{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050570699974137088.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"URI","@value":"https://ousar.lib.okayama-u.ac.jp/60819"}},{"identifier":{"@type":"DOI","@value":"10.1007/s00774-020-01135-9"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s00774-020-01135-9.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s00774-020-01135-9/fulltext.html"}},{"identifier":{"@type":"PMID","@value":"33025107"}},{"identifier":{"@type":"NAID","@value":"120007141460"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2022000448"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading"}],"dc:language":"en","description":[{"type":"Other","notation":[{"@value":"Introduction</br>\nMechanical stimuli regulate Sclerostin (Scl), a negative regulator of bone formation, expression in osteocytes. However, the detailed Scl distribution in osteocytes in response to mechanical unloading remains unclear.</br>\nMaterials and methods</br>\nTwelve-week-old male rats were used. The sciatic and femoral nerves on the right side were excised as mechanical unloading treatment. A sham operation was performed on the left side. One week after neurotrauma, the bone density of the femora was evaluated by peripheral quantitative computed tomography, and immunofluorescence was performed in coronal sections of the femoral diaphysis. The mean fluorescence intensity and fluorescent profile of Scl from the marrow to the periosteal side were analyzed to estimate the Scl expression and determine to which side (marrow or periosteal) the Scl prefers to distribute in response to mechanical unloading. The most sensitive region indicated by the immunofluorescence results was further investigated by transmission electron microscopy (TEM) with immunogold staining to show the Scl expression changes in different subcellular structures.</br>\nResults</br>\nIn femur distal metaphysis, neurotrauma-induced mechanical unloading significantly decreased the bone density, made the distribution of Scl closer to the marrow on the anterior and medial side, and increased the Scl expression only on the lateral side. TEM findings showed that only the expression of Scl in canaliculi was increased by mechanical unloading.</br>\nConclusions</br>\nOur results showed that even short-term mechanical unloading is enough to decrease bone density, and mechanical unloading not only regulated the Scl expression but also changed the Scl distribution in both the osteocyte network and subcellular structures."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070570699974137093","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000413565973"}],"foaf:name":[{"@language":"en","@value":"Osumi, Ryuta"}]},{"@id":"https://cir.nii.ac.jp/crid/1070570699974137092","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000413565974"}],"foaf:name":[{"@language":"en","@value":"Wang, Ziyi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751165268480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70549881"},{"@type":"NRID","@value":"1000070549881"},{"@type":"NRID","@value":"9000002445039"},{"@type":"NRID","@value":"9000253672315"},{"@type":"NRID","@value":"9000006050033"},{"@type":"NRID","@value":"9000259071211"},{"@type":"NRID","@value":"9000368412703"},{"@type":"NRID","@value":"9000413565975"},{"@type":"NRID","@value":"9000410999807"},{"@type":"NRID","@value":"9000254480955"},{"@type":"NRID","@value":"9000024817438"},{"@type":"NRID","@value":"9000024207854"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000027113"}],"foaf:name":[{"@language":"en","@value":"Ishihara, Yoshihito"}]},{"@id":"https://cir.nii.ac.jp/crid/1070570699974137090","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000413565976"}],"foaf:name":[{"@language":"en","@value":"Odagaki, Naoya"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801194786304","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20282775"},{"@type":"NRID","@value":"1000020282775"},{"@type":"NRID","@value":"9000254852343"},{"@type":"NRID","@value":"9000022085793"},{"@type":"NRID","@value":"9000256428172"},{"@type":"NRID","@value":"9000002021159"},{"@type":"NRID","@value":"9000415169579"},{"@type":"NRID","@value":"9000410344405"},{"@type":"NRID","@value":"9000002302236"},{"@type":"NRID","@value":"9000259331306"},{"@type":"NRID","@value":"9000