{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215819899136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbamem.2011.12.031"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0005273611004688?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0005273611004688?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22244842"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Regulation of connexin expression by transcription factors and epigenetic mechanisms"}],"description":[{"notation":[{"@value":"Gap junctions are specialized cell-cell junctions that directly link the cytoplasm of neighboring cells. They mediate the direct transfer of metabolites and ions from one cell to another. Discoveries of human genetic disorders due to mutations in gap junction protein (connexin [Cx]) genes and experimental data on connexin knockout mice provide direct evidence that gap junctional intercellular communication is essential for tissue functions and organ development, and that its dysfunction causes diseases. Connexin-related signaling also involves extracellular signaling (hemichannels) and non-channel intracellular signaling. Thus far, 21 human genes and 20 mouse genes for connexins have been identified. Each connexin shows tissue- or cell-type-specific expression, and most organs and many cell types express more than one connexin. Connexin expression can be regulated at many of the steps in the pathway from DNA to RNA to protein. In recent years, it has become clear that epigenetic processes are also essentially involved in connexin gene expression. In this review, we summarize recent knowledge on regulation of connexin expression by transcription factors and epigenetic mechanisms including histone modifications, DNA methylation, and microRNA. This article is part of a Special Issue entitled: The communicating junctions, roles and dysfunctions."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751138108672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30183255"},{"@type":"NRID","@value":"1000030183255"},{"@type":"NRID","@value":"9000000767273"},{"@type":"NRID","@value":"9000024442952"},{"@type":"NRID","@value":"9000021568221"},{"@type":"NRID","@value":"9000020014979"},{"@type":"NRID","@value":"9000024475502"},{"@type":"NRID","@value":"9000252795842"},{"@type":"NRID","@value":"9000398021743"},{"@type":"NRID","@value":"9000347069077"},{"@type":"NRID","@value":"9000021487147"},{"@type":"NRID","@value":"9000259849371"},{"@type":"NRID","@value":"9000398022179"},{"@type":"NRID","@value":"9000253107418"},{"@type":"NRID","@value":"9000006345798"},{"@type":"NRID","@value":"9000021347689"},{"@type":"NRID","@value":"9000398022173"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0053806"}],"foaf:name":[{"@value":"Masahito Oyamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1030301142852389120","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60439495"},{"@type":"NRID","@value":"1000060439495"},{"@type":"NRID","@value":"9000283497541"}],"foaf:name":[{"@value":"Kumiko Takebe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284918966043394","@type":"Researcher","foaf:name":[{"@value":"Yumiko Oyamada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00052736"}],"prism:publicationName":[{"@value":"Biochimica et Biophysica Acta (BBA) - Biomembranes"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-01","prism:volume":"1828","prism:number":"1","prism:startingPage":"118","prism:endingPage":"133"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/3.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0005273611004688?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0005273611004688?httpAccept=text/plain"}],"createdAt":"2012-01-05","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Transcriptional%20Activation","dc:title":"Transcriptional Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Gap%20junction","dc:title":"Gap junction"},{"@id":"https://cir.nii.ac.jp/all?q=Biophysics","dc:title":"Biophysics"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Connexin","dc:title":"Connexin"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Connexins","dc:title":"Connexins"},{"@id":"https://cir.nii.ac.jp/all?q=Hormones","dc:title":"Hormones"},{"@id":"https://cir.nii.ac.jp/all?q=Epigenetic%20regulation","dc:title":"Epigenetic regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20regulation","dc:title":"Gene regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Epigenesis,%20Genetic","dc:title":"Epigenesis, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Components","dc:title":"Gene Components"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20factor","dc:title":"Transcription factor"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782171928576","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23617021"},{"@type":"JGN","@value":"JP23617021"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23617021/"}],"notation":[{"@language":"ja","@value":"母体栄養による胎盤機能のエピジェネティック制御：ＤＯＨａＤでの疾患発生機構として"},{"@language":"en","@value":"Epigenetic regulation of placental function by maternal nutrition as a mechanism of disease in DOHaD"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050845760667525504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications."}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143526666112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Two Regulatory Elements within the Promoter Region of the Mouse Connexin 43 Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143861525504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143907103744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gap junctions, homeostasis, and injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144013667584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Gap Junction Protein Connexin31: Molecular Cloning and Expression Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144092997632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor\n            <i>Shox2</i>\n            in Sinoatrial and Pacemaking Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144204312832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional expression of connexin57 in horizontal cells of the mouse retina"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144330903936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic organization of the rat connexin40 gene: identical transcription start sites in heart and lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144361935232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Different\n            <i>TBX5</i>\n            interactions in heart and limb defined by Holt–Oram syndrome mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145705537152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional control of myocardial connexins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146482982016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional regulation of the murine promoter by cardiac factors Nkx2-5, GATA4 and Tbx5"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285704875084672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disrupted <i>SOX10</i> regulation of <i>GJC2</i> transcription causes Pelizaeus‐Merzbacher‐like disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618520594432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The T-box gene family"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618579137536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TGF‐β induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618729922944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of the Mouse Gap Junction Gene Gjb3 Is Regulated by Distinct Mechanisms in Embryonic Stem Cells and Keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619070366976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nkx2-5 Pathways and