{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050584870604345088.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"https://hdl.handle.net/2324/7324208"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"033446532"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/033446532"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I033446532"}},{"identifier":{"@type":"DOI","@value":"10.2108/zs230098"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Gene Duplication of Androgen Receptor As An Evolutionary Driving Force Underlying the Diversity of Sexual Characteristics in Teleost Fishes"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"Sexual dimorphism allows species to meet their fitness optima based on the physiological availability of each sex. Although intralocus sexual conflict appears to be a genetic constraint for the evolution of sex-specific traits, sex-linked genes and the regulation of sex steroid hormones contribute to resolving this conflict by allowing sex-specific developments. Androgens and their receptor, androgen receptor (Ar), regulate male-biased phenotypes. In teleost fish, ar ohnologs have emerged as a result of teleost-specific whole genome duplication (TSGD). Recent studies have highlighted the evolutionary differentiation of ar ohnologs responsible for the development of sexual characteristics, which sheds light on the need for comparative studies on androgen regulation among different species. In this review, we discuss the importance of ar signaling as a regulator of male-specific traits in teleost species because teleost species are suitable experimental models for comparative studies owing to their great diversity in male-biased morphological and physiological traits. To date, both in vivo and in vitro studies on teleost ar ohnologs have shown a substantial influence of ars as a regulator of male-specific reproductive traits such as fin elongation, courtship behavior, and nuptial coloration. In addition to these sexual characteristics, ar substantially influences immunity, inducing a sex-biased immune response. This review aims to provide a comprehensive understanding of the current state of teleost ar studies and emphasizes the potential of teleost fishes, given their availability, to find molecular evidence about what gives rise to the spectacular diversity among fish species."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276172178944","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20779467"},{"@type":"NRID","@value":"1000020779467"},{"@type":"ORCID","@value":"0000-0003-2683-0160"},{"@type":"NRID","@value":"9000242104137"},{"@type":"NRID","@value":"9000341541715"},{"@type":"NRID","@value":"9000287286169"},{"@type":"NRID","@value":"9000242670916"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sansai"}],"foaf:name":[{"@language":"en","@value":"Ansai, Satoshi"},{"@language":"ja","@value":"安齋, 賢"},{"@language":"ja-Kana","@value":"アンサイ, サトシ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Genome Editing Breeding, Graduate School of Agriculture, Kyoto 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Miki"},{"@language":"ja","@value":"中尾, 実樹"},{"@language":"ja-Kana","@value":"ナカオ, ミキ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学大学院生物資源環境科学府生命機能科学専攻水族生化学研究室"},{"@language":"en","@value":"Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University"},{"@language":"ja","@value":"九州大学大学院農学研究院附属国際農業教育・研究推進センター"}]},{"@id":"https://cir.nii.ac.jp/crid/1070584870604345091","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kumar, Anu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Commonwealth Scientific and Industrial Research Organization, CSIRO 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Taisen"},{"@language":"ja","@value":"井口, 泰泉"},{"@language":"ja-Kana","@value":"イグチ, タイセン"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Graduate School of Nanobioscience, Yokohama City University"},{"@language":"ja","@value":"横浜市立大学"},{"@language":"en","@value":"Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University"},{"@language":"ja","@value":"金沢大学"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276180685056","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00404343"},{"@type":"NRID","@value":"1000000404343"},{"@type":"ORCID","@value":"0000-0003-3414-1648"},{"@type":"NRID","@value":"9000364746756"},{"@type":"NRID","@value":"9000316200950"},{"@type":"NRID","@value":"9000018516493"},{"@type":"NRID","@value":"9000007158964"},{"@type":"NRID","@value":"9000001612284"},{"@type":"NRID","@value":"9000408619855"},{"@type":"NRID","@value":"9000283623165"},{"@type":"NRID","@value":"9000253472149"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ogino-y"}],"foaf:name":[{"@language":"en","@value":"Ogino, Yukiko"},{"@language":"ja","@value":"荻野, 由紀子"},{"@language":"ja-Kana","@value":"オギノ, ユキコ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Aquatic Molecular Developmental Biology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学大学院生物資源環境科学府資源生物科学専攻水族分子発生学研究室"},{"@language":"en","@value":"Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University"},{"@language":"ja","@value":"九州大学大学院農学研究院附属国際農業教育・研究推進センター"}]},{"@id":"https://cir.nii.ac.jp/crid/1070584870604345089","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ryu, Tsukasa"},{"@language":"ja","@value":"リュウ, ツカサ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学大学院生物資源環境科学府生命機能科学専攻水族生化学研究室"}]},{"@id":"https://cir.nii.ac.jp/crid/1070584870604345093","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Okamoto, Keigo"},{"@language":"ja","@value":"岡本, 啓吾"},{"@language":"ja-Kana","@value":"オカモト, ケイゴ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Aquatic Molecular Developmental Biology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学大学院生物資源環境科学府資源生物科学専攻水族分子発生学研究室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02890003"},{"@type":"NDL_BIB_ID","@value":"000000131434"},{"@type":"ISSN","@value":"02890003"},{"@type":"NCID","@value":"AA10545874"}],"prism:publicationName":[{"@language":"en","@value":"Zoological Science"}],"dc:publisher":[{"@value":"Zoological Society of Japan"},{"@value":"日本動物学会"}],"prism:publicationDate":"2024-02-14","prism:volume":"41","prism:number":"1","prism:startingPage":"68","prism:endingPage":"76"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© 2024 Zoological Society of Japan"],"url":[{"@id":"http://id.ndl.go.jp/bib/033446532"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I033446532"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=sexual%20characteristics","dc:title":"sexual characteristics"},{"@id":"https://cir.nii.ac.jp/all?q=teleost","dc:title":"teleost"},{"@id":"https://cir.nii.ac.jp/all?q=androgen","dc:title":"androgen"},{"@id":"https://cir.nii.ac.jp/all?q=androgen%20receptor","dc:title":"androgen receptor"},{"@id":"https://cir.nii.ac.jp/all?q=whole%20genome%20duplication","dc:title":"whole genome duplication"},{"@id":"https://cir.nii.ac.jp/all?q=gene%20duplication","dc:title":"gene duplication"},{"@id":"https://cir.nii.ac.jp/all?q=immunity","dc:title":"immunity"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"sexual characteristics"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"teleost"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"androgen"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"androgen receptor"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"whole genome duplication"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"gene duplication"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"immunity"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781847515136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K07138"},{"@type":"JGN","@value":"JP15K07138"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07138/"}],"notation":[{"@language":"ja","@value":"アンドロゲン応答形質の多様化と適応の分子生物学的基盤"},{"@language":"en","@value":"Molecular basis of androgen dependent sex characteristics development and 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