Taccone, Fabio"}]},{"@id":"https://cir.nii.ac.jp/crid/1070303564713727875","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000399804895"}],"foaf:name":[{"@language":"en","@value":"Creteur, Jacques"}]},{"@id":"https://cir.nii.ac.jp/crid/1070303564713727873","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000399804896"}],"foaf:name":[{"@language":"en","@value":"Vincent, Jean-Louis"}]}],"publication":{"publicationIdentifier":[{"@type":"ISSN","@value":"14712253"},{"@type":"EISSN","@value":"14712253"}],"prism:publicationName":[{"@value":"BMC Anesthesiology"},{"@value":"BMC Anesthesiology"}],"dc:publisher":[{"@value":"Springer Nature"}],"prism:publicationDate":"2018-06-19","prism:volume":"18","prism:startingPage":"70"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."],"url":[{"@id":"https://hiroshima.repo.nii.ac.jp/records/2006501"},{"@id":"http://link.springer.com/content/pdf/10.1186/s12871-018-0537-1.pdf"},{"@id":"http://link.springer.com/article/10.1186/s12871-018-0537-1/fulltext.html"},{"@id":"http://ir.lib.hiroshima-u.ac.jp/00047066"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Ethanol%20intoxication","dc:title":"Ethanol intoxication"},{"@id":"https://cir.nii.ac.jp/all?q=Sepsis","dc:title":"Sepsis"},{"@id":"https://cir.nii.ac.jp/all?q=Septic%20shock","dc:title":"Septic shock"},{"@id":"https://cir.nii.ac.jp/all?q=Renal%20blood%20flow","dc:title":"Renal blood flow"},{"@id":"https://cir.nii.ac.jp/all?q=Brain%20perfusion","dc:title":"Brain perfusion"},{"@id":"https://cir.nii.ac.jp/all?q=Lactate/pyruvate","dc:title":"Lactate/pyruvate"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@value":"Ethanol intoxication"}]},{"subjectScheme":"Other","notation":[{"@value":"Sepsis"}]},{"subjectScheme":"Other","notation":[{"@value":"Septic shock"}]},{"subjectScheme":"Other","notation":[{"@value":"Renal blood flow"}]},{"subjectScheme":"Other","notation":[{"@value":"Brain perfusion"}]},{"subjectScheme":"Other","notation":[{"@value":"Lactate/pyruvate"}]},{"subjectScheme":"NDC","notation":[{"@value":"490"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782000979584","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K08888"},{"@type":"JGN","@value":"JP18K08888"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08888/"}],"notation":[{"@language":"ja","@value":"敗血症性脳症の発症メカニズム解明および新たな治療法確立"},{"@language":"en","@value":"New approach for treatment of septic encephalopathy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145429980800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients*"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618561021696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lactate Measurement After Cardiac Arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620609586816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093706348544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kinetics of ethanol metabolism in 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