{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050585803065415168.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/10458/0002001249"}},{"identifier":{"@type":"URI","@value":"https://miyazaki-u.repo.nii.ac.jp/records/2001249"}},{"identifier":{"@type":"DOI","@value":"10.1016/j.rpth.2025.102720"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2475037925000445?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2475037925000445?httpAccept=text/plain"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"Background\nNovel anticoagulants targeting coagulation factor (F)XI/activated FXI (FXIa) are currently under development. However, whether FXI is present in human deep vein thrombosis (DVT) and whether FXIa and activated FX (FXa) play different roles in venous thrombus formation and hemostasis remain unclear.\nObjectives\nTo determine the presence of FXI in DVT and the effects of direct oral FXIa and FXa inhibitors on venous thrombus formation and hemostasis in rabbits and on in vitro thrombus formation.\nMethods\nWe immunohistochemically assessed FXI localization in human-aspirated DVT (n = 15). Additionally, we compared thrombus formation induced by endothelial denudation and stenosis or stasis in the jugular vein and skin bleeding time and volume between rabbits treated with direct FXIa inhibitors (ONO-1600586) and FXa inhibitors (rivaroxaban). Ex vivo rabbit and human blood were perfused in a flow chamber under low-shear rates (70/s).\nResults\nFXI was localized in all DVT, predominantly in fibrin-rich areas. The FXI immunopositive area in the nonorganizing area was greater than that in the organizing area. Although FXIa and FXa inhibitors comparably inhibited venous thrombus formation, FXIa inhibitors did not affect bleeding time or volume in rabbits. FXIa or FXa inhibitors mildly or strongly inhibited fibrin formation at low-shear rates, respectively. Furthermore, the FXIa inhibitor suppressed human FXIa activity, thrombin generation, and fibrin formation during perfusion.\nConclusion\nThe pathologic findings of human DVT suggest FXI’s role in human DVT. FXIa inhibitors may inhibit less fibrin formation than FXa inhibitors and may explain the minor role of FXIa in hemostasis."}]},{"type":"Other","notation":[{"@language":"en","@value":"Citation: Nobuyuki Oguri, Toshihiro Gi, Eriko Nakamura, Kazunari Maekawa, Eiji Furukoji, Hoshimi Okawa, Sho Kouyama, Saki Horiuchi, Akira Sawaguchi, Tatefumi Sakae, Minako Azuma, Yujiro Asada, Atsushi Yamashita, Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis, Research and Practice in Thrombosis and Haemostasis, 9(2), 102720-102720, 2025-02, https://doi.org/10.1016/j.rpth.2025.102720"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070585803065415171","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Oguri, Nobuyuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751150031360","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30794656"},{"@type":"NRID","@value":"1000030794656"},{"@type":"NRID","@value":"9000414749168"},{"@type":"NRID","@value":"9000413572976"},{"@type":"NRID","@value":"9000411390495"},{"@type":"NRID","@value":"9000409862117"},{"@type":"NRID","@value":"9000365542186"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/miyazaki_patho_gi"}],"foaf:name":[{"@language":"ja","@value":"魏, 峻洸"},{"@language":"ja-Kana","@value":"ギ, トシヒロ"},{"@language":"en","@value":"Gi, Toshihiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420579599296820480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20981088"},{"@type":"NRID","@value":"1000020981088"},{"@type":"NRID","@value":"9000414220794"}],"foaf:name":[{"@language":"ja","@value":"中村, 恵理子"},{"@language":"ja-Kana","@value":"ナカムラ, エリコ"},{"@language":"en","@value":"Nakamura, Eriko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276162206464","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30754171"},{"@type":"NRID","@value":"1000030754171"},{"@type":"NRID","@value":"9000272995578"},{"@type":"NRID","@value":"9000365542185"},{"@type":"NRID","@value":"9000414220805"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/maekawakazunari"}],"foaf:name":[{"@language":"en","@value":"Maekawa, Kazunari"},{"@language":"ja","@value":"前川, 和也"},{"@language":"ja-Kana","@value":"マエカワ, カズナリ"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326216123264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00423723"},{"@type":"NRID","@value":"1000000423723"},{"@type":"NRID","@value":"9000014638849"},{"@type":"NRID","@value":"9000369343011"},{"@type":"NRID","@value":"9000397802103"},{"@type":"NRID","@value":"9000017178092"},{"@type":"NRID","@value":"9000415217194"},{"@type":"NRID","@value":"9000258275917"},{"@type":"NRID","@value":"9000002132447"},{"@type":"NRID","@value":"9000366122010"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000027432"}],"foaf:name":[{"@language":"ja","@value":"古小路, 