{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215835885440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bpj.2011.05.008"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006349511005789?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006349511005789?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"21723829"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Torque Generation in F1-ATPase Devoid of the Entire Amino-Terminal Helix of the Rotor That Fills Half of the Stator Orifice"}],"description":[{"notation":[{"@value":"F(1)-ATPase is an ATP-driven rotary molecular motor in which the central γ-subunit rotates inside a cylinder made of α(3)β(3) subunits. The amino and carboxyl termini of the γ rotor form a coiled coil of α-helices that penetrates the stator cylinder to serve as an axle. Crystal structures indicate that the axle is supported by the stator at two positions, at the orifice and by the hydrophobic sleeve surrounding the axle tip. The sleeve contacts are almost exclusively to the longer carboxyl-terminal helix, whereas nearly half the orifice contacts are to the amino-terminal helix. Here, we truncated the amino-terminal helix stepwise up to 50 residues, removing one half of the axle all the way up and far beyond the orifice. The half-sliced axle still rotated with an unloaded speed a quarter of the wild-type speed, with torque nearly half the wild-type torque. The truncations were made in a construct where the rotor tip was connected to a β-subunit via a short peptide linker. Linking alone did not change the rotational characteristics significantly. These and previous results show that nearly half the normal torque is generated if rotor-stator interactions either at the orifice or at the sleeve are preserved, suggesting that the make of the motor is quite robust."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847868935438213","@type":"Researcher","foaf:name":[{"@value":"Ayako Kohori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868935438209","@type":"Researcher","foaf:name":[{"@value":"Ryohei Chiwata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868935438215","@type":"Researcher","foaf:name":[{"@value":"Mohammad Delawar Hossain"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326222765952","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60392875"},{"@type":"NRID","@value":"1000060392875"},{"@type":"NRID","@value":"9000002736402"},{"@type":"NRID","@value":"9000331911149"},{"@type":"NRID","@value":"9000402477232"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0102300"}],"foaf:name":[{"@value":"Shou Furuike"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868935438212","@type":"Researcher","foaf:name":[{"@value":"Katsuyuki Shiroguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868935438208","@type":"Researcher","foaf:name":[{"@value":"Kengo Adachi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868935438210","@type":"Researcher","foaf:name":[{"@value":"Masasuke Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868935438214","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Kinosita"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00063495"}],"prism:publicationName":[{"@value":"Biophysical Journal"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2011-07","prism:volume":"101","prism:number":"1","prism:startingPage":"188","prism:endingPage":"195"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/3.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006349511005789?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006349511005789?httpAccept=text/plain"}],"createdAt":"2011-07-06","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Molecular","dc:title":"Models, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Rotation","dc:title":"Rotation"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrolysis","dc:title":"Hydrolysis"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Biophysics","dc:title":"Biophysics"},{"@id":"https://cir.nii.ac.jp/all?q=Reproducibility%20of%20Results","dc:title":"Reproducibility of Results"},{"@id":"https://cir.nii.ac.jp/all?q=Microspheres","dc:title":"Microspheres"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Structure,%20Secondary","dc:title":"Protein Structure, Secondary"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Subunits","dc:title":"Protein Subunits"},{"@id":"https://cir.nii.ac.jp/all?q=Proton-Translocating%20ATPases","dc:title":"Proton-Translocating ATPases"},{"@id":"https://cir.nii.ac.jp/all?q=Adenosine%20Triphosphate","dc:title":"Adenosine Triphosphate"},{"@id":"https://cir.nii.ac.jp/all?q=Torque","dc:title":"Torque"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cattle","dc:title":"Cattle"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophoresis,%20Polyacrylamide%20Gel","dc:title":"Electrophoresis, Polyacrylamide Gel"},{"@id":"https://cir.nii.ac.jp/all?q=Mutant%20Proteins","dc:title":"Mutant Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Sequence","dc:title":"Amino Acid Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Gold","dc:title":"Gold"},{"@id":"https://cir.nii.ac.jp/all?q=Particle%20Size","dc:title":"Particle Size"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782135455104","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22770156"},{"@type":"JGN","@value":"JP22770156"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770156/"}],"notation":[{"@language":"ja","@value":"生体分子モーターの触媒部位における構造変化モニター"},{"@language":"en","@value":"Detection of the conformational changes at a catalytic site of molecular motor"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782163908096","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23570199"},{"@type":"JGN","@value":"JP23570199"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23570199/"}],"notation":[{"@language":"ja","@value":"回転分子モーターＦ１（／Ｖ１）－ＡＴＰａｓｅの回転子を人工的に作る"},{"@language":"en","@value":"Constructing artificial rotors for rotary molecular motor F1(V1)-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257038292992","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21000011"},{"@type":"JGN","@value":"JP21000011"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21000011/"}],"notation":[{"@language":"ja","@value":"一分子生理学を超えて：生体分子機械を力で優しく働かせる"},{"@language":"en","@value":"Beyond single-molecule physiology : Letting molecular machines work by soft