{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1050869149952556544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"URI","@value":"https://kindai.repo.nii.ac.jp/records/2003782"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"034409271"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/034409271"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I034409271"}}],"resourceType":"紀要論文(departmental bulletin paper)","dc:title":[{"@language":"ja","@value":"免疫細胞の分化と活性化に対するフラボノイド代謝物の作用"},{"@language":"en","@value":"The Effects of Flavonoid Metabolites on Immune Cell Differentiation and Activation"},{"@language":"ja-Kana","@value":"メンエキ サイボウ ノ ブンカ ト カッセイカ ニ タイスル フラボノイド タイシャブツ ノ サヨウ"}],"dc:language":"ja","description":[{"type":"Abstract","notation":[{"@language":"ja","@value":"フラボノイドは植物中で合成されるポリフェノール化合物の一種であり、食物中では糖が付加された配糖体として存在する。摂取されたフラボノイド配糖体は、糖が外れたフラボノイドアグリコンに変換された後、腸管上皮で吸収され、抱合代謝を受けてフラボノイド代謝物として門脈から輸送される。フラボノイド代謝物の一部は、門脈だけでなく、小腸からリンパ系に取り込まれることが明らかになっているが、リンパ系循環経路におけるフラボノイド代謝物の生理的役割は不明である。本研究では、ケルセチンおよびアピゲニンと、ケルセチン代謝物であるケルセチン3-グルクロニド Q3GAが腸間膜リンパ節の免疫応答に与える可能性を検討した。マウス骨髄細胞由来樹状細胞の分化、および活性化に対するフラボノイド代謝物の影響を解析したところ、 ケルセチン、アピゲニン、Q3GAのいずれにおいても、活性化樹状細胞割合および活性化マーカー分子発現レベルの有意な変化はみられなかった。一方、腸間膜リンパ節T細胞活性化に対しては、リンパ液濃度に近い濃度のQ3GA存在下において、T細胞の活性化が抑制される傾向がみられた。以上により、食事由来のフラボノイドが腸管免疫応答に抑制的に作用する可能性が示唆された。"}]},{"type":"Abstract","notation":[{"@language":"en","@value":"Flavonoids are natural plant polyphenol chemicals found in many fruits and vegetables in the form of glycosides bound to sugar groups. Ingested flavonoid glycosides are converted to flavonoid aglycones by sugar removal, absorbed in the intestinal epithelium, and further metabolized to flavonoid metabolites for transport through the portal vein. We have previously shown that flavonoid metabolites are transported from the small intestine to the lymphatic system in addition to the portal pathway, however, the physiological role of flavonoid metabolites in the lymph remains unclear. In this study, we investigated the possible role of quercetin, apigenin and quercetin metabolite, quercetin 3-glucuronide Q3GA, on immune responses in mesenteric lymph nodes. The differentiation and activation of mouse bone marrow cell-derived dendritic cells were not significantly affected by quercetin, apigenin nor Q3GA. On the other hand, the activation of T-cells from mesenteric lymph nodes tended to decrease in the presence of Q3GA, at a concentration corresponding to the lymph fluid concentration. These results suggest that dietary flavonoids may have an inhibitory effect on intestinal immune responses."}]},{"type":"Other","notation":[{"@language":"ja","@value":"論文：Paper"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1070869149952556547","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"石﨑, 永頌"},{"@language":"en","@value":"Ishizaki, Nao"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"近畿大学"},{"@language":"en","@value":"Kindai University"}]},{"@id":"https://cir.nii.ac.jp/crid/1070869149952556545","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"柳, 利咲"},{"@language":"en","@value":"Yanagi, Risa"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"近畿大学"},{"@language":"en","@value":"Kindai University"}]},{"@id":"https://cir.nii.ac.jp/crid/1070869149952556544","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"室田, 佳恵子"},{"@language":"en","@value":"Murota, Kaeko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"島根大学"},{"@language":"en","@value":"Shimane University"}]},{"@id":"https://cir.nii.ac.jp/crid/1070869149952556546","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"早坂, 晴子"},{"@language":"en","@value":"Hayasaka, Haruko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"近畿大学"},{"@language":"en","@value":"Kindai University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09162054"},{"@type":"NDL_BIB_ID","@value":"000000069458"},{"@type":"ISSN","@value":"09162054"},{"@type":"LISSN","@value":"09162054"},{"@type":"NCID","@value":"AN10074306"}],"prism:publicationName":[{"@language":"ja","@value":"近畿大学理工学総合研究所研究報告"},{"@language":"en","@value":"Science and Technology: Annual Reports by Science and Technology Research Institute"}],"dc:publisher":[{"@value":"近畿大学理工学総合研究所"}],"prism:publicationDate":"2025-05-31","prism:number":"36","prism:startingPage":"11","prism:endingPage":"18"},"url":[{"@id":"https://kindai.repo.nii.ac.jp/records/2003782"},{"@id":"http://id.ndl.go.jp/bib/034409271"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I034409271"}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01272:0007000598"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I034409271"}]}