{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050865408967542272.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/2433/290863"}},{"identifier":{"@type":"DOI","@value":"10.1186/s13041-024-01150-1"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/s13041-024-01150-1.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1186/s13041-024-01150-1/fulltext.html"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"Protein turnover is crucial for cell survival, and the impairment of proteostasis leads to cell death. Aging is associated with a decline in proteostasis, as the progressive accumulation of damaged proteins is a hallmark of age-related disorders such as neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). We previously discovered that the declining function of the ubiquitin-proteasome system (UPS) in motor neurons contributes to sporadic ALS pathologies, such as progressive motor neuron loss, protein accumulation, and glial activation. However, the mechanisms of UPS dysfunction-induced cell damage, such as cell death and aggregation, are not fully understood. This study used transcriptome analysis of motor neurons with UPS dysfunction and found that the expression of N-myc downstream regulated 1 (NDRG1) gets upregulated by UPS dysfunction. Additionally, the upregulation of NDRG1 induces cell death in the Neuro2a mouse neuroblastoma cell line. These results suggest that NDRG1 is a potential marker for UPS dysfunction and may play a role in neurodegeneration, such as that seen in ALS."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070865408967542402","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hoshino, Tomonori"},{"@language":"ja","@value":"星野, 友則"}]},{"@id":"https://cir.nii.ac.jp/crid/1070865408967542274","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Mukai, Atsushi"}]},{"@id":"https://cir.nii.ac.jp/crid/1070865408967542272","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Yamashita, Hirofumi"},{"@language":"ja","@value":"山下, 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Ryosuke"},{"@language":"ja","@value":"髙橋, 良輔"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"17566606"}],"prism:publicationName":[{"@language":"en","@value":"Molecular Brain"}],"dc:publisher":[{"@value":"Springer Nature"},{"@value":"BMC"}],"prism:publicationDate":"2024-10-23","prism:volume":"17"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["© The Author(s) 2024.","This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder."],"url":[{"@id":"https://link.springer.com/content/pdf/10.1186/s13041-024-01150-1.pdf"},{"@id":"https://link.springer.com/article/10.1186/s13041-024-01150-1/fulltext.html"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Amyotrophic%20lateral%20sclerosis","dc:title":"Amyotrophic lateral sclerosis"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20death","dc:title":"Cell death"},{"@id":"https://cir.nii.ac.jp/all?q=NDRG1","dc:title":"NDRG1"},{"@id":"https://cir.nii.ac.jp/all?q=Neurodegeneration","dc:title":"Neurodegeneration"},{"@id":"https://cir.nii.ac.jp/all?q=Proteasome","dc:title":"Proteasome"},{"@id":"https://cir.nii.ac.jp/all?q=Psmc4%20(Rpt3)","dc:title":"Psmc4 (Rpt3)"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Amyotrophic lateral sclerosis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Cell death"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"NDRG1"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Neurodegeneration"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Proteasome"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Psmc4 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