英二"},{"@language":"ja-Kana","@value":"フルコウジ, エイジ"},{"@language":"en","@value":"Furukoji, Eiji"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1070585803065415173","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Okawa, Hoshimi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070585803065415177","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kouyama, Sho"}]},{"@id":"https://cir.nii.ac.jp/crid/1070585803065415170","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Horiuchi, Saki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801207138816","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30336292"},{"@type":"NRID","@value":"1000030336292"},{"@type":"NRID","@value":"9000414803119"},{"@type":"NRID","@value":"9000257888506"},{"@type":"NRID","@value":"9000006261362"},{"@type":"NRID","@value":"9000020088322"},{"@type":"NRID","@value":"9000406047899"},{"@type":"NRID","@value":"9000257887880"},{"@type":"NRID","@value":"9000241718084"},{"@type":"NRID","@value":"9000258010554"},{"@type":"NRID","@value":"9000326644178"},{"@type":"NRID","@value":"9000016383849"},{"@type":"NRID","@value":"9000263044349"},{"@type":"NRID","@value":"9000331430506"},{"@type":"NRID","@value":"9000383068696"},{"@type":"NRID","@value":"9000402392713"},{"@type":"NRID","@value":"9000415236290"},{"@type":"NRID","@value":"9000291598277"},{"@type":"NRID","@value":"9000404114184"},{"@type":"NRID","@value":"9000404105476"},{"@type":"NRID","@value":"9000258010562"},{"@type":"NRID","@value":"9000395364852"},{"@type":"NRID","@value":"9000395364870"},{"@type":"NRID","@value":"9000283916145"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0072768"}],"foaf:name":[{"@language":"ja","@value":"澤口, 朗"},{"@language":"ja-Kana","@value":"サワグチ, アキラ"},{"@language":"en","@value":"Sawaguchi, Akira"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1070021481843470593","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20347074"},{"@type":"NRID","@value":"1000020347074"}],"foaf:name":[{"@language":"ja","@value":"榮, 建文"},{"@language":"ja-Kana","@value":"サカエ, タテフミ"},{"@language":"en","@value":"Sakae, Tatefumi"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326205374848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00643389"},{"@type":"NRID","@value":"1000000643389"},{"@type":"NRID","@value":"9000361229083"},{"@type":"NRID","@value":"9000412285782"},{"@type":"NRID","@value":"9000022027988"},{"@type":"NRID","@value":"9000415153501"}],"foaf:name":[{"@language":"ja","@value":"東, 美菜子"},{"@language":"ja-Kana","@value":"アズマ, ミナコ"},{"@language":"en","@value":"Azuma, Minako"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658462547971","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70202588"},{"@type":"NRID","@value":"1000070202588"},{"@type":"NRID","@value":"9000413244661"},{"@type":"NRID","@value":"9000369343014"},{"@type":"NRID","@value":"9000240064157"},{"@type":"NRID","@value":"9000014526476"},{"@type":"NRID","@value":"9000262356869"},{"@type":"NRID","@value":"9000391584584"},{"@type":"NRID","@value":"9000377391653"},{"@type":"NRID","@value":"9000240064197"},{"@type":"NRID","@value":"9000257776153"},{"@type":"NRID","@value":"9000257777019"},{"@type":"NRID","@value":"9000410888882"},{"@type":"NRID","@value":"9000240516262"},{"@type":"NRID","@value":"9000391560510"},{"@type":"NRID","@value":"9000253371065"},{"@type":"NRID","@value":"9000257812616"},{"@type":"NRID","@value":"9000313200684"},{"@type":"NRID","@value":"9000351080994"},{"@type":"NRID","@value":"9000257812688"},{"@type":"NRID","@value":"9000415217197"},{"@type":"NRID","@value":"9000018992202"},{"@type":"NRID","@value":"9000398285678"},{"@type":"NRID","@value":"9000022001063"},{"@type":"NRID","@value":"9000391580707"},{"@type":"NRID","@value":"9000283446841"},{"@type":"NRID","@value":"9000391561651"},{"@type":"NRID","@value":"9000398251366"},{"@type":"NRID","@value":"9000283444411"},{"@type":"NRID","@value":"9000283344492"},{"@type":"NRID","@value":"9000261669312"},{"@type":"NRID","@value":"9000413244588"},{"@type":"NRID","@value":"9000391561124"},{"@type":"NRID","@value":"9000391580500"},{"@type":"NRID","@value":"9000254644246"},{"@type":"NRID","@value":"9000283446967"},{"@type":"NRID","@value":"9000257811906"},{"@type":"NRID","@value":"9000391584621"},{"@type":"NRID","@value":"9000345378752"},{"@type":"NRID","@value":"9000254644984"},{"@type":"NRID","@value":"9000254190683"},{"@type":"NRID","@value":"9000396136895"},{"@type":"NRID","@value":"9000256638932"},{"@type":"NRID","@value":"9000413244566"},{"@type":"NRID","@value":"9000391567166"},{"@type":"NRID","@value":"9000397688575"},{"@type":"NRID","@value":"9000283445451"},{"@type":"NRID","@value":"9000290820405"},{"@type":"NRID","@value":"9000415236294"},{"@type":"NRID","@value":"9000023933500"},{"@type":"NRID","@value":"9000255812633"},{"@type":"NRID","@value":"9000283349184"},{"@type":"NRID","@value":"9000257777483"},{"@type":"NRID","@value":"9000001449949"},{"@type":"NRID","@value":"9000413244839"},{"@type":"NRID","@value":"9000391585668"},{"@type":"NRID","@value":"