書誌事項
- タイトル別名
-
- ダイ20カイ トクシマ イガッカイショウ ジュショウ ロンブン コウリンケツショウ ト シン ケッカン シッカン
- Hyperphosphatemia and cardiovascular disease
- コウリン ケッショウ ト シン ケッカン シッカン
この論文をさがす
抄録
Hyperphosphatemia has been known as a risk factor for cardiovascular disease particularly inchronic kidney disease patients. Hyperphosphatemia can be involved in the calcification of vascularsmooth muscle cells, resulting in M¨onkeberg medial calcific sclerosis which is a type of arteriosclerosis.However, it has not been clarified whether hyperphosphatemia can deteriorate endothelialfunction and can be a risk factor of atherosclerosis. Our recent study demonstrated that hyperphosphatemiaincreased oxidative stress and decreased nitric oxide production in endothelial cells.In addition, hyperphosphatemia attenuated endothelium-dependent vasodilation reaction. Theseobservations suggest that hyperphosphatemia may cause endothelial dysfunction, and be an importantfactor for progression of atherosclerosis as well as vascular calcification. Positive associationbetween hyperphosphatemia and cardiovascular disease may be explained by the dual harmfuleffects of phosphorus on the vessels.
収録刊行物
-
- 四国医学雑誌
-
四国医学雑誌 64 (3-4), 114-116, 2008-08-25
徳島医学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1050564287418501888
-
- NII論文ID
- 120006335075
-
- NII書誌ID
- AN00102041
-
- ISSN
- 00373699
-
- NDL書誌ID
- 9693650
-
- 本文言語コード
- ja
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- NDL
- CiNii Articles
- KAKEN