Congenital Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619171475072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"N\n                    <sup>ε</sup>\n                    -lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619424014080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619588618496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The importance of having your SOX on: role of SOX10† in the development of neural crest-derived melanocytes and glia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619655668992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in Holt–Oram Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619832822144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of Protease-Activated Receptor-1 Contributes to Melanoma Metastasis via Regulation of Connexin 43"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620114434176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of functional regulatory regions of the connexin32 gene promoter"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620297611392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T‐box genes and heart development: Putting the “T” in heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620609626752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation analyses of the connexin gene family reveal silencing of<i>GJC1</i>(Connexin45) by promoter hypermethylation in colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620810858752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of a gap junction gene: Rat connexin-32"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620827035392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of T-box gene function in the developing heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298338417310720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187530432640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092642610176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092642652416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Astroglial Connexin43 as a Potential Target for a Mood Stabiliser"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094288345856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The novel mouse\n                    <i>connexin39</i>\n                    gene is expressed in developing striated muscle fibers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094391762944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gene structure and promoter analysis of the human GJB6 gene encoding connexin30"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094463249152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Use of alternate promoters for tissue-specific expression of the gene coding for connexin32"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094906886016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of the rat connexin 43 proximal promoter in neonatal cardiomyocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095440821120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095619545088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNAs and atrial fibrillation: new fundamentals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096553711360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Isl1</i>\n            Expression at the Venous Pole Identifies a Novel Role for the Second Heart Field in Cardiac Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664783500928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Congenital Heart Diseases and Biotechnology: Connecting by Connexin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567835907968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568911725440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Up-Regulation of Gap Junction Connexin 26 Gene in Mammary and Uterine Tissues: The Role of Sp Transcription Factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570041981952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570486410624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570522126976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ini, a Small Nuclear Protein that Enhances the Response of the Connexin43 Gene to Estrogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570882801920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570961671680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p54nrb Is a Transcriptional Corepressor of the Progesterone Receptor that Modulates Transcription of the Labor-Associated Gene, Connexin 43 (Gja1)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043461283456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wnt signaling in disease and in development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043623906944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043922773632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Developmental paradigms in heart disease: insights from tinman"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043971564416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with \"zinc-binding finger\" structure."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044069896448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044811017984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046022067840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046160360320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tandem alternative splicing of zebrafish connexin45.6"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046404959744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The connexin43 gene is responsive to oestrogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046447178368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of connexin43 expression and function by prostaglandin E\n            <sub>2</sub>\n            (PGE\n            <sub>2</sub>\n            ) and parathyroid hormone (PTH) in osteoblastic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518447264256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mouse Connexin40: Gene Structure and Promoter Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518534377984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518785945216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pervasive roles of microRNAs in cardiovascular biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519194348672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Congenital Heart Disease Caused by Mutations in the Transcription Factor\n            <i>NKX2-5</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519766891264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mitogen-activated Protein Kinase Kinase 4 Deficiency in Cardiomyocytes Causes Connexin 43 Reduction and Couples Hypertrophic Signals to Ventricular Arrhythmogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520655582336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A microRNA regulatory mechanism of osteoblast differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521140350720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mouse Connexin 45: Genomic Cloning and Exon Usage"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993631902848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Specification of the Cardiac Conduction System by Transcription Factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993925244416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994313126656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Liver cell-specific transcriptional regulation of connexin32"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994598173184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Homeobox Protein\n            <i>Hop</i>\n            Functions in the Adult Cardiac Conduction System"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995585769984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Variable