Reprogramming of three-dimensional microenvironments for <i>in vitro</i> hair follicle induction

DOI DOI 機関リポジトリ 機関リポジトリ (HANDLE) Web Site ほか2件をすべて表示 一部だけ表示 被引用文献10件 参考文献53件 オープンアクセス

書誌事項

タイトル別名
  • Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction
公開日
2022-10-21
資源種別
journal article
権利情報
  • Creative Commons Attribution 4.0 International
DOI
  • 10.1126/sciadv.add4603
  • 10.1101/2022.06.13.495917
公開者
American Association for the Advancement of Science (AAAS)

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説明

During embryonic development, reciprocal interactions between epidermal and mesenchymal layers trigger hair follicle morphogenesis. This study revealed that microenvironmental reprogramming via control over these interactions enabled hair follicle induction in vitro. A key approach is to modulate spatial distributions of epithelial and mesenchymal cells in their spontaneous organization. The de novo hair follicles with typical morphological features emerged in aggregates of the two cell types, termed hair follicloids, and hair shafts sprouted with near 100% efficiency in vitro. The hair shaft length reached similar to 3 mm in culture. Typical trichogenic signaling pathways were up-regulated in hair follicloids. Owing to replication of hair follicle morphogenesis in vitro, melanosome production and transportation were also monitored in the hair bulb region. This in vitro hair follicle model might be valuable for better understanding hair follicle induction, evaluating hair growth and inhibition of hair growth by drugs, and modeling gray hairs in a well-defined environment.

収録刊行物

  • Science Advances

    Science Advances 8 (42), eadd4603-, 2022-10-21

    American Association for the Advancement of Science (AAAS)

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