9000369746177"},{"@type":"NRID","@value":"9000254645724"},{"@type":"NRID","@value":"9000241877125"},{"@type":"NRID","@value":"9000241526282"},{"@type":"NRID","@value":"9000021342284"},{"@type":"NRID","@value":"9000365542187"},{"@type":"NRID","@value":"9000254189487"},{"@type":"NRID","@value":"9000283349146"},{"@type":"NRID","@value":"9000257939089"},{"@type":"NRID","@value":"9000399800874"},{"@type":"NRID","@value":"9000256911658"},{"@type":"NRID","@value":"9000283558797"},{"@type":"NRID","@value":"9000391581193"},{"@type":"NRID","@value":"9000391583503"},{"@type":"NRID","@value":"9000312724970"},{"@type":"NRID","@value":"9000414220797"},{"@type":"NRID","@value":"9000256879594"},{"@type":"NRID","@value":"9000256635953"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0018720"}],"foaf:name":[{"@language":"en","@value":"Asada, Yujiro"},{"@language":"ja","@value":"浅田, 祐士郎"},{"@language":"ja-Kana","@value":"アサダ, ユウジロウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276179482112","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90372797"},{"@type":"NRID","@value":"1000090372797"},{"@type":"NRID","@value":"9000006643911"},{"@type":"NRID","@value":"9000369343010"},{"@type":"NRID","@value":"9000262356857"},{"@type":"NRID","@value":"9000009605049"},{"@type":"NRID","@value":"9000018845452"},{"@type":"NRID","@value":"9000313200679"},{"@type":"NRID","@value":"9000401988684"},{"@type":"NRID","@value":"9000257812684"},{"@type":"NRID","@value":"9000415217192"},{"@type":"NRID","@value":"9000019064916"},{"@type":"NRID","@value":"9000010009218"},{"@type":"NRID","@value":"9000398251365"},{"@type":"NRID","@value":"9000392422643"},{"@type":"NRID","@value":"9000405688058"},{"@type":"NRID","@value":"9000000779910"},{"@type":"NRID","@value":"9000257811903"},{"@type":"NRID","@value":"9000382068421"},{"@type":"NRID","@value":"9000345378751"},{"@type":"NRID","@value":"9000402039904"},{"@type":"NRID","@value":"9000396136893"},{"@type":"NRID","@value":"9000409862116"},{"@type":"NRID","@value":"9000399524362"},{"@type":"NRID","@value":"9000303645630"},{"@type":"NRID","@value":"9000350653469"},{"@type":"NRID","@value":"9000397688576"},{"@type":"NRID","@value":"9000258234995"},{"@type":"NRID","@value":"9000413846475"},{"@type":"NRID","@value":"9000377391764"},{"@type":"NRID","@value":"9000252930174"},{"@type":"NRID","@value":"9000415236289"},{"@type":"NRID","@value":"9000283349183"},{"@type":"NRID","@value":"9000014578659"},{"@type":"NRID","@value":"9000369746176"},{"@type":"NRID","@value":"9000021472117"},{"@type":"NRID","@value":"9000365542183"},{"@type":"NRID","@value":"9000254421708"},{"@type":"NRID","@value":"9000405898629"},{"@type":"NRID","@value":"9000283349145"},{"@type":"NRID","@value":"9000312724968"},{"@type":"NRID","@value":"9000302390332"},{"@type":"NRID","@value":"9000309183205"},{"@type":"NRID","@value":"9000414220798"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000027423"}],"foaf:name":[{"@language":"ja","@value":"山下, 篤"},{"@language":"ja-Kana","@value":"ヤマシタ, アツシ"},{"@language":"en","@value":"Yamashita, Atsushi"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"宮崎大学"},{"@language":"en","@value":"University of Miyazaki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"24750379"}],"prism:publicationName":[{"@language":"en","@value":"Research and Practice in Thrombosis and Haemostasis"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2025-02","prism:volume":"9","prism:number":"2","prism:startingPage":"102720"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© 2025 The Author(s)."],"url":[{"@id":"https://miyazaki-u.repo.nii.ac.jp/records/2001249"},{"@id":"https://api.elsevier.com/content/article/PII:S2475037925000445?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2475037925000445?httpAccept=text/plain"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=factor%20X","dc:title":"factor X"},{"@id":"https://cir.nii.ac.jp/all?q=factor%20XI","dc:title":"factor XI"},{"@id":"https://cir.nii.ac.jp/all?q=hemostasis","dc:title":"hemostasis"},{"@id":"https://cir.nii.ac.jp/all?q=pathology","dc:title":"pathology"},{"@id":"https://cir.nii.ac.jp/all?q=venous%20thromboembolism","dc:title":"venous thromboembolism"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"factor X"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"factor XI"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"hemostasis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"pathology"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"venous thromboembolism"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040295802073067008","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K06467"},{"@type":"JGN","@value":"JP23K06467"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06467/"}],"notation":[{"@language":"ja","@value":"肺血栓塞栓症における非塞栓部肺動脈の変化と静脈血栓由来因子の解明"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231987949824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143815206656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Plaque