{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215827099136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.biomaterials.2018.03.012"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0142961218301716?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0142961218301716?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"29550580"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Regeneration of diaphragm with bio-3D cellular patch"}],"description":[{"notation":[{"@value":"Neonates with congenital diaphragmatic hernia often require surgical defect closure with a patch. Alternatives to native diaphragmatic tissue are critically needed for this paediatric surgery. The clinical efficacy of mesh patches is limited by complications associated with residual foreign material and by hernia recurrence. In this study, we used a novel bio-3D printer method to generate large scaffold-free tissue patches composed of human cells. The resulting large tissue constructs had high elasticity and strength. Cellular patches were transplanted into rats with surgically created diaphragmatic defects. Rats survived for over 710 days after implantation of tissue constructs. CT confirmed complete tissue integration of the grafts during rat growth. Histology revealed regeneration of muscle structure, neovascularization, and neuronal networks within the reconstructed diaphragms. Our results demonstrate that created cellular patches are a highly safe and effective therapeutic strategy for repairing diaphragmatic defects, and thus pave the way for a clinical trial."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847868926718724","@type":"Researcher","foaf:name":[{"@value":"Xiu-Ying Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868926718722","@type":"Researcher","foaf:name":[{"@value":"Yusuke Yanagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868926718721","@type":"Researcher","foaf:name":[{"@value":"Zijing Sheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868926718725","@type":"Researcher","foaf:name":[{"@value":"Kouji Nagata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868926718720","@type":"Researcher","foaf:name":[{"@value":"Koichi Nakayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326229111424","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20197247"},{"@type":"NRID","@value":"1000020197247"},{"@type":"CINII_AUTHOR_ID","@value":"DA13042240"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA13042240#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA13042240"},{"@type":"NRID","@value":"9000014619428"},{"@type":"NRID","@value":"9000364909643"},{"@type":"NRID","@value":"9000364904756"},{"@type":"NRID","@value":"9000364867038"},{"@type":"NRID","@value":"9000242721773"},{"@type":"NRID","@value":"9000356538607"},{"@type":"NRID","@value":"9000364848119"},{"@type":"NRID","@value":"9000335562112"},{"@type":"NRID","@value":"9000381070486"},{"@type":"NRID","@value":"9000018718975"},{"@type":"NRID","@value":"9000002139123"},{"@type":"NRID","@value":"9000364878495"},{"@type":"NRID","@value":"9000364872656"},{"@type":"NRID","@value":"9000364923283"},{"@type":"NRID","@value":"9000370754913"},{"@type":"NRID","@value":"9000241556961"},{"@type":"NRID","@value":"9000364909590"},{"@type":"NRID","@value":"9000364905562"},{"@type":"NRID","@value":"9000364905580"},{"@type":"NRID","@value":"9000260215907"},{"@type":"NRID","@value":"9000258018701"},{"@type":"NRID","@value":"9000394959513"},{"@type":"NRID","@value":"9000018702443"},{"@type":"NRID","@value":"9000364922884"},{"@type":"NRID","@value":"9000364909442"},{"@type":"NRID","@value":"9000364867271"},{"@type":"NRID","@value":"9000388534334"},{"@type":"NRID","@value":"9000356583742"},{"@type":"NRID","@value":"9000364909878"},{"@type":"NRID","@value":"9000270280368"},{"@type":"NRID","@value":"9000394958861"},{"@type":"NRID","@value":"9000364878291"},{"@type":"NRID","@value":"9000404114565"},{"@type":"NRID","@value":"9000326638062"},{"@type":"NRID","@value":"9000381074588"},{"@type":"NRID","@value":"9000327928582"},{"@type":"NRID","@value":"9000401560250"},{"@type":"NRID","@value":"9000322101659"},{"@type":"NRID","@value":"9000291604604"},{"@type":"NRID","@value":"9000363212236"},{"@type":"NRID","@value":"9000394959615"},{"@type":"NRID","@value":"9000364909664"},{"@type":"NRID","@value":"9000364909456"},{"@type":"NRID","@value":"9000014618375"},{"@type":"NRID","@value":"9000364872848"},{"@type":"NRID","@value":"9000399174005"},{"@type":"NRID","@value":"9000415173879"},{"@type":"NRID","@value":"9000398615728"},{"@type":"NRID","@value":"9000364909764"},{"@type":"NRID","@value":"9000364878809"},{"@type":"NRID","@value":"9000238261151"},{"@type":"NRID","@value":"9000364909893"},{"@type":"NRID","@value":"9000364900842"},{"@type":"NRID","@value":"9000364905414"},{"@type":"NRID","@value":"9000399514081"},{"@type":"NRID","@value":"9000399334335"},{"@type":"NRID","@value":"9000006134626"},{"@type":"NRID","@value":"9000364909772"},{"@type":"NRID","@value":"9000364907092"},{"@type":"NRID","@value":"9000364904775"},{"@type":"NRID","@value":"9000364905467"},{"@type":"NRID","@value":"9000254255599"},{"@type":"NRID","@value":"9000018396076"},{"@type":"NRID","@value":"9000370738968"},{"@type":"NRID","@value":"9000364923005"},{"@type":"NRID","@value":"9000364909905"},{"@type":"NRID","@value":"9000364877029"},{"@type":"NRID","@value":"9000397964037"},{"@type":"NRID","@value":"9000364923018"},{"@type":"NRID","@value":"9000364904648"},{"@type":"NRID","@value":"9000019006401"},{"@type":"NRID","@value":"9000399362033"},{"@type":"NRID","@value":"9000261323992"},{"@type":"NRID","@value":"9000364579278"},{"@type":"NRID","@value":"9000278509143"},{"@type":"NRID","@value":"9000364846728"},{"@type":"NRID","@value":"9000364903728"},{"@type":"NRID","@value":"9000364910133"},{"@type":"NRID","@value":"9000364873589"},{"@type":"NRID","@value":"9000364908003"},{"@type":"NRID","@value":"9000364907542"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0171876"}],"foaf:name":[{"@value":"Tomoaki Taguchi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01429612"}],"prism:publicationName":[{"@value":"Biomaterials"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2018-06","prism:volume":"167","prism:startingPage":"1","prism:endingPage":"14"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0142961218301716?