Auditory brainstem response to paired clicks as a candidate marker of cochlear synaptopathy in humans

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  • Fujihira, Haruna
    NTT Communication Science Laboratories Department of Informatics, Faculty of Information Science and Electrical Engineering, Kyushu University
  • Yamagishi, Shimpei
    NTT Communication Science Laboratories
  • Furukawa, Shigeto
    NTT Communication Science Laboratories Graduate School of Public Health, Shizuoka Graduate University of Public Health Speech-Language-Hearing Center, Shizuoka General Hospital
  • Kashino, Makio
    NTT Communication Science Laboratories

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Published
2024-06-15
Resource Type
journal article
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  • Creative Commons Attribution 4.0 International
  • © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.
DOI
  • 10.1016/j.clinph.2024.06.005
Publisher
Elsevier

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Objective: This study aimed to evaluate whether auditory brainstem response (ABR) using a paired-click stimulation paradigm could serve as a tool for detecting cochlear synaptopathy (CS). / Methods: The ABRs to single-clicks and paired-clicks with various inter-click intervals (ICIs) and scores for word intelligibility in degraded listening conditions were obtained from 57 adults with normal hearing. The wave I peak amplitude and root mean square values for the post-wave I response within a range delayed from the wave I peak (referred to as the RMSpost-w1) were calculated for the single- and secondclick responses. / Results: The wave I peak amplitudes did not correlate with age except for the second-click responses at an ICI of 7 ms, and the word intelligibility scores. However, we found that the RMSpost-w1 values for the second-click responses significantly decreased with increasing age. Moreover, the RMSpost-w1 values for the second-click responses at an ICI of 5 ms correlated significantly with the scores for word intelligibility in degraded listening conditions. / Conclusions: The magnitude of the post-wave I response for the second-click response could serve as a tool for detecting CS in humans. / Significance: Our findings shed new light on the analytical methods of ABR for quantifying CS.

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