{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215827703680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.biopha.2016.01.005"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0753332215304376?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0753332215304376?httpAccept=text/plain"}},{"identifier":{"@type":"DOI","@value":"10.1016/j.ajpath.2016.02.014"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S000294401630030X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S000294401630030X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"27085138"}},{"identifier":{"@type":"PMID","@value":"26898435"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling enhances angiogenesis in a surgical sponge model."}],"description":[{"notation":[{"@value":"The persistence of proinflammatory macrophages, which are recruited to the granulation tissue, impairs the healing of diabetic wounds. Herein, we examined the role of vascular endothelial growth factor receptor type 1 (VEGFR1) signaling in streptozotocin (STZ)-induced diabetic wound healing. Angiogenesis, lymphangiogenesis, and the healing of full-thickness skin wounds were impaired in STZ-treated wild-type (WT) mice compared with vehicle-treated WT mice, with attenuated recruitment of VEGFR1-positive macrophages expressing vascular endothelial growth factor (VEGF)-A, VEGF-C, and VEGF-D to the wound granulation tissue. These phenomena were even more prevalent in STZ-treated VEGFR1 tyrosine kinase knockout mice (VEGFR1 TK(-/-) mice). STZ-treated WT mice, but not STZ-treated VEGFR1 TK(-/-) mice, showed accelerated wound healing when treated with placenta growth factor. Compared with that of STZ-treated WT mice, the wound granulation tissue of STZ-treated VEGFR1 TK(-/-) mice contained more VEGFR1-positive cells expressing IL-1β [a classic (M1) activated macrophage marker] and fewer VEGFR1-positive cells expressing the mannose receptor [CD206; an alternatively activated (M2) macrophage marker]. Treatment of STZ-treated VEGFR1 TK(-/-) mice with an IL-1β-neutralizing antibody restored impaired wound healing and angiogenesis/lymphangiogenesis and induced macrophages in the wound granulation tissue to switch to an M2 phenotype. Taken together, these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in STZ-induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380003443997182849","@type":"Researcher","foaf:name":[{"@value":"Keiichi Park"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182848","@type":"Researcher","foaf:name":[{"@value":"Hideki Amano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182856","@type":"Researcher","foaf:name":[{"@value":"Yoshiya Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182851","@type":"Researcher","foaf:name":[{"@value":"Shinya Kashiwagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182852","@type":"Researcher","foaf:name":[{"@value":"Yasuharu Yamazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182854","@type":"Researcher","foaf:name":[{"@value":"Akira Takeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182850","@type":"Researcher","foaf:name":[{"@value":"Masabumi Shibuya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003443997182853","@type":"Researcher","foaf:name":[{"@value":"Hidero Kitasato"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326234576896","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70181641"},{"@type":"NRID","@value":"1000070181641"},{"@type":"NRID","@value":"9000001646671"},{"@type":"NRID","@value":"9000259836007"},{"@type":"NRID","@value":"9000000400401"},{"@type":"NRID","@value":"9000283603956"},{"@type":"NRID","@value":"9000356588084"},{"@type":"NRID","@value":"9000283604056"},{"@type":"NRID","@value":"9000319068786"},{"@type":"NRID","@value":"9000021377969"},{"@type":"NRID","@value":"9000259835852"},{"@type":"NRID","@value":"9000388493730"},{"@type":"NRID","@value":"9000001824824"},{"@type":"NRID","@value":"9000020380428"},{"@type":"NRID","@value":"9000259835859"},{"@type":"NRID","@value":"9000283603863"},{"@type":"NRID","@value":"9000014197032"},{"@type":"NRID","@value":"9000020524373"},{"@type":"NRID","@value":"9000001766929"},{"@type":"NRID","@value":"9000309185816"},{"@type":"NRID","@value":"9000347361111"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/mmajima"}],"foaf:name":[{"@value":"Masataka Majima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07533322"},{"@type":"PISSN","@value":"00029440"}],"prism:publicationName":[{"@value":"Biomedicine & Pharmacotherapy"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2016-03","prism:volume":"78","prism:startingPage":"140","prism:endingPage":"149"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0753332215304376?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0753332215304376?httpAccept=text/plain"},{"@id":"https://api.elsevier.com/content/article/PII:S000294401630030X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S000294401630030X?httpAccept=text/plain"}],"createdAt":"2016-01-25","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Wound%20Healing","dc:title":"Wound Healing"},{"@id":"https://cir.nii.ac.jp/all?q=Vascular%20Endothelial%20Growth%20Factor%20Receptor-1","dc:title":"Vascular Endothelial Growth Factor Receptor-1"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-1beta","dc:title":"Interleukin-1beta"},{"@id":"https://cir.nii.ac.jp/all?q=Fluorescent%20Antibody%20Technique","dc:title":"Fluorescent Antibody Technique"},{"@id":"https://cir.nii.ac.jp/all?q=Neovascularization,%20Physiologic","dc:title":"Neovascularization, Physiologic"},{"@id":"https://cir.nii.ac.jp/all?q=Flow%20Cytometry","dc:title":"Flow Cytometry"},{"@id":"https://cir.nii.ac.jp/all?q=Real-Time%20Polymerase%20Chain%20Reaction","dc:title":"Real-Time Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Diabetes%20Mellitus,%20Experimental","dc:title":"Diabetes Mellitus, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphangiogenesis","dc:title":"Lymphangiogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781916418176","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K10581"},{"@type":"JGN","@value":"JP16K10581"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10581/"}],"notation":[{"@language":"ja","@value":"生理活性脂質を介した自然免疫細胞間クロストークによる肝修復制御"},{"@language":"en","@value":"Interaction between immune cells regulates liver repair through lipid mediators."