{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050855920197290752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2241/0002004776"}},{"identifier":{"@type":"URI","@value":"https://tsukuba.repo.nii.ac.jp/records/2004776"}},{"identifier":{"@type":"DOI","@value":"10.1038/s41467-021-25146-w"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-021-25146-w.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-021-25146-w"}},{"identifier":{"@type":"DOI","@value":"10.1101/2021.05.17.444252"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/2021.05.17.444252"}},{"identifier":{"@type":"PMID","@value":"34376687"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster"},{"@value":"The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in\n                  <i>Drosophila melanogaster</i>"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion of glucagon and insulins in mammals. Although glucagon-like and insulin-like hormones have been found across animal phyla, incretin-like EEC-derived hormones have not yet been characterised in invertebrates. Here, we show that the midgut-derived hormone, neuropeptide F (NPF), acts as the sugar-responsive, incretin-like hormone in the fruit fly,\n                    <jats:italic>Drosophila melanogaster</jats:italic>\n                    . Secreted NPF is received by NPF receptor in the corpora cardiaca and in insulin-producing cells. NPF-NPFR signalling resulted in the suppression of the glucagon-like hormone production and the enhancement of the insulin-like peptide secretion, eventually promoting lipid anabolism. Similar to the loss of incretin function in mammals, loss of midgut NPF led to significant metabolic dysfunction, accompanied by lipodystrophy, hyperphagia, and hypoglycaemia. These results suggest that enteroendocrine hormones regulate sugar-dependent metabolism through glucagon-like and insulin-like hormones not only in mammals but also in insects.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420011926324289408","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30961388"},{"@type":"NRID","@value":"1000030961388"},{"@type":"NRID","@value":"9000415346291"},{"@type":"NRID","@value":"9000414092489"},{"@type":"NRID","@value":"9000413512358"},{"@type":"NRID","@value":"9000413504808"},{"@type":"NRID","@value":"9000413472329"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yutoyoshinari"}],"foaf:name":[{"@language":"en","@value":"Yoshinari Yuto"}]},{"@id":"https://cir.nii.ac.jp/crid/1030299673841635328","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50962908"},{"@type":"NRID","@value":"1000050962908"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hinakosakamoto"}],"foaf:name":[{"@language":"en","@value":"Kosakamoto Hina"}]},{"@id":"https://cir.nii.ac.jp/crid/1070864280552750855","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kamiyama Takumi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070864280552750852","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hoshino Ryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1070864280552750851","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Matsuoka Rena"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326215012864","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90408401"},{"@type":"NRID","@value":"1000090408401"},{"@type":"NRID","@value":"9000415346293"},{"@type":"NRID","@value":"9000414092490"},{"@type":"NRID","@value":"9000008110433"},{"@type":"NRID","@value":"9000365542467"},{"@type":"NRID","@value":"9000255960857"},{"@type":"NRID","@value":"9000414922290"},{"@type":"NRID","@value":"9000413504810"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shukondo"}],"foaf:name":[{"@language":"en","@value":"Kondo Shu"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276188724736","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70714955"},{"@type":"NRID","@value":"1000070714955"},{"@type":"NRID","@value":"9000345423092"},{"@type":"NRID","@value":"9000415346294"},{"@type":"NRID","@value":"9000414092491"},{"@type":"NRID","@value":"9000000190649"},{"@type":"NRID","@value":"9000399595313"},{"@type":"NRID","@value":"9000241753825"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000009976"}],"foaf:name":[{"@language":"en","@value":"Tanimoto Hiromu"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751144964352","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90323245"},{"@type":"NRID","@value":"1000090323245"},{"@type":"NRID","@value":"9000414214402"},{"@type":"NRID","@value":"9000001945323"},{"@type":"NRID","@value":"9000017330955"},{"@type":"NRID","@value":"9000000848993"},{"@type":"NRID","@value":"9000004412756"},{"@type":"NRID","@value":"9000010089265"},{"@type":"NRID","@value":"9000414214346"},{"@type":"NRID","@value":"9000413503336"},{"@type":"NRID","@value":"9000019090356"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0118144"}],"foaf:name":[{"@language":"en","@value":"Nakamura Akira"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276185495936","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40748539"},{"@type":"NRID","@value":"1000040748539"},{"@type":"NRID","@value":"9000251861544"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/obataf"}],"foaf:name":[{"@language":"en","@value":"Obata Fumiaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326222911616","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60507945"},{"@type":"NRID","@value":"1000060507945"},{"@type":"ORCID","@value":"0000-0002-1716-455X"},{"@type":"NRID","@value":"9000391396964"},{"@type":"NRID","@value":"9000325821877"},{"@type":"NRID","@value":"9000018525607"},{"@type":"NRID","@value":"9000415346297"},{"@type":"NRID","@value":"9000413471963"},{"@type":"NRID","@value":"9000412227760"},{"@type":"NRID","@value":"9000000189989"},{"@type":"NRID","@value":"9000413527955"},{"@type":"NRID","@value":"9000413527952"},{"@type":"NRID","@value":"9000325821986"},{"@type":"NRID","@value":"9000018470500"},{"@type":"NRID","@value":"9000006493841"},{"@type":"NRID","@value":"9000413534574"},{"@type":"NRID","@value":"9000413534573"},{"@type":"NRID","@value":"9000413475600"},{"@type":"NRID","@value":"9000413475602"},{"@type":"NRID","@value":"9000414214347"},{"@type":"NRID","@value":"9000413470425"},{"@type":"NRID","@value":"9000413475817"},{"@type":"NRID","@value":"9000403311201"},{"@type":"NRID","@value":"9000413512356"},{"@type":"NRID","@value":"9000413512360"},{"@type":"NRID","@value":"9000413523685"},{"@type":"NRID","@value":"9000413523692"},{"@type":"NRID","@value":"9000237725309"},{"@type":"NRID","@value":"9000018129147"},{"@type":"NRID","@value":"9000261040021"},{"@type":"NRID","@value":"9000413530849"},{"@type":"NRID","@value":"9000413530843"},{"@type":"NRID","@value":"9000415346286"},{"@type":"NRID","@value":"9000241515906"},{"@type":"NRID","@value":"9000413489066"},{"@type":"NRID","@value":"9000413482439"},{"@type":"NRID","@value":"9000413482441"},{"@type":"NRID","@value":"9000018536392"},{"@type":"NRID","@value":"9000413524141"},{"@type":"NRID","@value":"9000413524132"},{"@type":"NRID","@value":"9000413523017"},{"@type":"NRID","@value":"9000413523019"},{"@type":"NRID","@value":"9000413504814"},{"@type":"NRID","@value":"9000413504806"},{"@type":"NRID","@value":"9000413472328"},{"@type":"NRID","@value":"9000255960859"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/niwaryusuke"}],"foaf:name":[{"@language":"en","@value":"Niwa