{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050861925321865856.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/286733"}},{"identifier":{"@type":"DOI","@value":"10.1016/j.xjon.2022.11.001"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2666273622003734?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2666273622003734?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"36590714"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"OBJECTIVES: Acute kidney injury is a serious complication after cardiovascular surgery requiring circulatory arrest. It is reported that mice can be induced into a hibernation-like hypometabolic state by stimulating a specific neuron located at the hypothalamus (quiescence-inducing neurons-induced hypometabolism [QIH]). Here, we investigated the efficacy of QIH for the amelioration of acute kidney injury in an experimental circulatory arrest using a transgenic mouse model. METHODS: We genetically prepared mice in which QIH can be conditionally induced (QIH-ready mice). Mice were divided into 4 groups (n=6 for each): QIH-ready normothermia (QN), QIH-ready hypothermia (QH), control normothermia (CN), and control hypothermia (CH). After induction of QIH, left thoracotomy and descending aorta crossclamping were conducted. After reperfusion, we collected kidneys and evaluated histologic changes and serum biochemical markers, specifically neutrophil gelatinase-associated lipocalin and cystatin C, indicating early kidney injury. RESULTS: Normothermia showed higher tubular injury scores than those in hypothermia (QN vs QH [P=.0021] and CN vs CH [P<.001]). QN exhibited lower neutrophil gelatinase-associated lipocalin and cystatin C levels than those in CN (neutrophil gelatinase-associated lipocalin: CN vs QN: 1.51±0.71 vs 0.82±0.32; P=.0414 and cystatin C: 1.48±0.39 vs 0.71±0.26; P=.0015). There was no significant difference between QN and QH. CONCLUSIONS: QIH partly ameliorated acute kidney injury in a mouse ischemia model even in normothermia. QIH might be a promising approach to achieving sufficient kidney protection without hypothermic circulatory arrest in the future."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070861925321865857","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kyo, Shoichi"},{"@language":"ja","@value":"許, 敞一"}]},{"@id":"https://cir.nii.ac.jp/crid/1420285329318127744","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80884329"},{"@type":"NRID","@value":"1000080884329"},{"@type":"NRID","@value":"9000397698274"},{"@type":"NRID","@value":"9000367053941"},{"@type":"NRID","@value":"9000331448539"},{"@type":"NRID","@value":"9000347162603"},{"@type":"NRID","@value":"9000323308430"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kozuemurata"}],"foaf:name":[{"@language":"en","@value":"Murata, Kozue"},{"@language":"ja","@value":"村田, 梢"}]},{"@id":"https://cir.nii.ac.jp/crid/1070861925321865860","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kawatou, Masahide"},{"@language":"ja","@value":"川東, 正英"}]},{"@id":"https://cir.nii.ac.jp/crid/1070861925321865856","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Minatoya, Kenji"},{"@language":"ja","@value":"湊谷, 謙司"}]},{"@id":"https://cir.nii.ac.jp/crid/1070861925321865861","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sunagawa, Genshiro A."}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751154360320","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70645754"},{"@type":"NRID","@value":"1000070645754"},{"@type":"ORCID","@value":"0000-0002-4059-2827"},{"@type":"NRID","@value":"9000019174773"},{"@type":"NRID","@value":"9000005850341"},{"@type":"NRID","@value":"9000242794869"},{"@type":"NRID","@value":"9000001463324"},{"@type":"NRID","@value":"9000410918834"},{"@type":"NRID","@value":"9000003913674"},{"@type":"NRID","@value":"9000253459100"},{"@type":"NRID","@value":"9000350558229"},{"@type":"NRID","@value":"9000399545330"},{"@type":"NRID","@value":"9000356514595"},{"@type":"NRID","@value":"9000389446379"},{"@type":"NRID","@value":"9000369354228"},{"@type":"NRID","@value":"9000331448503"},{"@type":"NRID","@value":"9000323291089"},{"@type":"NRID","@value":"9000024678923"},{"@type":"NRID","@value":"9000253459784"},{"@type":"NRID","@value":"9000403550050"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000018347"}],"foaf:name":[{"@language":"en","@value":"Masumoto, Hidetoshi"},{"@language":"ja","@value":"升本, 英利"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"26662736"},{"@type":"PISSN","@value":"26662736"}],"prism:publicationName":[{"@language":"en","@value":"JTCVS Open"}],"dc:publisher":[{"@value":"Elsevier BV"},{"@value":"The American Association for Thoracic Surgery"}],"prism:publicationDate":"2022-12","prism:volume":"12","prism:startingPage":"201","prism:endingPage":"210"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© 2022 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","This is an open access article under the CC BY license."],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2666273622003734?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2666273622003734?httpAccept=text/plain"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=circulatory%20arrest","dc:title":"circulatory arrest"},{"@id":"https://cir.nii.ac.jp/all?q=acute%20kidney%20injury","dc:title":"acute kidney injury"},{"@id":"https://cir.nii.ac.jp/all?q=hibernation","dc:title":"hibernation"},{"@id":"https://cir.nii.ac.jp/all?q=Q%20neurons-induced%20hypometabolism","dc:title":"Q neurons-induced hypometabolism"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"circulatory arrest"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"acute kidney injury"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"hibernation"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Q neurons-induced hypometabolism"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040851707391433344","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K18276"},{"@type":"JGN","@value":"JP21K18276"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K18276/"}],"notation":[{"@language":"ja","@value":"冬眠による急性疾患の進行抑制・予後改善への挑戦"},{"@language":"en","@value":"Can hibernation delay acute illness and improve outcome?"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231989835520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017288787210880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Slit2 Prevents Neutrophil Recruitment and Renal Ischemia-Reperfusion Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619402368768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GENERAL HYPOTHERMIA FOR EXPERIMENTAL INTRACARDIAC SURGERY"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298344246868480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Does moderate hypothermia really carry less bleeding risk than deep hypothermia for circulatory arrest? 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