Hypoxia inducible factor-1a promotes trichogenic gene expression in human dermal papilla cells

DOI DOI 機関リポジトリ 機関リポジトリ (HANDLE) PDF ほか4件をすべて表示 一部だけ表示 被引用文献5件 参考文献32件 オープンアクセス
  • Seo, Jieun
    Fac Engn, Yokohama National University Fac Engn, Kanagawa Academy Science & Technology
  • Yan, Lei
    Fac Engn, Yokohama National University Fac Engn, Kanagawa Academy Science & Technology
  • Kageyama, Tatsuto
    Fac Engn, Yokohama National University Fac Engn, Kanagawa Academy Science & Technology
  • Nanmo, Ayaka
    Fac Engn, Yokohama National University
  • Chun, Yang-Sook
    Fac Engn, Coll Med, Dept Biomed Sci, Seoul National University (SNU)
  • Fukuda, Junji
    Fac Engn, Yokohama National University Fac Engn, Kanagawa Academy Science & Technology

書誌事項

タイトル別名
  • Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells
公開日
2023-01-27
資源種別
journal article
権利情報
  • Creative Commons Attribution 4.0 International
DOI
  • 10.1038/s41598-023-28837-0
  • 10.21203/rs.3.rs-2263496/v1
公開者
Nature Portfolio

この論文をさがす

説明

Dermal papilla cells (DPCs) play critical roles in hair follicle development, but the underlying mechanisms that contribute to hair regeneration have yet to be fully elucidated, particularly in terms of alterations in androgenetic alopecia patients. In this study, we demonstrated that hypoxia-inducible factor-1 alpha (HIF-1 alpha) is suppressed in scalp tissues of androgenetic alopecia patients and potentially associated with hair follicle development. Using RT-qPCR and western blot, we found that mRNA and protein levels of trichogenic genes, LEF1 and versican (VCAN), were attenuated in HIF-1 alpha knockdown DPCs. Under an in vivo mimicked environment in a three-dimensional spheroid culture, HIF-1 alpha-suppressed DPCs downregulated the expression of hair induction-related genes. Finally, treatment with a HIF-1 alpha activator resulted in the elevated expression of trichogenic genes in DPCs. This study highlights the importance of dermal HIF-1 alpha expression in regulating trichogenic genes and provides a promising therapeutic target and a fundamental tissue engineering approach for hair loss treatment.

収録刊行物

被引用文献 (5)*注記

もっと見る

参考文献 (32)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

問題の指摘

ページトップへ