}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782288841856","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26293055"},{"@type":"JGN","@value":"JP26293055"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293055/"}],"notation":[{"@language":"ja","@value":"病態時のリンパ管・リンパ組織の可塑性を制御する生理活性脂質の解析と治療への応用"},{"@language":"en","@value":"Roles of bioactive lipids in regulation of lymphatic plasticity"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782306635520","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26463022"},{"@type":"JGN","@value":"JP26463022"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26463022/"}],"notation":[{"@language":"ja","@value":"臨床に向けて顎骨欠損への適切な再生代替骨の選択"},{"@language":"en","@value":"The choice of the suitable regenerated substitutive bone to the defect of jaw bone"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256825717376","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K08241"},{"@type":"JGN","@value":"JP15K08241"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08241/"}],"notation":[{"@language":"ja","@value":"炎症時のリンパ管新生を増強する細胞特異的トロンボキサン受容体シグナルの解析"},{"@language":"en","@value":"Role of TP signaling in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256836041600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K15056"},{"@type":"JGN","@value":"JP15K15056"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15056/"}],"notation":[{"@language":"ja","@value":"腫瘍リンパ節転移を抑制する新治療戦略：生理活性脂質による前転移ニッチェ形成の制御"},{"@language":"en","@value":"Prostanoid regulates premetastatic niche formation in lung cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257281743360","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26462132"},{"@type":"JGN","@value":"JP26462132"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462132/"}],"notation":[{"@language":"ja","@value":"縦隔リンパ節転移巣を制御するプロスタグランジンE2-EP3シグナリングの解析"},{"@language":"en","@value":"The role of Prostanoid in premetastatic niche in regional lymph nodes."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050850646060068224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216795436160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219445971712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGFR1-Positive Macrophages Facilitate Liver Repair and Sinusoidal Reconstruction after Hepatic Ischemia/Reperfusion Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005518340946816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144421193472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145147010176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cyclo‐oxygenase‐2 enhances basic fibroblast growth factor‐induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145323461120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wound Macrophages as Key Regulators of Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145770679936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691876911232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modeling angiogenesis with micro- and nanotechnology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709741588096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Liver Repair through Restoration of Liver Microvasculature after Acetaminophen Hepatotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712585864960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620520297344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620936221184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621068411904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression and function of vascular endothelial growth factor receptors (Flt-1 and Flk-1) in vascular adventitial fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165279968128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4+ cells recruited from bone marrow"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165781104256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168681537408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles of Prostaglandin E\n            <sub>2</sub>\n            –EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168908198784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184738837888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles of receptor activity‐modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092647824640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092708126464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094557218944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095863918976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656882961536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin II Type 1A Receptor Signaling Facilitates Tumor Metastasis Formation through P-Selectin–Mediated Interaction of Tumor Cells with Platelets and Endothelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656929998208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656938087680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657257358720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RAMP1 signaling improves lymphedema and promotes lymphangiogenesis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659491930240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thromboxane A<sub>2</sub>induces blood flow recovery via platelet adhesion to ischaemic regions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659715476608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leukotriene B\n                    <sub>4</sub>\n                    type‐1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661479943680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prostanoid induces premetastatic niche in regional lymph nodes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662502878720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role of Vascular Endothelial Growth Factor Receptor-1 Signaling in the Recovery from Ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569115248512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854342736256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"VEGFR1 TK signaling protects the lungs against LPS-induced injury by suppressing the activity of alveolar macrophages and enhancing the anti-inflammatory function of monocyte-derived macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131415838146304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lymphangiogenesis and accumulation of reparative macrophages contribute to liver repair after hepatic ischemia–reperfusion injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044316965376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044839345280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blocking Interleukin-1β Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045887783552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of placental invasion of the uterus and their control"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518818082048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pro-Inflammatory Chemokine CCL2 (MCP-1) Promotes Healing in Diabetic Wounds by Restoring the Macrophage Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519229395840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519793317760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519842008320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Placenta