{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215828250112.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.biopsych.2010.12.022"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006322310013144?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006322310013144?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"21497680"}},{"identifier":{"@type":"HANDLE","@value":"20.500.14243/23867"}},{"identifier":{"@type":"HANDLE","@value":"2434/158888"}},{"identifier":{"@type":"HANDLE","@value":"10281/39759"}},{"identifier":{"@type":"HANDLE","@value":"11383/1729993"}},{"identifier":{"@type":"HANDLE","@value":"11311/636912"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism"}],"description":[{"notation":[{"@value":"Oxytocin (OT) has been suggested as a treatment to improve social behavior in autistic patients. Accordingly, the OT (Oxt(-/-)) and the OT receptor null mice (Oxtr(-/-)) display autistic-like deficits in social behavior, increased aggression, and reduced ultrasonic vocalization.Oxtr(-/-) mice were characterized for general health, sociability, social novelty, cognitive flexibility, aggression, and seizure susceptibility. Because vasopressin (AVP) and OT cooperate in controlling social behavior, learning, and aggression, they were tested for possible rescue of the impaired behaviors. Primary hyppocampal cultures from Oxtr(+/+) and Oxtr(-/-) mouse embryos were established to investigate the balance between gamma-aminobutyric acid (GABA) and glutamate synapses and the expression levels of OT and AVP (V1a) receptors were determined by autoradiography.Oxtr(-/-) mice display two additional, highly relevant, phenotypic characteristics: 1) a resistance to change in a learned pattern of behavior, comparable to restricted interests and repetitive behavior in autism, and 2) an increased susceptibility to seizures, a frequent and clinically relevant symptom of autism. We also show that intracerebral administration of both OT and AVP lowers aggression and fully reverts social and learning defects by acting on V1a receptors and that seizure susceptibility is antagonized by peripherally administered OT. Finally, we detect a decreased ratio of GABA-ergic versus total presynapses in hippocampal neurons of Oxtr(-/-) mice.Autistic-like symptoms are rescued on administration of AVP and OT to young Oxtr(-/-) adult animals. The Oxtr(-/-) mouse is thus instrumental to investigate the neurochemical and synaptic abnormalities underlying autistic-like disturbances and to test new strategies of pharmacologic intervention."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847868927850882","@type":"Researcher","foaf:name":[{"@value":"Mariaelvina Sala"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850887","@type":"Researcher","foaf:name":[{"@value":"Daniela Braida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850752","@type":"Researcher","foaf:name":[{"@value":"Daniela Lentini"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850886","@type":"Researcher","foaf:name":[{"@value":"Marta Busnelli"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850885","@type":"Researcher","foaf:name":[{"@value":"Elisabetta Bulgheroni"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850892","@type":"Researcher","foaf:name":[{"@value":"Valeria Capurro"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850884","@type":"Researcher","foaf:name":[{"@value":"Annamaria Finardi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850888","@type":"Researcher","foaf:name":[{"@value":"Andrea Donzelli"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850889","@type":"Researcher","foaf:name":[{"@value":"Linda Pattini"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850891","@type":"Researcher","foaf:name":[{"@value":"Tiziana Rubino"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850883","@type":"Researcher","foaf:name":[{"@value":"Daniela Parolaro"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801193499648","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10164609"},{"@type":"NRID","@value":"1000010164609"},{"@type":"NRID","@value":"9000283893924"},{"@type":"NRID","@value":"9000253201770"},{"@type":"NRID","@value":"9000392138120"},{"@type":"NRID","@value":"9000370732935"},{"@type":"NRID","@value":"9000004255542"},{"@type":"NRID","@value":"9000364528094"},{"@type":"NRID","@value":"9000347068240"},{"@type":"NRID","@value":"9000252878090"},{"@type":"NRID","@value":"9000006861865"},{"@type":"NRID","@value":"9000347071222"},{"@type":"NRID","@value":"9000411963394"},{"@type":"NRID","@value":"9000399166610"},{"@type":"NRID","@value":"9000347074316"},{"@type":"NRID","@value":"9000253471083"},{"@type":"NRID","@value":"9000018469876"},{"@type":"NRID","@value":"9000237947868"},{"@type":"NRID","@value":"9000304616214"},{"@type":"NRID","@value":"9000391623924"},{"@type":"NRID","@value":"9000347160954"},{"@type":"NRID","@value":"9000021825833"},{"@type":"NRID","@value":"9000364320664"},{"@type":"NRID","@value":"9000022251973"},{"@type":"NRID","@value":"9000255961748"},{"@type":"NRID","@value":"9000398559305"},{"@type":"NRID","@value":"9000283894652"},{"@type":"NRID","@value":"9000347067795"},{"@type":"NRID","@value":"9000392763515"},{"@type":"NRID","@value":"9000018525471"},{"@type":"NRID","@value":"9000409578835"},{"@type":"NRID","@value":"9000310345036"},{"@type":"NRID","@value":"9000004419288"},{"@type":"NRID","@value":"9000315143018"},{"@type":"NRID","@value":"9000253472503"},{"@type":"NRID","@value":"9000256742900"},{"@type":"NRID","@value":"9000347103969"},{"@type":"NRID","@value":"9000253202591"},{"@type":"NRID","@value":"9000238234592"},{"@type":"NRID","@value":"9000278506564"},{"@type":"NRID","@value":"9000021029764"},{"@type":"NRID","@value":"9000392069293"},{"@type":"NRID","@value":"9000256742855"},{"@type":"NRID","@value":"9000018470631"},{"@type":"NRID","@value":"9000391620570"},{"@type":"NRID","@value":"9000315680902"},{"@type":"NRID","@value":"9000253151545"},{"@type":"NRID","@value":"9000253173255"},{"@type":"NRID","@value":"9000283623190"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ishikorobisawa"}],"foaf:name":[{"@value":"Katsuhiko Nishimori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850890","@type":"Researcher","foaf:name":[{"@value":"Marco Parenti"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868927850881","@type":"Researcher","foaf:name":[{"@value":"Bice Chini"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00063223"}],"prism:publicationName":[{"@value":"Biological Psychiatry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2011-05","prism:volume":"69","prism:number":"9","prism:startingPage":"875","prism:endingPage":"882"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006322310013144?