{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215853028992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.cellsig.2017.10.019"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0898656817302826?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0898656817302826?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"29102771"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR-424/503 in vitro"}],"description":[{"notation":[{"@value":"Pulmonary arterial hypertension (PAH) has a major effect on life expectancy with functional degeneracy of the lungs and right heart. Interleukin-13 (IL-13), one of the type 2 cytokines mainly associated with allergic diseases, has recently been reported to be associated with Schistosomiasis-associated PAH which shares pathological features with other forms of PAH, such as idiopathic PAH and connective tissue disease-associated PAH. But a direct pathological role of IL-13 in the development of PAH has not been explored. We examined the effects of recombinant human IL-13 on the function of primary human pulmonary artery endothelial cells (HPAECs) to examine how IL-13 influences exacerbation of PAH. IL-13 increased the expression of Rictor, which is a key molecule of mammalian target of rapamycin complex 2. Treatment of IL-13 induced HPAEC migration via Rictor. Rictor was directly regulated by both miR-424 and 503 (miR-424/503). Therefore, IL-13 increases Rictor level by regulating miR-424/503, causing the increase of HPAEC migration. Since enhancement of HPAEC migration in the lung is thought to be associated with PAH, these data suggest that IL-13 takes some roles in exacerbating PAH."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380003444022751104","@type":"Researcher","foaf:name":[{"@value":"Koichi Takagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751106","@type":"Researcher","foaf:name":[{"@value":"Munekazu Yamakuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751109","@type":"Researcher","foaf:name":[{"@value":"Takahiro Matsuyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751111","@type":"Researcher","foaf:name":[{"@value":"Kiyotaka Kondo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751108","@type":"Researcher","foaf:name":[{"@value":"Akifumi Uchida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751110","@type":"Researcher","foaf:name":[{"@value":"Shunsuke Misono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751107","@type":"Researcher","foaf:name":[{"@value":"Teruto Hashiguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444022751105","@type":"Researcher","foaf:name":[{"@value":"Hiromasa Inoue"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08986568"}],"prism:publicationName":[{"@value":"Cellular Signalling"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2018-01","prism:volume":"42","prism:startingPage":"270","prism:endingPage":"280"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0898656817302826?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0898656817302826?httpAccept=text/plain"}],"createdAt":"2017-11-02","modifiedAt":"2018-08-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Epithelial-Mesenchymal%20Transition","dc:title":"Epithelial-Mesenchymal 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