{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215860977408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.chom.2012.06.009"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1931312812002363?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1931312812002363?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"22901534"}},{"identifier":{"@type":"HANDLE","@value":"1887/106480"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex"}],"description":[{"notation":[{"@value":"The RIG-I/Mda5 sensors recognize viral intracellular RNA and trigger host antiviral responses. RIG-I signals through the adaptor protein MAVS, which engages various TRAF family members and results in type I interferon (IFNs) and proinflammatory cytokine production via activation of IRFs and NF-κB, respectively. Both the IRF and NF-κB pathways also require the adaptor protein NEMO. We determined that the RIG-I pathway is differentially regulated by the linear ubiquitin assembly complex (LUBAC), which consists of the E3 ligases HOIL-1L, HOIP, and the accessory protein SHARPIN. LUBAC downregulated virus-mediated IFN induction by targeting NEMO for linear ubiquitination. Linear ubiquitinated NEMO associated with TRAF3 and disrupted the MAVS-TRAF3 complex, which inhibited IFN activation while stimulating NF-κB-dependent signaling. In SHARPIN-deficient MEFs, vesicular stomatitis virus replication was decreased due to increased IFN production. Linear ubiquitination thus switches NEMO from a positive to a negative regulator of RIG-I signaling, resulting in an attenuated IFN response."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566393984272514","@type":"Researcher","foaf:name":[{"@value":"S. Mehdi Belgnaoui"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272384","@type":"Researcher","foaf:name":[{"@value":"Suzanne Paz"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272516","@type":"Researcher","foaf:name":[{"@value":"Sara Samuel"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272387","@type":"Researcher","foaf:name":[{"@value":"Marie-Line Goulet"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272385","@type":"Researcher","foaf:name":[{"@value":"Qiang Sun"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272386","@type":"Researcher","foaf:name":[{"@value":"Marjolein 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Iwai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272515","@type":"Researcher","foaf:name":[{"@value":"Ivan Dikic"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272512","@type":"Researcher","foaf:name":[{"@value":"John Hiscott"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566393984272513","@type":"Researcher","foaf:name":[{"@value":"Rongtuan Lin"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19313128"}],"prism:publicationName":[{"@value":"Cell Host & Microbe"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2012-08","prism:volume":"12","prism:number":"2","prism:startingPage":"211","prism:endingPage":"222"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1931312812002363?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1931312812002363?httpAccept=text/plain"}],"createdAt":"2012-08-15","modifiedAt":"2025-10-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=RNA%20viruses","dc:title":"RNA viruses"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Cancer%20Research","dc:title":"Cancer Research"},{"@id":"https://cir.nii.ac.jp/all?q=TNF%20Receptor-Associated%20Factor%203","dc:title":"TNF Receptor-Associated Factor 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