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006322310013144?httpAccept=text/plain"}],"createdAt":"2011-02-09","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=vasopressin","dc:title":"vasopressin"},{"@id":"https://cir.nii.ac.jp/all?q=autism%20spectrum%20disorders","dc:title":"autism spectrum disorders"},{"@id":"https://cir.nii.ac.jp/all?q=Oxytocin","dc:title":"Oxytocin"},{"@id":"https://cir.nii.ac.jp/all?q=Hippocampus","dc:title":"Hippocampus"},{"@id":"https://cir.nii.ac.jp/all?q=cognitive%20flexibility","dc:title":"cognitive flexibility"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cognition","dc:title":"Cognition"},{"@id":"https://cir.nii.ac.jp/all?q=Seizures","dc:title":"Seizures"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Autistic%20Disorder","dc:title":"Autistic Disorder"},{"@id":"https://cir.nii.ac.jp/all?q=Social%20Behavior","dc:title":"Social Behavior"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Animal%20model%20;%20autism%20spectrum%20disorders%20;%20cognitive%20flexibility%20;%20oxytocin%20;%20seizures%20;%20vasopressin","dc:title":"Animal model ; autism spectrum disorders ; cognitive flexibility ; oxytocin ; seizures ; vasopressin"},{"@id":"https://cir.nii.ac.jp/all?q=seizures","dc:title":"seizures"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Analysis%20of%20Variance","dc:title":"Analysis of Variance"},{"@id":"https://cir.nii.ac.jp/all?q=animal%20model","dc:title":"animal model"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Aggression","dc:title":"Aggression"},{"@id":"https://cir.nii.ac.jp/all?q=Arginine%20Vasopressin","dc:title":"Arginine Vasopressin"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Oxytocin","dc:title":"Receptors, Oxytocin"},{"@id":"https://cir.nii.ac.jp/all?q=Autoradiography","dc:title":"Autoradiography"},{"@id":"https://cir.nii.ac.jp/all?q=Aggression/*drug%20effects/physiology,%20Analysis%20of%20Variance,%20Animals,%20Arginine%20Vasopressin/metabolism,%20/*pharmacology,%20Autistic%20Disorder,%20Autoradiography,%20Cells,%20Cultured,%20Cognition/*drug%20effects/physiology,%20Disease%20Models,%20Animal%20Hippocampus/cytology/drug,%20effects/metabolism,%20Immunohistochemistry,%20Male,%20Mice,%20Mice,%20Knockout,%20Neurons/cytology/drug%20effects/metabolism,%20Oxytocin/metabolism/*pharmacology,%20Receptors,%20Oxytocin/*genetics,%20Seizures/genetics/*physiopathology,%20*Social%20Behavior","dc:title":"Aggression/*drug effects/physiology, Analysis of Variance, Animals, Arginine Vasopressin/metabolism, /*pharmacology, Autistic Disorder, Autoradiography, Cells, Cultured, Cognition/*drug effects/physiology, Disease Models, Animal Hippocampus/cytology/drug, effects/metabolism, Immunohistochemistry, Male, Mice, Mice, Knockout, Neurons/cytology/drug effects/metabolism, Oxytocin/metabolism/*pharmacology, Receptors, Oxytocin/*genetics, Seizures/genetics/*physiopathology, *Social Behavior"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782143217408","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23240057"},{"@type":"JGN","@value":"JP23240057"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23240057/"}],"notation":[{"@language":"ja","@value":"エストロゲンによる社会行動制御の神経機構"},{"@language":"en","@value":"Neural Mechanism of the Regulation of Social Behavior by Estrogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257038802816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21028002"},{"@type":"JGN","@value":"JP21028002"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21028002/"}],"notation":[{"@language":"ja","@value":"精原細胞の減数分裂と精子形成パキテン期通過に必須の核内因子Dmrt7の機能解明"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257128299136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23380055"},{"@type":"JGN","@value":"JP23380055"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380055/"}],"notation":[{"@language":"ja","@value":"オキシトシン・オキシトシン受容体系が担う新たな生理機能の探求"},{"@language":"en","@value":"Study of novel physiological function by the system with oxytocin and its receptor."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335953735296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: a case-control study in a Japanese population and functional analysis."}]},{"@id":"https://cir.nii.ac.jp/crid/1050001335992296320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD38 and its role in oxytocin secretion and social behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282677707944448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760922426368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Social memory, amnesia, and autism: Brain oxytocin secretion is regulated by NAD + metabolites and single nucleotide polymorphisms of CD38"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005516671691392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relay of peripheral oxytocin to central oxytocin neurons via vagal afferents for regulating feeding"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142848685952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Detection of neuropeptides in vivo and open questions for current and upcoming fluorescent sensors for neuropeptides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144061465600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promoting social behavior with oxytocin in high-functioning autism spectrum disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391877441408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708421727232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711954136448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxytocin receptor signaling contributes to olfactory avoidance behavior induced by an unpleasant