promoter usage and alternative splicing in five mouse connexin genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995701615104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mapping and characterization of the basal promoter of the human connexin26 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996130817664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996266356736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996314229632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996502190080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2?5 null mutants"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468346465664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Activation of the Connexin 43 Promoter by Dimers of Activator Protein-1 Transcription Factors in Myometrial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468632905728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cell type‐specific regulation of RE‐1 silencing transcription factor (REST) target genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468690173952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MIR-206 regulates connexin43 expression during skeletal muscle development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468884966016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468886010240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of proximal and distal regulatory elements of the rat connexin32 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469027717760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469556115328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unexpected Induction of the Human Connexin 43 Promoter by the Ras Signaling Pathway Is Mediated by a Novel Putative Promoter Sequence"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469628374528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of the Pacemaker Tissues of the Heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469982550400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Muscle-specific microRNA miR-206 promotes muscle differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470087752704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Patterning the Embryonic Heart: Identification of Five Mouse Iroquois Homeobox Genes in the Developing Heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470295175168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Update on Connexin Genes and their Nomenclature in Mouse and Man"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470703389952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A New Alternatively Spliced Transcript of the Mouse Connexin32 Gene Is Expressed in Embryonic Stem Cells, Oocytes, and Liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470907760640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wnt-1 regulation of connexin43 in cardiac myocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471448050048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of connexin genes in the human retina"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943429354368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of connexin43 as a functional target for Wnt signalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943612501632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944287257216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iroquois genes: genomic organization and function in vertebrate neural development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944366714624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Suppression of Connexin43 by TBX18 Undermines Cell-Cell Electrical Coupling in Postnatal Cardiomyocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944424828800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944587722368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of Connexin47 in Oligodendrocytes is Regulated by the Sox10 Transcription Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944960778752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thyroid Hormone Receptors Bind to an Element in the Connexin43 Promoter"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945167697152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parathyroid Hormone-Induced Up-Regulation of Connexin-43 Messenger Ribonucleic Acid (mRNA) Is Mediated by Sequences within Both the Promoter and the 3′Untranslated Region of the mRNA**This work was supported in part by the group Grant GR-13299 from the Medical Research Council. The Natural Science and Engineering Research Council of Canada provided research stipend funding for this work."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945279277312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945916290560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of transcripts encoding the myometrial gap junction protein, connexin-43, by estrogen and progesterone."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946435724032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Molecular Pathway Including Id2, Tbx5, and Nkx2-5 Required for Cardiac Conduction System Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418974405248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The human connexin32 gene is transcribed from two tissue-specific promoters"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418986766976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional regulation of connexin 43 expression by retinoids and carotenoids: Similarities and differences"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419167893888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Organization and regulation of the rat <i>Cx31</i> gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419239858432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419303874688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prostaglandin Promotion of Osteocyte Gap Junction Function through Transcriptional Regulation of Connexin 43 by Glycogen Synthase Kinase 3/β-Catenin Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420180555008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420509308672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421175302272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of the connexin 43 promoter in the brook trout testis: Role of the thyroid hormones and cAMP"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893699815168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Regulation of Vertebrate Cardiac Morphogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894444620800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of connexin expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894580408704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sp1 and Sp3 Activate the Rat Connexin40 Proximal Promoter"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895315969152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895687901312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Upstream genomic sequence of the human connexin26 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363101969035627136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of Astroglial Connexin Is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368239029120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368409827584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369051232768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiac Expression of the Ventricle-Specific Homeobox Gene Irx4 Is Modulated by Nkx2-5 and dHand"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370580480000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T‐targets: Clues to understanding the functions of T‐box proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844188825600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845137800576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic organization and alternative transcripts of the human Connexin40 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845211042560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Segment‐specific expression of <i>connexin31</i> in the embryonic hindbrain is regulated by <i>Krox20</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846030705536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiac Development and Implications for Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318337498880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoter activity of the rat connexin 43 gene in NRK cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318790837376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Connexin 32</i> promoter P2 mutations: A mechanism of peripheral nerve dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319520065024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Redefining the structure of the mouse connexin43 gene: selective promoter usage and alternative splicing mechanisms yield transcripts with different translational efficiencies"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319558492928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tbx2 Represses Expression of Connexin43 in Osteoblastic-like Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320193164416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320651788288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320772685952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical Role of the Transcriptional Repressor Neuron-restrictive Silencer Factor in the Specific Control of Connexin36 in Insulin-producing Cell Lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321183220608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Cx30.2</i>enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793584340864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic organization and chromosomal localization of the mouse Connexin36 (mCx36) gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793598209664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1α"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793722678016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A new exon in the 5′ untranslated region of the <i>connexin32</i> gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793818985472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793955809152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794528285312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor α Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794841916544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of the gap junction protein connexin-43 is increased in the human myometrium toward term and with the onset of labor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794923396480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TBX5 overexpression stimulates differentiation of chamber myocardium in P19C16 embryonic carcinoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795183912576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795186858240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Iroquois homeobox gene 3</i>\n            establishes fast conduction in the cardiac His–Purkinje network"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795210231296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Holt-Oram syndrome: a clinical genetic study."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795361816576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early Signals in Cardiac Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795765716096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268159314432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increase in messenger ribonucleic acid encoding the myometrial gap junction protein, connexin-43, requires protein synthesis and is associated with increased expression of the activator protein-1, c-fos."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268375279744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268734266112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sequence and Structure of the Mouse Connexin45 Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268882615040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Suberoylanilide Hydroxamic Acid Enhances Gap Junctional Intercellular Communication via Acetylation of Histone Containing <i>Connexin 43</i> Gene Locus"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269325705984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of the rat connexin40 promoter: two Sp1/Sp3 binding sites contribute to transcriptional activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269403331200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270043334400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Krox-20 controls myelination in the peripheral nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270240843264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of Protein Kinase C in Human Uterine Smooth Muscle Induces connexin-43 Gene Transcription through an AP-1 Site in the Promoter Sequence"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270623507712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The human connexin gene family of gap junction proteins: Distinct chromosomal locations but similar structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271024246144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594118915","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594119042","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gap junction genes and their regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594119169","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional redundancy and compensation among members of gap junction protein families?"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594119170","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A second alternative transcript of the gap junction gene connexin32 is expressed in murine Schwann cells and modulated in injured sciatic nerve"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594119171","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodal micrometastasis in non-small cell lung cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594119689","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594119812","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gap junctions and hemichannels in signal transmission, function and development of bone"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594120078","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elevated connexin-43 expression in term human myometrium correlates with elevated c-Jun expression and is independent of myometrial estrogen receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941594120194","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.bbamem.2011.12.031"},{"@type":"KAKEN","@value":"PRODUCT-14213093"},{"@type":"OPENAIRE","@value":"doi_dedup___::dc9bb2c392b8cf7753361150236b8688"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2022.112750_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0136952_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"},{"@type":"CROSSREF","@value":"10.3390/ijms21197019_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"},{"@type":"CROSSREF","@value":"10.3390/ijms22010339_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"},{"@type":"CROSSREF","@value":"10.4028/www.scientific.net/amr.995.85_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"},{"@type":"CROSSREF","@value":"10.1097/hjh.0000000000002845_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"},{"@type":"CROSSREF","@value":"10.3390/cells9020414_references_DOI_LtmOJB8D19amdSCAI9ac7ZvFCDG"}]}