Ryusuke"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"},{"@type":"PISSN","@value":"20411723"},{"@type":"NCID","@value":"AA12645905"}],"prism:publicationName":[{"@language":"en","@value":"Nature Communications"}],"dc:publisher":[{"@value":"Nature Research"}],"prism:publicationDate":"2021-08","prism:volume":"12","prism:startingPage":"4818"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["(c) The Author(s) 2021","This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/."],"url":[{"@id":"https://tsukuba.repo.nii.ac.jp/records/2004776"},{"@id":"https://www.nature.com/articles/s41467-021-25146-w.pdf"},{"@id":"https://www.nature.com/articles/s41467-021-25146-w"},{"@id":"https://syndication.highwire.org/content/doi/10.1101/2021.05.17.444252"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Neuropeptide","dc:title":"Receptors, Neuropeptide"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Enteroendocrine%20Cells","dc:title":"Enteroendocrine Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=Neuropeptides","dc:title":"Neuropeptides"},{"@id":"https://cir.nii.ac.jp/all?q=Glucagon","dc:title":"Glucagon"},{"@id":"https://cir.nii.ac.jp/all?q=Lipid%20Metabolism","dc:title":"Lipid Metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=Incretins","dc:title":"Incretins"},{"@id":"https://cir.nii.ac.jp/all?q=Hormones","dc:title":"Hormones"},{"@id":"https://cir.nii.ac.jp/all?q=Hypoglycemia","dc:title":"Hypoglycemia"},{"@id":"https://cir.nii.ac.jp/all?q=Animals,%20Genetically%20Modified","dc:title":"Animals, Genetically Modified"},{"@id":"https://cir.nii.ac.jp/all?q=Drosophila%20melanogaster","dc:title":"Drosophila melanogaster"},{"@id":"https://cir.nii.ac.jp/all?q=Glucagon-Like%20Peptide%201","dc:title":"Glucagon-Like Peptide 1"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin%20Secretion","dc:title":"Insulin Secretion"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Insulin","dc:title":"Insulin"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Sugars","dc:title":"Sugars"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782014658304","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H03367"},{"@type":"JGN","@value":"JP19H03367"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03367/"}],"notation":[{"@language":"ja","@value":"神経の栄養プログラミング機構の解明"},{"@language":"en","@value":"Mechanism of nutritional programming in neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1040285300694446080","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20H00519"},{"@type":"JGN","@value":"JP20H00519"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00519/"}],"notation":[{"@language":"ja","@value":"学習依存的に合成されるタンパク質の同定と記憶の長期化における動態の解明"},{"@language":"en","@value":"Translational regulation enhances distinction of cell types in the nervous 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signaling via free fatty acid receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1050021868454147584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282677520702464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1050577541485162368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila"},{"@value":"Circulating fructose regulates a germline stem cell increase via gustatory receptor–mediated gut hormone secretion in mated\n                    <i>Drosophila</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360001114003975424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prandiology of\n                    <i>Drosophila</i>\n                    and the CAFE assay"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232095367296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235503153920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rapid and efficient generation of <scp>GFP</scp>‐knocked‐in 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article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172420756864","@type":"Article","resourceType":"preprint","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The gut hormone Allatostatin C regulates food intake and metabolic homeostasis under nutrient stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172715744896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuronal Gluconeogenesis Regulates Systemic Glucose Homeostasis in Drosophila melanogaster"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172719689344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discovering human diabetes-risk gene function with genetics and physiological 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article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nutrient responding peptide hormone CCHamide-2 consolidates appetitive memory"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390740691456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360282589142584960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quantifying Drosophila food intake: comparative analysis of current methodology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708506277120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617914638208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618956456832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618986002816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294645693916800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294646611592320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of insulin and adipokinetic hormone/glucagon production in flies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294647646195328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegypti"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294648189683328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A cell atlas of the adult\n                    <i>Drosophila</i>\n                    midgut"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294648226692608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incretins in obesity and diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866889398784","@type":"Article","resourceType":"学術雑誌論文(journal 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