急性放射線腸管障害の分子機構とその制御

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  • キュウセイ ホウシャセン チョウカン ショウガイ ノ ブンシ キコウ ト ソノ セイギョ
  • Molecular mechanisms of acute radiation intestinal injury and its control

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The intestinal tract is a typical radiosensitive tissue and a risk organ in radiotherapy that limits the prescribed dose to tumors in the abdominal and pelvic regions. High-dose radiation damage to intestinal tissue induces loss of intestinal stem cells, and it is becoming clear that this process consists of two steps: a crypt cell death process regulated by p53 and an exacerbation process by inflammatory immune responses. In this review, we will outline the molecular mechanisms of each process and discuss how to effectively control acute radiation intestinal injury.

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