Instability Frequently Occurs Days or Weeks Before Occlusive Coronary Thrombosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144422456832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870445644288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histopathological Features of Cancer-Associated Venous Thromboembolism: Presence of Intrathrombus Cancer Cells and Prothrombotic Factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025436332811264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Model‐dependent contributions of FXII and FXI to venous thrombosis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617882354816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621344982144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of factor XI deficiency on ferric chloride‐induced vena cava thrombosis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643764446080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In situ strategy for biomedical target localization via nanogold nucleation and secondary growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306909479095296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Predictive value for increased activated factor XI activity in acute venous thromboembolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306909480331648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306913643638272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factor XI antigen and activity in human platelets"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095829337728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576121901954304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neutrophils can promote clotting via FXI and impact clot structure via neutrophil extracellular traps in a distinctive manner in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579819987298560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236933145472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588386268840064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ONO‐7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first‐in‐human study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570283705344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869862213042432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869864218930816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of rivaroxaban and warfarin on the risk of gastrointestinal bleeding and intracranial hemorrhage in patients with atrial fibrillation: Systematic review and meta‐analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869864225632256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Occurrence and management of severe bleeding episodes in patients with hereditary factor X deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044292771328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044747571072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global Burden of Thrombosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045550159488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elevated Factor XI Activity Levels Are Associated With an Increased Odds Ratio for Cerebrovascular Events"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944187222656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946286778624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419613265792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduced incidence of ischemic stroke in patients with severe factor XI deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420343609984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318839396736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320708876416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factor XI Activation in a Revised Model of Blood Coagulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268179304064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factor XI deficiency is associated with lower risk for cardiovascular and venous thromboembolism events"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268532330496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery"}]},{"@id":"https://cir.nii.ac.jp/crid/1370588379377486340","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of pathological heterogeneity on shear wave elasticity imaging in the staging of deep venous thrombosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390869622209365504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"止血機構と静脈血栓形成機序の相違：血液凝固XI因子からの視点"},{"@language":"en","@value":"Difference in mechanisms of hemostasis and thrombosis: A perspective from coagulation factor XI"}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:00851:0006784764"},{"@type":"CROSSREF","@value":"10.1016/j.rpth.2025.102720"},{"@type":"KAKEN","@value":"PRODUCT-25720940"},{"@type":"CROSSREF","@value":"10.2491/jjsth.36.771_references_DOI_6bPZ8aoC2fzgMu2DZRkrwMWXLU2"}]}