force"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257073044352","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21770176"},{"@type":"JGN","@value":"JP21770176"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770176/"}],"notation":[{"@language":"ja","@value":"F1-ATPaseの回転に必要不可欠な回転子領域の決定"},{"@language":"en","@value":"Ascertaining the indispensable rotor region for the rotation of F1-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257118582272","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23118717"},{"@type":"JGN","@value":"JP23118717"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23118717/"}],"notation":[{"@language":"ja","@value":"ＡＴＰ駆動の回転分子モーターを用いたＡＴＰ加水分解の１分子熱力学"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230142356352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Operation mechanism of F<sub>o</sub>F<sub>1</sub>‐adenosine triphosphate synthase revealed by its structure and dynamics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232021601024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deciphering Intrinsic Inter-subunit Couplings that Lead to Sequential Hydrolysis of F 1 -ATPase 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Synthase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298341429726464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Direct Observation of Archaellar Motor Rotation by Single-Molecular Imaging Techniques"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905626579712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dimeric assembly of F\n            <sub>1</sub>\n            -like ATPase for the gliding motility of\n            <i>Mycoplasma</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183931661440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Torque Generation and Utilization in Motor Enzyme F0F1-ATP 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article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rotary catalysis of the stator ring of F1-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640766765440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"None of the Rotor Residues of F1-ATPase Are Essential for Torque Generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658911406720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Robustness of the Rotary Catalysis Mechanism of F1-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568844201216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deletion of seven amino acid residues from the γ subunit of Escherichia coli H+-ATPase causes total loss of F1 assembly on membranes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571505004032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The γ-subunit rotation and torque generation in F\n            <sub>1</sub>\n            -ATPase from wild-type or uncoupled mutant\n            <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044246688256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stimulation of F1-ATPase activity by sodium dodecyl sulfate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046264637952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Temperature Dependence of the Rotation and Hydrolysis Activities of F1-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520086819072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The structure of the central stalk in bovine F1-ATPase at 2.4 Å resolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521524849408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"N‐terminal deletion of the γ subunit affects the stabilization and activity of chloroplast ATP synthase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993415913088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994009653376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Met23Lys mutation in subunit gamma of FOF1-ATP synthase from Rhodobacter capsulatus impairs the activation of ATP hydrolysis by protonmotive force"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468672148864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The α3β3γ Subcomplex of the F1-ATPase from the Thermophilic Bacillus PS3 with the βT165S Substitution Does Not Entrap Inhibitory MgADP in a Catalytic Site during Turnover"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946341853184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"One Rotary Mechanism for F1-ATPase over ATP Concentrations from Millimolar down to Nanomolar"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418517525120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viscoelastic Dynamics of Actin Filaments Coupled to Rotary F-ATPase: Angular Torque Profile of the Enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893792727680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A rotary molecular motor that can work at near 100% efficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893987643008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rotation of F<sub>1</sub>-ATPase: How an ATP-Driven Molecular Machine May 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cell"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844259184640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Rotor Tip Inside a Bearing of a Thermophilic F1-ATPase Is Dispensable for Torque Generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844930170112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of γ-Subunit N- and C-Termini in Assembly of the Mitochondrial ATP Synthase in Yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319872256640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pause and rotation of F\n            <sub>1</sub>\n            -ATPase during catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320329735808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Axle-Less F\n            <sub>1</sub>\n            -ATPase Rotates in the Correct Direction"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795908380928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268327012864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[11] Single-molecule imaging of rotation of F1-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269328279040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270242190848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"F0F1-ATPase gamma subunit mutations perturb the coupling between catalysis and transport."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270508678272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Torque 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