Auditory brainstem response to paired clicks as a candidate marker of cochlear synaptopathy in humans

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  • 藤平, 晴奈
    NTTコミュニケーション科学基礎研究所 九州大学大学院システム情報科学研究院情報学部門
  • 山岸, 慎平
    NTTコミュニケーション科学基礎研究所
  • 古川, 茂人
    NTTコミュニケーション科学基礎研究所 静岡社会健康医学大学院大学 静岡県立総合病院きこえとことばのセンター
  • 柏野, 牧夫
    NTTコミュニケーション科学基礎研究所

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Objective: This study aimed to evaluate whether auditory brainstem response (ABR) using a paired-click stimulation paradigm could serve as a tool for detecting cochlear synaptopathy (CS). / Methods: The ABRs to single-clicks and paired-clicks with various inter-click intervals (ICIs) and scores for word intelligibility in degraded listening conditions were obtained from 57 adults with normal hearing. The wave I peak amplitude and root mean square values for the post-wave I response within a range delayed from the wave I peak (referred to as the RMSpost-w1) were calculated for the single- and secondclick responses. / Results: The wave I peak amplitudes did not correlate with age except for the second-click responses at an ICI of 7 ms, and the word intelligibility scores. However, we found that the RMSpost-w1 values for the second-click responses significantly decreased with increasing age. Moreover, the RMSpost-w1 values for the second-click responses at an ICI of 5 ms correlated significantly with the scores for word intelligibility in degraded listening conditions. / Conclusions: The magnitude of the post-wave I response for the second-click response could serve as a tool for detecting CS in humans. / Significance: Our findings shed new light on the analytical methods of ABR for quantifying CS.

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詳細情報 詳細情報について

  • CRID
    1050867344087230336
  • NII書誌ID
    AA11523403
  • ISSN
    18728952
    13882457
  • HANDLE
    2324/7347406
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB

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