{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050577386786937088.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/10458/00010600"}},{"identifier":{"@type":"URI","@value":"https://miyazaki-u.repo.nii.ac.jp/records/6749"}},{"identifier":{"@type":"DOI","@value":"10.1016/j.celrep.2023.112431"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2211124723004424?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2211124723004424?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"37099426"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells"}],"dc:language":"en","description":[{"type":"Other","notation":[{"@value":"application/pdf"}]},{"type":"Abstract","notation":[{"@value":"While dysbiosis in the gut is implicated in the impaired induction of oral tolerance generated in mesenteric lymph nodes （MesLNs）, how dysbiosis affects this process remains unclear. Here, we describe that antibiotic-driven gut dysbiosis causes the dysfunction of CD11c+CD103+ conventional dendritic cells （cDCs） in MesLNs, preventing the establishment of oral tolerance. Deficiency of CD11c+CD103+ cDCs abrogates the generation of regulatory T cells in MesLNs to establish oral tolerance. Antibiotic treatment triggers the intestinal dysbiosis linked to the impaired generation of colony-stimulating factor 2 （Csf2）-producing group 3 innate lymphoid cells （ILC3s） for regulating the tolerogenesis of CD11c+CD103+ cDCs and the reduced expression of tumor necrosis factor （TNF）-like ligand 1A （TL1A） on CD11c+CD103+ cDCs for generating Csf2-producing ILC3s. Thus, antibiotic-driven intestinal dysbiosis leads to the breakdown of crosstalk between CD11c+CD103+ cDCs and ILC3s for maintaining the tolerogenesis of CD11c+CD103+ cDCs in MesLNs, responsible for the failed establishment of oral tolerance."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030285133573233408","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90640962"},{"@type":"NRID","@value":"1000090640962"},{"@type":"NRID","@value":"9000243857340"},{"@type":"NRID","@value":"9000313615223"},{"@type":"NRID","@value":"9000345383782"},{"@type":"NRID","@value":"9000370759357"},{"@type":"NRID","@value":"9000272634522"},{"@type":"NRID","@value":"9000383068698"},{"@type":"NRID","@value":"9000383068706"},{"@type":"NRID","@value":"9000404094644"},{"@type":"NRID","@value":"9000409993565"},{"@type":"NRID","@value":"9000411799898"},{"@type":"NRID","@value":"9000345383776"},{"@type":"NRID","@value":"9000399813912"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/narantsog"}],"foaf:name":[{"@language":"en","@value":"Choijookhuu, Narantsog"},{"@language":"ja","@value":"チヨウジヨウフ, ナランツオツク"},{"@language":"ja-Kana","@value":"チヨウジヨウフ, 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善隆"},{"@language":"ja-Kana","@value":"ヒシカワ, ヨシタカ"},{"@language":"en","@value":"Hishikawa, Yoshitaka"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of 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克明"},{"@language":"ja-Kana","@value":"サトウ, カツアキ"},{"@language":"en","@value":"Sato, Katsuaki"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751148747392","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20624323"},{"@type":"NRID","@value":"1000020624323"},{"@type":"NRID","@value":"9000018221149"},{"@type":"NRID","@value":"9000411774298"},{"@type":"NRID","@value":"9000324995278"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000027278"}],"foaf:name":[{"@language":"ja","@value":"深谷, 知宏"},{"@language":"ja-Kana","@value":"フカヤ, トモヒロ"},{"@language":"en","@value":"Fukaya, Tomohiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of 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ヒデアキ"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801196690432","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30827374"},{"@type":"NRID","@value":"1000030827374"}],"foaf:name":[{"@language":"ja","@value":"西川, 陽太郎"},{"@language":"ja-Kana","@value":"ニシカワ, ヨウタロウ"},{"@language":"en","@value":"Nishikawa, Yotaro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1070021481843050115","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"冨永, 萌"},{"@language":"ja-Kana","@value":"トミナガ, モエ"},{"@language":"en","@value":"Tominaga, Moe"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]}],"publication":{"publicationIdentifier":[{"@type":"ISSN","@value":"22111247"},{"@type":"PISSN","@value":"22111247"}],"prism:publicationName":[{"@language":"en","@value":"Cell Reports"}],"dc:publisher":[{"@value":"Elsevier"}],"prism:publicationDate":"2023-05-30","prism:volume":"42","prism:number":"5","prism:startingPage":"112431"},"reviewed":"false","dc:rights":["© 2023 The Author(s)."],"url":[{"@id":"https://miyazaki-u.repo.nii.ac.jp/records/6749"},{"@id":"https://api.elsevier.com/content/article/PII:S2211124723004424?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2211124723004424?httpAccept=text/plain"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=dendritic%20cell","dc:title":"dendritic cell"},{"@id":"https://cir.nii.ac.jp/all?q=tolerogenesis","dc:title":"tolerogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=oral%20tolerance","dc:title":"oral tolerance"},{"@id":"https://cir.nii.ac.jp/all?q=mesenteric%20lymph%20nodes","dc:title":"mesenteric lymph nodes"},{"@id":"https://cir.nii.ac.jp/all?q=dysbiosis","dc:title":"dysbiosis"},{"@id":"https://cir.nii.ac.jp/all?q=innate%20lymphoid%20cells","dc:title":"innate lymphoid cells"},{"@id":"https://cir.nii.ac.jp/all?q=colony-stimulating%20factor%202","dc:title":"colony-stimulating factor 2"},{"@id":"https://cir.nii.ac.jp/all?q=TNF-like%20ligand%201A","dc:title":"TNF-like ligand 1A"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"dendritic cell"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"tolerogenesis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"oral tolerance"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"mesenteric lymph nodes"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"dysbiosis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"innate lymphoid cells"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"colony-stimulating factor 2"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"TNF-like ligand 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in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043903224064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Widespread recombinase expression using FLPeR (Flipper) mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044661548928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044695887616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046053953920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dendritic cells in 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