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0142961218301716?httpAccept=text/plain"}],"createdAt":"2018-03-09","modifiedAt":"2025-09-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Engineering","dc:title":"Tissue Engineering"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Scaffolds","dc:title":"Tissue Scaffolds"},{"@id":"https://cir.nii.ac.jp/all?q=Diaphragm","dc:title":"Diaphragm"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Inbred%20F344","dc:title":"Rats, Inbred F344"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Printing,%20Three-Dimensional","dc:title":"Printing, Three-Dimensional"},{"@id":"https://cir.nii.ac.jp/all?q=Human%20Umbilical%20Vein%20Endothelial%20Cells","dc:title":"Human Umbilical Vein Endothelial Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Regeneration","dc:title":"Regeneration"},{"@id":"https://cir.nii.ac.jp/all?q=Hernias,%20Diaphragmatic,%20Congenital","dc:title":"Hernias, Diaphragmatic, Congenital"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781860179200","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K15645"},{"@type":"JGN","@value":"JP15K15645"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15645/"}],"notation":[{"@language":"ja","@value":"ヒルシュスプルング病および類縁疾患の治療としての新腸管作成に関する研究"},{"@language":"en","@value":"The research on creation of new intestinal tract as a treatment for Hirschsprung disease and allied diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256873225344","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H02682"},{"@type":"JGN","@value":"JP16H02682"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02682/"}],"notation":[{"@language":"ja","@value":"ヒルシュスプルング病および類縁疾患における乳歯幹細胞による病因解明と新規治療開発"},{"@language":"en","@value":"Elucidation of the etiology and development of the novel therapy using stem cells from human exfoliated deciduous teeth for Hirschsprung's disease and its allied disorders"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202617341440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of diaphragmatic hernia repair using PLGA mesh–collagen sponge hybrid scaffold: an experimental study in a rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1050023936915301248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Assembly of a tumor microtissue by stacking normal and cancer spheroids on Kenzan using a bio-3D printer to monitor dynamic cancer cell invasion in the microtissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810812295680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs."},{"@value":"Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs [in English]"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142613672320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Scaffold‐Free Bio‐3D Printing Using Spheroids as “Bio‐Inks” for Tissue (Re‐)Construction and Drug Response Tests"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142796434560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Drug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172147390464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fabrication of Cardiac Constructs Using Bio-3D Printer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017287053909632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bio-3D printing iPSC-derived human chondrocytes for articular cartilage regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692460290560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Principles of the\n                    <i>Kenzan</i>\n                    Method for Robotic Cell Spheroid-Based Three-Dimensional Bioprinting\n                    <sup/>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617557972864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent advances in bioprinting technologies for engineering different cartilage-based tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617571401856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bile duct reconstruction using scaffold-free tubular constructs created by Bio-3D printer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619935410176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Satellite Cell Builds Its Nest under Notch’s Guidance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620135517056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autologous Cell Seeding in Tracheal Tissue Engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620870326784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757426171904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bioengineering of High Cell Density Tissues with Hierarchical Vascular Networks for Ex Vivo Whole Organs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864796630144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"3D Printing in Nephrology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181221076352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183435434880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo and ex vivo methods of growing a liver bud through tissue connection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092533680256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cryopreservation method for spheroids and fabrication of scaffold-free tubular constructs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093866247552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue Engineering and Regenerative Medicine Approaches to Enhance the Functional Response to Skeletal Muscle Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656151669376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Therapeutic potential of mesenchymal stem cell transplantation in a nitrofen-induced congenital diaphragmatic hernia rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658705841664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Risk Factors for the Recurrence of the Congenital Diaphragmatic Hernia—Report from the Long-Term Follow-Up Study of Japanese CDH Study Group"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568867770880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A quantitative ELISA‐based co‐culture angiogenesis and cell proliferation assay"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131419295635200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A definition of bioinks and their distinction from biomaterial inks"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043588360704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Orthotopic transplantation of a tissue engineered diaphragm in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043824960256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Congenital Diaphragmatic Hernia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045459280000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electrical stimulation systems for cardiac tissue engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994197978624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994306388096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A review of patch options in the repair of congenital diaphragm defects"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995652102144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995872872576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468901776256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Advances in musculoskeletal tissue engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469094915456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Absorbable