odorant"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285715519519360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286992338823424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619503561856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620617504128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The savant syndrome: an extraordinary condition. A synopsis: past, present, future"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620890123264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Peptide That Binds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182342853248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183441998464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185737471616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of oxytocin in the control of stress and food intake"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092366969088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cesarean section delivery is a risk factor of autism-related behaviors in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094850204032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096117800832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin, vasopressin, and autism: is there a connection?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230607589504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Repeated exposure to kairomone-containing coffee odor improves abnormal olfactory behaviors in heterozygous oxytocin receptor knock-in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641131500416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643128806016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mice Heterozygous for the Oxytocin Receptor Gene (<i>Oxtr</i><sup><i>+/−</i></sup>) Show Impaired Social Behaviour but not Increased Aggression or Cognitive Inflexibility: Evidence of a Selective Haploinsufficiency Gene Effect"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657490700416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664411712512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Social Interaction Improved by Oxytocin in the Subclass of Autism with Comorbid Intellectual Disabilities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593753460480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of Oxytocin in Stress Responses, Allostasis and Resilience"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044940379136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A radioiodinated linear vasopressin antagonist: A ligand with high affinity and specificity for V<sub>1a</sub> receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045966159744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519401867136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD38 is critical for social behaviour by regulating oxytocin secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519722814976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993843300864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The establishment of polarity by hippocampal neurons in culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995214541568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epilepsy in autism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995421128448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"General Introduction to Vasopressin and Oxytocin: Structure⧸Metabolism, Evolutionary Aspects, Neural Pathway⧸Receptor Distribution, and Functional Aspects Relevant to Memory Processing"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995562920960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Localization and characterization of vasopressin binding sites in the rat brain using an iodinated linear AVP antagonist"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996499855360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Neurobiological Bases for Development of Pharmacological Treatments of Aggressive Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975842199076224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470514244480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470747209856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An electron microscopic study of the development of axons and dendrites by hippocampal neurons in culture. II. Synaptic relationships"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471403474560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943575398016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A role for central vasopressin in pair bonding in monogamous prairie voles"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943946479104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuroendocrinology of social information processing in rats and mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943956413184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neural circuits subserving behavioral flexibility and their relevance to schizophrenia"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945838725376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420393608320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894093912320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interactions of angiotensin IV and oxytocin on behaviour in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894604929024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synaptogenesis of hippocampal neurons in primary cell culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894768708608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autism and epilepsy: Cause, consequence, comorbidity, or coincidence?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894881737344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin Increases Retention of Social Cognition in Autism"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895660384896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aggression and the Three Opioid Families (Endorphins, Enkephalins, and Dynorphins) in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895882001536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Improved Reversal Learning and Working Memory and Enhanced Reactivity to Novelty in Mice with Enhanced GABAergic Innervation in the Dentate Gyrus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368954761344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370221538176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Postnatal Neurodevelopmental Disorders: Meeting at the Synapse?