{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050854065038696192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/267904"}},{"identifier":{"@type":"DOI","@value":"10.1038/s41536-022-00207-w"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41536-022-00207-w.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41536-022-00207-w"}},{"identifier":{"@type":"PMID","@value":"35110584"}},{"identifier":{"@type":"HANDLE","@value":"10668/19558"}},{"identifier":{"@type":"HANDLE","@value":"10261/270115"}},{"identifier":{"@type":"HANDLE","@value":"2433/267904"}},{"identifier":{"@type":"NAID","@value":"120007189267"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"The epicardium is a mesothelial layer covering the myocardium serving as a progenitor source during cardiac development. The epicardium reactivates upon cardiac injury supporting cardiac repair and regeneration. Fine-tuned balanced signaling regulates cell plasticity and cell-fate decisions of epicardial-derived cells (EPCDs) via epicardial-to-mesenchymal transition (EMT). However, powerful tools to investigate epicardial function, including markers with pivotal roles in developmental signaling, are still lacking. Here, we recapitulated epicardiogenesis using human induced pluripotent stem cells (hiPSCs) and identified type II classical cadherin CDH18 as a biomarker defining lineage specification in human active epicardium. The loss of CDH18 led to the onset of EMT and specific differentiation towards cardiac smooth muscle cells. Furthermore, GATA4 regulated epicardial CDH18 expression. These results highlight the importance of tracing CDH18 expression in hiPSC-derived epicardial cells, providing a model for investigating epicardial function in human development and disease and enabling new possibilities for regenerative medicine."}]},{"type":"Other","notation":[{"@language":"ja","@value":"CDH18は胎児期の心外膜細胞の指標であり胎児心外膜から平滑筋細胞の分化を制御している. 京都大学プレスリリース. 2022-02-09."}]},{"type":"Other","notation":[{"@language":"en","@value":"Using stem cells to regenerate the heart. 京都大学プレスリリース. 2022-02-09."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070854065038696197","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415326652"}],"foaf:name":[{"@language":"en","@value":"Junghof, Julia"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for iPS Cell Research and Application, Kyoto University; Graduate School of Medicine, Kyoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1070854065038696192","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415326653"}],"foaf:name":[{"@language":"en","@value":"Kogure, Yuta"},{"@language":"ja","@value":"小暮, 優太"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for iPS Cell Research and Application, Kyoto University; Research and Development Division, ROHTO Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1070854065038696196","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415326654"}],"foaf:name":[{"@language":"en","@value":"Tian, Yu"},{"@language":"ja","@value":"田, 雨"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for iPS Cell Research and Application, Kyoto University; Graduate School of Medicine, Kyoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1070854065038696193","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415326655"}],"foaf:name":[{"@language":"es","@value":"Verdugo-Sivianes, Eva María"}],"jpcoar:affiliationName":[{"@language":"es","@value":"Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas; CIBERONC, Instituto de Salud Carlos III"}]},{"@id":"https://cir.nii.ac.jp/crid/1070854065038696195","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415326656"}],"foaf:name":[{"@language":"en","@value":"Narita, Megumi"},{"@language":"ja","@value":"成田, 恵"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for iPS Cell Research and Application, Kyoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1070854065038696198","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415326657"}],"foaf:name":[{"@language":"en","@value":"Lucena-Cacace, Antonio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for iPS Cell Research and Application, Kyoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751159698432","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20447965"},{"@type":"NRID","@value":"1000020447965"},{"@type":"ORCID","@value":"0000-0001-5511-9090"},{"@type":"NRID","@value":"9000402817155"},{"@type":"NRID","@value":"9000022285127"},{"@type":"NRID","@value":"9000335565749"},{"@type":"NRID","@value":"9000411564937"},{"@type":"NRID","@value":"9000003916314"},{"@type":"NRID","@value":"9000367402645"},{"@type":"NRID","@value":"9000312251425"},{"@type":"NRID","@value":"9000256911609"},{"@type":"NRID","@value":"9000412525381"},{"@type":"NRID","@value":"9000331448654"},{"@type":"NRID","@value":"9000242120199"},{"@type":"NRID","@value":"9000402582019"},{"@type":"NRID","@value":"9000412151309"},{"@type":"NRID","@value":"9000376923536"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000008886"}],"foaf:name":[{"@language":"en","@value":"Yoshida, Yoshinori"},{"@language":"ja","@value":"吉田, 善紀"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for iPS Cell Research and Application, Kyoto University"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1890866215846304261","@type":"Researcher","foaf:name":[{"@value":"Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]"}]},{"@id":"https://cir.nii.ac.jp/crid/1890866215846304260","@type":"Researcher","foaf:name":[{"@value":"小暮, 優太"}]},{"@id":"https://cir.nii.ac.jp/crid/1890866215846304259","@type":"Researcher","foaf:name":[{"@value":"田, 雨"}]},{"@id":"https://cir.nii.ac.jp/crid/1890866215846304257","@type":"Researcher","foaf:name":[{"@value":"成田, 恵"}]},{"@id":"https://cir.nii.ac.jp/crid/1890866215846304258","@type":"Researcher","foaf:name":[{"@value":"吉田, 善紀"}]},{"@id":"https://cir.nii.ac.jp/crid/1890866215846304256","@type":"Researcher","foaf:name":[{"@value":"20447965"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981772","@type":"Researcher","foaf:name":[{"@value":"Ministry of Education, Culture, Sports, Science and Technology (Japan)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981771","@type":"Researcher","foaf:name":[{"@value":"Fondation Leducq"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981768","@type":"Researcher","foaf:name":[{"@value":"Japan Society for the Promotion of Science"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981763","@type":"Researcher","foaf:name":[{"@value":"Research Center Network for Realization of Regenerative Medicine (Japan)"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981770","@type":"Researcher","foaf:name":[{"@value":"Japan Agency of Medical Research and Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981769","@type":"Researcher","foaf:name":[{"@value":"iPS Cell Research Fund"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067664981761","@type":"Researcher","foaf:name":[{"@value":"Secom Science and Technology Foundation"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20573995"}],"prism:publicationName":[{"@language":"en","@value":"npj Regenerative Medicine"}],"dc:publisher":[{"@value":"Springer Nature"}],"prism:publicationDate":"2022","prism:volume":"7"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© The Author(s) 2022","This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder."],"url":[{"@id":"https://www.nature.com/articles/s41536-022-00207-w.pdf"},{"@id":"https://www.nature.com/articles/s41536-022-00207-w"},{"@id":"http://hdl.handle.net/2433/267904"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cell%20signalling","dc:title":"Cell signalling"},{"@id":"https://cir.nii.ac.jp/all?q=Regenerative%20medicine","dc:title":"Regenerative medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Stem-cell%20differentiation","dc:title":"Stem-cell differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Transcriptomics","dc:title":"Transcriptomics"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Cell signalling"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Regenerative medicine"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Stem-cell