413565977"},{"@type":"NRID","@value":"9000408905664"},{"@type":"NRID","@value":"9000010232853"},{"@type":"NRID","@value":"9000254348255"},{"@type":"NRID","@value":"9000403424950"},{"@type":"NRID","@value":"9000022198406"},{"@type":"NRID","@value":"9000256428127"},{"@type":"NRID","@value":"9000018050359"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000014923"}],"foaf:name":[{"@language":"en","@value":"Iimura, Tadahiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801190299008","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80253219"},{"@type":"NRID","@value":"1000080253219"},{"@type":"NRID","@value":"9000308715268"},{"@type":"NRID","@value":"9000313611374"},{"@type":"NRID","@value":"9000303644367"},{"@type":"NRID","@value":"9000330667905"},{"@type":"NRID","@value":"9000335564877"},{"@type":"NRID","@value":"9000369737289"},{"@type":"NRID","@value":"9000368412705"},{"@type":"NRID","@value":"9000409467816"},{"@type":"NRID","@value":"9000000485094"},{"@type":"NRID","@value":"9000413565978"},{"@type":"NRID","@value":"9000240212232"},{"@type":"NRID","@value":"9000316696176"},{"@type":"NRID","@value":"9000409496023"},{"@type":"NRID","@value":"9000024297575"},{"@type":"NRID","@value":"9000297499567"},{"@type":"NRID","@value":"9000411380169"},{"@type":"NRID","@value":"9000012275781"},{"@type":"NRID","@value":"9000412202536"},{"@type":"NRID","@value":"9000412303438"},{"@type":"NRID","@value":"9000409579917"},{"@type":"NRID","@value":"9000410999812"},{"@type":"NRID","@value":"9000279213845"},{"@type":"NRID","@value":"9000413743200"},{"@type":"NRID","@value":"9000405916303"},{"@type":"NRID","@value":"9000010303464"},{"@type":"NRID","@value":"9000024817437"},{"@type":"NRID","@value":"9000403425051"},{"@type":"NRID","@value":"9000331418146"},{"@type":"NRID","@value":"9000398428425"},{"@type":"NRID","@value":"9000398421276"},{"@type":"NRID","@value":"9000305612242"},{"@type":"NRID","@value":"9000298264831"},{"@type":"NRID","@value":"9000403036655"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0184043"}],"foaf:name":[{"@language":"en","@value":"Kamioka, Hiroshi"}]}],"publication":{"publicationIdentifier":[{"@type":"ISSN","@value":"09148779"},{"@type":"PISSN","@value":"09148779"},{"@type":"EISSN","@value":"14355604"},{"@type":"NCID","@value":"AA10747551"}],"prism:publicationName":[{"@value":"Journal of Bone and Mineral Metabolism"}],"dc:publisher":[{"@value":"Springer"}],"prism:publicationDate":"2020-08-25","prism:volume":"39","prism:startingPage":"148","prism:endingPage":"159"},"reviewed":"false","url":[{"@id":"https://ousar.lib.okayama-u.ac.jp/60819"},{"@id":"https://link.springer.com/content/pdf/10.1007/s00774-020-01135-9.pdf"},{"@id":"https://link.springer.com/article/10.1007/s00774-020-01135-9/fulltext.html"},{"@id":"https://search.jamas.or.jp/link/ui/2022000448"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Sclerostin%20distribution","dc:title":"Sclerostin distribution"},{"@id":"https://cir.nii.ac.jp/all?q=Lacuno-canalicular%20system","dc:title":"Lacuno-canalicular system"},{"@id":"https://cir.nii.ac.jp/all?q=Mechanical%20unloading","dc:title":"Mechanical unloading"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@value":"Sclerostin distribution"}]},{"subjectScheme":"Other","notation":[{"@value":"Lacuno-canalicular system"}]},{"subjectScheme":"Other","notation":[{"@value":"Mechanical unloading"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256934556032","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04413"},{"@type":"JGN","@value":"JP17H04413"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04413/"}],"notation":[{"@language":"ja","@value":"骨細胞性骨溶解を基軸とした歯牙移動制御機構の解明"},{"@language":"en","@value":"Regulation of tooth movement-initiated mechanotransduction via osteocytic bone 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mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368501525120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>In situ</i>\n            measurement of solute transport in the bone lacunar-canalicular system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370783725056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843680878208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844608110592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, 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