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370752315648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843433732480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843864666368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vasopressin receptor blockade in the anterior hypothalamus suppresses aggression in hamsters"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844477459584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844793502848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of mutant β2 nicotinic receptors during development is crucial for epileptogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845068615680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845732806016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318689821312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319151805824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glial modulation of synaptic transmission: Insights from the supraoptic nucleus of the hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319558481280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anatomy and neurochemistry of the pair bond"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320411476608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Social amnesia in mice lacking the oxytocin gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320928365184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Culturing hippocampal neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320931280256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autism spectrum disorders: developmental disconnection syndromes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793443292288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autism and Brain Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794434394624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795670968064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of neonatal handling on social memory, social interaction, and number of oxytocin and vasopressin neurons in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796031668480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin and Vasopressin (V1a) Receptors: Gender Differences"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796191641216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Designing mouse behavioral tasks relevant to autistic‐like behaviors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796196689792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin, Vasopressin, and the Neurogenetics of Sociality"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268471230976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of GABAergic neurons in hippocampal cell cultures"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268795727360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269769970304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polarization of caveolins and caveolae during migration of immortalized neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270491997824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The V1a Vasopressin Receptor Is Necessary and Sufficient for Normal Social Recognition: A Gene Replacement Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271091844864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Convulsing toward the pathophysiology of autism"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694366540512005","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin: The great facilitator of life"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694366540512257","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vasopressin and oxytocin receptors in the rat brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204438128000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Noxious or Non-noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549198963840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.biopsych.2010.12.022"},{"@type":"KAKEN","@value":"PRODUCT-13793246"},{"@type":"KAKEN","@value":"PRODUCT-12495945"},{"@type":"KAKEN","@value":"PRODUCT-13930468"},{"@type":"KAKEN","@value":"PRODUCT-13930478"},{"@type":"OPENAIRE","@value":"doi_dedup___::7f77ddb5d8204ab9bb393e1c0ee31229"},{"@type":"CROSSREF","@value":"10.1186/2040-2392-4-22_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2020.170456_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.3390/ijms23147550_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1038/npp.2016.283_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1242/bio.029140_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.7554/elife.22466_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.neubiorev.2016.03.013_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2018.10.011_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1038/s41598-018-32042-9_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1111/jne.12700_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2019.09.039_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2017.09.013_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2011.12.011_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1038/s41598-021-88437-8_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.3389/fnbeh.2022.983421_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1111/j.1365-2826.2012.02385.x_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.3390/diseases7010024_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.3390/ijms23010150_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2020.104695_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2019.06.007_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.4036/iis.2015.b.03_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"},{"@type":"CROSSREF","@value":"10.1016/j.neuint.2012.01.030_references_DOI_4Y4TGur4Rzsz86BoJv5KNiDPDp8"}]}