Growth Factor in Diabetic Wound Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520121349120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520234731648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520585615616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521323819776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification and characterization of VEGF-A–responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993512589824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993930303360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The biology of VEGF and its receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993948591744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994076449280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of wound healing responses in lupus‐prone New Zealand White mouse strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468409558528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469231841024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiogenesis in cancer, vascular, rheumatoid and other disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470250341248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Topical Vascular Endothelial Growth Factor Accelerates Diabetic Wound Healing through Increased Angiogenesis and by Mobilizing and Recruiting Bone Marrow-Derived Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470593698560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470828044672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471060724864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recruitment of a Prostaglandin E Receptor Subtype, EP3-Expressing Bone Marrow Cells Is Crucial in Wound-Induced Angiogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943774911872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944538762624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945712005632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420191504128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420348104192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alternative activation of macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420625771264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage plasticity and polarization: in vivo veritas"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894149898240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894533504384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894572816896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interrelation of immunity and tissue repair or regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895184803840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895725950592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895805933056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: The role for KDR and MMP-9"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895842875392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The global burden of diabetic foot disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896075378432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impairment in Ischemia-Induced Neovascularization in Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368578214656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370947456256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGFR-1–Selective VEGF Homologue PlGF Is Arteriogenic"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371213338112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371383661568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiogenesis in cancer and other diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843621152128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel Function for Vascular Endothelial Growth Factor Receptor-1 on Epidermal Keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845409387008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845518037120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Myeloid cell dysfunction and the pathogenesis of the diabetic chronic wound"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846234694912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Ligand-Independent VEGFR2 Signaling Pathway Limits Angiogenic Responses in Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319590874496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Roles of Macrophages in Diverse Phases of Skin Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319866403456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Transgenic Mouse Model of Inducible Macrophage Depletion"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319968404480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320944824704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular Endothelial Growth Factor-C Accelerates Diabetic Wound Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793474216448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271224209280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1370851320075737606","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205103170560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Treatment With Recombinant Placental Growth Factor (PlGF) Enhances Both Angiogenesis and Arteriogenesis and Improves Survival After Myocardial Infarction"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.biopha.2016.01.005"},{"@type":"CROSSREF","@value":"10.1016/j.ajpath.2016.02.014"},{"@type":"KAKEN","@value":"PRODUCT-21240397"},{"@type":"KAKEN","@value":"PRODUCT-21029265"},{"@type":"KAKEN","@value":"PRODUCT-21029266"},{"@type":"KAKEN","@value":"PRODUCT-21092259"},{"@type":"KAKEN","@value":"PRODUCT-21180253"},{"@type":"KAKEN","@value":"PRODUCT-21103737"},{"@type":"KAKEN","@value":"PRODUCT-21103738"},{"@type":"KAKEN","@value":"PRODUCT-21088827"},{"@type":"OPENAIRE","@value":"doi_dedup___::372c35b52f127fc50e4994668000b204"},{"@type":"OPENAIRE","@value":"doi_dedup___::8baad032ab671e2bf697d89d374ab725"},{"@type":"CROSSREF","@value":"10.1038/s41374-019-0364-0_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1039/c7lc00774d_references_DOI_Y5s89ou9hJIHsDiRcJ4e5BhSuq0"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0178232_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1016/j.jss.2017.05.124_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1016/j.jphs.2020.05.003_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1016/j.biopha.2020.110264_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1002/jbm.a.36639_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1016/j.taap.2024.117083_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"},{"@type":"CROSSREF","@value":"10.1007/s10456-020-09718-w_references_DOI_QTtVu4RDr7JHoIwlB6peJF8VCCf"}]}