{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215819456640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbalip.2012.02.004"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1388198112000315?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1388198112000315?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22353356"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages"}],"description":[{"notation":[{"@value":"ABC transporter G1 (ABCG1) plays a pivotal role in HDL-mediated cholesterol efflux and atherogenesis. We investigated whether, and how, retinoic acid receptors (RARs) regulate ABCG1 expression in macrophages. All-trans retinoic acid (ATRA), an RAR ligand, increased ABCG1 protein levels and apoA-I/HDL-mediated cholesterol efflux from the macrophages. Both ATRA and other RAR agonists, TTNPB and Am580, increased major transcripts driven by promoter B upstream of exon 5, though minor transcripts driven by promoter A upstream of exon 1 were only increased by ATRA. The stimulatory effects of ATRA on ABCG1 expression were completely abolished in the presence of RAR/RXR antagonists but were only partially canceled in the presence of an LXR antagonist. Adenovirus with overexpressed oxysterol sulfotransferase abolished the LXR pathway, as previously reported, and ATRA-responsiveness in ABCA1/ABCG1 expressions were respectively attenuated by 38 and 22% compared to the control virus. Promoter assays revealed that ABCG1 levels were regulated more by promoter B than promoter A, and ATRA activated promoter B in a liver X receptor-responsive element (LXRE)-dependent manner. Further, LXRE-B in intron 7, but not LXRE-A in intron 5, enhanced ATRA responsiveness under overexpression of all RAR isoforms-RARα/β/γ. In contrast, the activation of promoter B by TTNPB depended on LXRE-B and RARα, but not on RARβ/γ. Finally, chromatin immunoprecipitation and gel-shift assays revealed a specific and direct repeat 4-dependent binding of RARα to LXRE-B. In conclusion, RAR ligands increase ABCA1/G1 expression and apoA-I/HDL-mediated cholesterol efflux from macrophages, and modulate ABCG1 promoter activity via LXRE-dependent mechanisms."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658820635137","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70532464"},{"@type":"NRID","@value":"1000070532464"},{"@type":"NRID","@value":"9000326651932"},{"@type":"NRID","@value":"9000257810342"},{"@type":"NRID","@value":"9000018648869"}],"foaf:name":[{"@value":"Makoto Ayaori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443988883210","@type":"Researcher","foaf:name":[{"@value":"Emi Yakushiji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443988883072","@type":"Researcher","foaf:name":[{"@value":"Masatsune Ogura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443988883073","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro 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Lipids"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2012-04","prism:volume":"1821","prism:number":"4","prism:startingPage":"561","prism:endingPage":"572"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1388198112000315?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1388198112000315?httpAccept=text/plain"}],"createdAt":"2012-02-14","modifiedAt":"2021-12-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Tetrahydronaphthalenes","dc:title":"Tetrahydronaphthalenes"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Retinoic%20Acid","dc:title":"Receptors, Retinoic Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Western","dc:title":"Blotting, Western"},{"@id":"https://cir.nii.ac.jp/all?q=Tretinoin","dc:title":"Tretinoin"},{"@id":"https://cir.nii.ac.jp/all?q=Response%20Elements","dc:title":"Response Elements"},{"@id":"https://cir.nii.ac.jp/all?q=Benzoates","dc:title":"Benzoates"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Retinoids","dc:title":"Retinoids"},{"@id":"https://cir.nii.ac.jp/all?q=Chlorocebus%20aethiops","dc:title":"Chlorocebus aethiops"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=ATP%20Binding%20Cassette%20Transporter,%20Subfamily%20G,%20Member%201","dc:title":"ATP Binding Cassette Transporter, Subfamily G, Member 1"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20X%20Receptors","dc:title":"Liver X Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Genetic","dc:title":"Models, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Biological%20Transport","dc:title":"Biological Transport"},{"@id":"https://cir.nii.ac.jp/all?q=Orphan%20Nuclear%20Receptors","dc:title":"Orphan Nuclear Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Cholesterol","dc:title":"Cholesterol"},{"@id":"https://cir.nii.ac.jp/all?q=HEK293%20Cells","dc:title":"HEK293 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Retinoid%20X%20Receptors","dc:title":"Retinoid X Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=COS%20Cells","dc:title":"COS Cells"},{"@id":"https://cir.nii.ac.jp/all?q=ATP-Binding%20Cassette%20Transporters","dc:title":"ATP-Binding Cassette Transporters"},{"@id":"https://cir.nii.ac.jp/all?q=ATP%20Binding%20Cassette%20Transporter%201","dc:title":"ATP Binding Cassette Transporter 1"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782103222272","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22136013"},{"@type":"JGN","@value":"JP22136013"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22136013/"}],"notation":[{"@language":"ja","@value":"核内受容体を介した生体システム状態変動の細胞階層における解析"},{"@language":"en","@value":"Development of specific modulators for nuclear receptors and elucidation of their 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