Versus Nonabsorbable Mesh Repair of Congenital Diaphragmatic Hernias in a Growing Animal Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469732256768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469937594112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generation of co-culture spheroids as vascularisation units for bone tissue engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470890604672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bilateral congenital diaphragmatic hernia: prognostic evaluation of a large international cohort"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944521171840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945539170048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946408635008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preclinical regulatory validation of an engineered diaphragmatic tendon made with amniotic mesenchymal stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418716107648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effectiveness of diaphragmatic repair using an abdominal muscle flap in patients with recurrent congenital diaphragmatic hernia"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894555963264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895963535488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Low recurrence rate after Gore-Tex/Marlex composite patch repair for posterolateral congenital diaphragmatic hernia"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896385985280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Comparison of Collagen and PTFE Patch Repair in a Rabbit Model of Congenital Diaphragmatic Hernia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368608373120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanical forces direct stem cell behaviour in development and regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369595311104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Improvement of diaphragmatic performance through orthotopic application of decellularized extracellular matrix patch"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844776945536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diaphragmatic repair through fetal tissue engineering: a comparison between mesenchymal amniocyte– and myoblast-based constructs"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319937899264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Satellite Cells and the Muscle Stem Cell Niche"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320805030528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural and biomechanical characteristics of the diaphragmatic tendon in infancy and childhood: an initial analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269556555008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Outcomes after muscle flap vs prosthetic patch repair for large congenital diaphragmatic hernias"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270462443520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A 3D bioprinting system to produce human-scale tissue constructs with structural integrity"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031488","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In Vitro Biofabrication of Tissues and Organs"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031491","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue engineering to repair diaphragmatic defect in a rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031497","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular dynamics in the muscle satellite cell niche"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031498","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Living patches engineered from human umbilical cord derived fibroblasts and endothelial progenitor cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031621","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031624","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vitro wounding: effects of hypoxia and transforming growth factor b 1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031753","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biomechanics and modeling of skeletal soft tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031754","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endotheliar cell vascular smooth muscel co-culture assay for high throughput screening assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608031872","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Scaffold-free tubular tissues created by a Bio-3D printer undergo remodeling and endothelialization when implanted in rat aortae"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849941608032003","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A new in vitro wound model based on the co-culture of human dermal microvascular endothelial cells and human dermal fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204696559744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mitochondria Regulate the Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth"}]},{"@id":"https://cir.nii.ac.jp/crid/1390287142238567424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Study on Pipetting Motion Optimization of Automatic Spheroid Culture System for Spheroid Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390584818415020928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of Spheroid Morphology Over Time Using a Spheroid Formation System in Fusion Experiments"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.biomaterials.2018.03.012"},{"@type":"KAKEN","@value":"PRODUCT-21888476"},{"@type":"KAKEN","@value":"PRODUCT-22254908"},{"@type":"OPENAIRE","@value":"doi_dedup___::b1f2253a0449101208f78d25a4888d73"},{"@type":"CROSSREF","@value":"10.1002/adhm.201901831_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1038/s41598-020-65681-y_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.14326/abe.14.101_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1016/j.msec.2021.112005_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1016/j.reth.2021.02.001_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1002/adma.202209149_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1007/978-3-031-11570-7_9_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1007/s00595-019-01783-z_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0230428_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1088/1758-5090/ac1c99_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1007/978-1-0716-1484-6_6_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1016/j.bej.2024.109536_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.1088/1758-5090/aaec52_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"},{"@type":"CROSSREF","@value":"10.20965/jrm.2021.p0078_references_DOI_XfCRKVetfL96Yd1nNswxq2wLeBt"}]}