{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050587981427243136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"https://hdl.handle.net/2115/87635"}},{"identifier":{"@type":"DOI","@value":"10.1111/asj.13680"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/asj.13680"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/asj.13680"}},{"identifier":{"@type":"HANDLE","@value":"2115/87635"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2022320253"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effects of dietary vitamin K-3 supplementation on vitamin K-1 and K-2 (menaquinone) dynamics in dairy cows"},{"@value":"Effects of dietary vitamin K<sub>3</sub> supplementation on vitamin K<sub>1</sub> and K<sub>2</sub> (menaquinone) dynamics in dairy cows"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"The effect of dietary vitamin K-3 (VK3) on ruminant animals is not fully investigated. The aim of this study was to examine the effects of dietary VK3 on lactation performance, rumen characteristics, and VK1 and menaquinone (MK, or VK2) dynamics in the rumen, plasma, and milk of dairy cows. Eight Holstein dairy cows in late lactation periods were used in two crossover trials including a control (nontreatment) and a 50 or 200 mg/day (d) VK3 supplementation group. After 14 days, plasma, ruminal fluid, and milk were sampled and their VK1 and MKs contents were measured using fluorescence-high-performance liquid chromatography (HPLC). Milk production was unchanged after feeding 50 mg/day VK3 but marginally decreased after feeding 200 mg/day VK3. The molar ratio of propionate in ruminal fluid was significantly increased on feeding 200 mg/day VK3. Additionally, MK-4 concentrations significantly increased in both plasma and milk after VK3 feeding (50 and 200 mg/day). In ruminal fluid, MK-4 concentrations increased after 200 mg/day VK3 feeding. These results suggest that VK3 may be a good source of MK-4, the biologically active form of VK, in Holstein dairy cows during their late lactation periods. This study provides a basis for understanding the physiological role of VK in dairy cows."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326212119040","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60775443"},{"@type":"NRID","@value":"1000060775443"},{"@type":"NRID","@value":"9000018780461"},{"@type":"NRID","@value":"9000406309035"},{"@type":"NRID","@value":"9000382633160"},{"@type":"NRID","@value":"9000383068633"},{"@type":"NRID","@value":"9000410147814"},{"@type":"NRID","@value":"9000414071404"},{"@type":"NRID","@value":"9000403272636"},{"@type":"NRID","@value":"9000398292752"},{"@type":"NRID","@value":"9000412272922"},{"@type":"NRID","@value":"9000411074513"},{"@type":"NRID","@value":"9000256892347"},{"@type":"NRID","@value":"9000403545410"},{"@type":"NRID","@value":"9000413373304"},{"@type":"NRID","@value":"9000406309026"},{"@type":"NRID","@value":"9000414071331"},{"@type":"NRID","@value":"9000406034184"},{"@type":"NRID","@value":"9000387911555"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hbai"}],"foaf:name":[{"@language":"en","@value":"Bai, Hanako"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243145","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Arai, Hikoji"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243137","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ikuta, Kentarou"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243139","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ishikawa, Sho"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243136","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ohtani, Yoshihisa"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243146","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Iwashita, Kunihiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243138","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Okada, Nao"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276184740992","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40206280"},{"@type":"NRID","@value":"1000040206280"},{"@type":"CINII_AUTHOR_ID","@value":"DA18136749"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA18136749#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA18136749"},{"@type":"NRID","@value":"9000299860887"},{"@type":"NRID","@value":"9000019969845"},{"@type":"NRID","@value":"9000378108902"},{"@type":"NRID","@value":"9000021835044"},{"@type":"NRID","@value":"9000414751041"},{"@type":"NRID","@value":"9000411568493"},{"@type":"NRID","@value":"9000252814322"},{"@type":"NRID","@value":"9000414513575"},{"@type":"NRID","@value":"9000255961596"},{"@type":"NRID","@value":"9000253177989"},{"@type":"NRID","@value":"9000405125995"},{"@type":"NRID","@value":"9000406389058"},{"@type":"NRID","@value":"9000345223832"},{"@type":"NRID","@value":"9000406386368"},{"@type":"NRID","@value":"9000403258363"},{"@type":"NRID","@value":"9000410898718"},{"@type":"NRID","@value":"9000406386375"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0027300"}],"foaf:name":[{"@language":"en","@value":"Shirakawa, Hitoshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243142","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Komai, Michio"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243141","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Terada, Fuminori"}]},{"@id":"https://cir.nii.ac.jp/crid/1070587981427243140","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Obara, Yoshiaki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13443941"},{"@type":"EISSN","@value":"17400929"}],"prism:publicationName":[{"@language":"en","@value":"Animal science journal"}],"dc:publisher":[{"@value":"John Wiley & Sons"}],"prism:publicationDate":"2022-01-13","prism:volume":"93","prism:number":"1","prism:startingPage":"e13680"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["This is the peer reviewed version of the following article: Bai, H., Arai, H., Ikuta, K., Ishikawa, S., Ohtani, Y., Iwashita, K., Okada, N., Shirakawa, H., Komai, M., Terada, F., & Obara, Y. (2022). Effects of dietary vitamin K3 supplementation on vitamin K1 and K2 (menaquinone) dynamics in dairy cows. Animal Science Journal, 93( 1), e13680., which has been published in final form at https://doi.org/10.1111/asj.13680. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/asj.13680"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/asj.13680"},{"@id":"https://search.jamas.or.jp/link/ui/2022320253"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=dairy%20cow","dc:title":"dairy cow"},{"@id":"https://cir.nii.ac.jp/all?q=menaquinone-4","dc:title":"menaquinone-4"},{"@id":"https://cir.nii.ac.jp/all?q=milk%20production","dc:title":"milk production"},{"@id":"https://cir.nii.ac.jp/all?q=rumen%20fermentation","dc:title":"rumen fermentation"},{"@id":"https://cir.nii.ac.jp/all?q=vitamin%20K-3","dc:title":"vitamin K-3"}],"dcterms:subject":[{"subjectScheme":"NDC","notation":[{"@value":"610"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"dairy cow"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"menaquinone-4"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"milk production"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"rumen fermentation"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"vitamin K-3"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040566775672490624","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20H02928"},{"@type":"JGN","@value":"JP20H02928"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02928/"}],"notation":[{"@language":"ja","@value":"脳内活性型ビタミンKの認知機能増強作用と作用機序の解析"},{"@language":"en","@value":"Effect of endogenously converted vitamin K in brain on cognitive 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