differentiation"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Transcriptomics"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040003825728361472","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K17078"},{"@type":"JGN","@value":"JP20K17078"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17078/"}],"notation":[{"@language":"ja","@value":"Human induced pluripotent stem cell derived cardiomyocyte maturation by DNA integrative free-delivery of key regulators"},{"@language":"en","@value":"Human induced pluripotent stem cell derived cardiomyocyte maturation by DNA integrative free-delivery of key regulators"}]},{"@id":"https://cir.nii.ac.jp/crid/1040006432272725120","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21H02912"},{"@type":"JGN","@value":"JP21H02912"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02912/"}],"notation":[{"@language":"ja","@value":"心外膜細胞の増殖分化制御メカニズムの解明とその応用技術の開発"},{"@language":"en","@value":"Elucidating Mechanisms of Epicardial Cell Proliferation and Differentiation and Developing Technologies for Their Application"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256934242048","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04176"},{"@type":"JGN","@value":"JP17H04176"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04176/"}],"notation":[{"@language":"ja","@value":"多能性幹細胞由来心筋細胞の細胞周期制御のための統合的アプローチ"},{"@language":"en","@value":"An integrated approach for cell cycle control of pluripotent stem cell-derived cardiomyocytes"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810809471616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285690822016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors."},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblasts cultures by defined factors"},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblasts by defined factors"},{"@value":"Induction of pluripotent stem cells from mouse embryonic, adult fibroblast cultures by defined factors"},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [Journal Article]"},{"@value":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblastic cultures by defined factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017284623613440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role of Transcription Factor 21 in Epicardial Cell Differentiation and the Development of Coronary Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017285941480960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017289457063936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360282588966280320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cadherins in development: cell adhesion, sorting, and tissue morphogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618712406272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adult mouse epicardium modulates myocardial injury by secreting paracrine factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618720108416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distinct Compartments of the Proepicardial Organ Give Rise to Coronary Vascular Endothelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618964308736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298759595815808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coronary vessel formation in development and disease: mechanisms and insights for therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298763918292864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardium and Myocardium Originate From a Common Cardiogenic Precursor Pool"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298763918500736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298763919564672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardial TGFβ and BMP Signaling in Cardiac Regeneration: What Lesson Can We Learn from the Developing Heart?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096288072704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generation of the epicardial lineage from human pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576120217124864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The extracellular matrix in development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579820111191040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of <i>Bmp4</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580234568258688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of smooth muscle cells in Cardiovascular Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235277641856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235278645760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235278816512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human fetal and adult epicardial-derived cells: a novel model to study their activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235279020544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235911244672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Human Cadherin-14, a Novel Neurally Specific Type II Cadherin, by Protein Interaction Cloning"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236176361088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236411431680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Harnessing Epicardial Progenitor Cells and Their Derivatives for Rescue and Repair of Cardiac Tissue After Myocardial Infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236412204544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biochemical Characterization and Functional Analysis of Two Type II Classic Cadherins, Cadherin-6 and -14, and Comparison with E-cadherin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239287896704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biological characteristics of embryonic epicardial cells &lt;italic&gt;in vitro&lt;/italic&gt; correlate with embryonic day"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239288636160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Covering and Re-Covering the Heart: Development and Regeneration of the Epicardium"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569052870272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569353979904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569474772096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569650301824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569821454592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BMP Signals Promote Proepicardial Protrusion Necessary for Recruitment of Coronary Vessel and Epicardial Progenitors to the Heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571548679680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861710697024896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"R-cadherin Influences Cell Motility via Rho Family GTPases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861714635198720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Efficient Differentiation of TBX18\n                    <sup>+</sup>\n                    /WT1\n                    <sup>+</sup>\n                    Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043767422208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044677456768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"β-Catenin controls cell sorting at the notochord–somite boundary independently of cadherin-mediated adhesion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044779569664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045303814016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signaling During Epicardium and Coronary Vessel Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045337935616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epicardium-Derived Cells Contribute a Novel Population to the Myocardial Wall and the Atrioventricular Cushions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045520557568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cadherins guide migrating Purkinje cells to specific parasagittal domains during cerebellar development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045939673216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046512612736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518820797568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"WT1 regulates epicardial epithelial to mesenchymal 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