A case study of risk-reduced salpingo-oophorectomy at single-center (Juntendo hospital)

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Other Title
  • 当院におけるリスク低減卵管卵巣摘出術(RRSO)を行った症例の検討
Published
2024-12-26
Resource Type
journal article
Publisher
静岡産科婦人科学会

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It is known that about 3% of patients with Hereditary Breast and Ovarian Cancer syndrome (HBOC) who underwent riskreducing salpingo-oophorectomy (RRSO) have serous tubal intraepithelial carcinoma(STIC) and about 4% have serous tubal intraepithelial lesion(STIL). In Japan, however, there are few reports on the pathological results after RRSO. In the present study, we retrospectively reviewed the clinical background and pathological findings of 35 patients who had BRCA1/2 variants and underwent RRSO from August 2015 to May 2022. Pathological variants in BRCA1 and BRCA2 were present in 22 and 13 cases, respectively. The median age at RRSO was 50.5 years. Three (8.6%) of the patients had STIC and 4 (11.4%) had STIL. All STIC cases had pathological variants in BRCA1, and 3 STIL cases had BRCA1 and 1 had BRCA2. No recurrence was observed in patients with STIC and STIL. The proportion of STIC and STIL was higher in this study than in previous reports. This is due to issues surrounding HBOC, such as insurance coverage for RRSO. In addition, there are no consistent guideline for the postoperative management of patients with STIC/STIL in pathology results, and nationwide future analysis is needed.

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