Effects of oxytocin on the hair growth ability of dermal papilla cells

DOI 機関リポジトリ 機関リポジトリ (HANDLE) PDF Web Site ほか1件をすべて表示 一部だけ表示 被引用文献4件 参考文献44件 オープンアクセス
  • Kageyama, Tatsuto
    Fac Engn, Yokohama National University Fac Engn, Inst Adv Sci, Yokohama National University
  • Seo, Jieun
    Fac Engn, Yokohama National University Fac Engn, Inst Adv Sci, Yokohama National University
  • Yan, Lei
    Fac Engn, Yokohama National University Fac Engn, Inst Adv Sci, Yokohama National University
  • Fukuda, Junji
    Fac Engn, Yokohama National University Fac Engn, Inst Adv Sci, Yokohama National University

書誌事項

公開日
2023-10-20
資源種別
journal article
権利情報
  • Creative Commons Attribution 4.0 International
DOI
  • 10.1038/s41598-023-40521-x
公開者
Nature Portfolio

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説明

Oxytocin (OXT) is a neuropeptide hormone termed "love hormone" produced and released during childbirth and lactation. It is also produced in response to skin stimulation (e.g., during hugging and massaging) and music therapy. The effects of OXT on various organs have been revealed in recent years; however, the relationship between hair follicles and OXT remains unclear. In this study, we examined the effects of OXT on dermal papilla (DP) cells that control hair growth by secreting growth/regression signals. Gene expression analysis revealed that DP signature markers were significantly upregulated in DP cells treated with OXT. In addition, we tested the hair growth-promoting effects of OXT using in vitro hair follicle organoids. OXT promoted the growth of hair peg-like sprouting by upregulating the expression of growth-promoting factors, including genes encoding vascular endothelial growth factor A (VEGFA). This study highlights the positive effects of OXT in hair follicles and may assist in the development of new treatments for alopecia.

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