{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215870242944.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.coi.2014.08.003"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0952791514001046?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0952791514001046?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"25190609"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Homeostatic inflammation in innate immunity"}],"description":[{"notation":[{"@value":"Innate immune sensors respond not only to microbial products but also to endogenous metabolites such as nucleic acids (NAs) and lipids. Toll-like receptors (TLRs) deliver a signal from the plasma membrane and also from endolysosomes, where NAs and lipids are catabolized. Interaction of TLRs with metabolites in endolysosomes leads to homeostatic TLR activation. Dendritic cells expressing NA-sensing TLRs are steadily activated by metabolites derived from the host or commensals and produce type I IFNs, thereby provoking various types of inflammatory conditions. Here, we discuss how homeostatic inflammation is induced by innate immune sensors and is involved in maintaining immune homeostasis and causing non-infectious inflammatory diseases."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380003444040228481","@type":"Researcher","foaf:name":[{"@value":"Kensuke Miyake"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801199165952","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60224325"},{"@type":"NRID","@value":"1000060224325"},{"@type":"NRID","@value":"9000006222568"},{"@type":"NRID","@value":"9000003761947"},{"@type":"NRID","@value":"9000000374609"},{"@type":"NRID","@value":"9000018387541"},{"@type":"NRID","@value":"9000329440131"},{"@type":"NRID","@value":"9000238863474"},{"@type":"NRID","@value":"9000018470594"},{"@type":"NRID","@value":"9000241125672"},{"@type":"NRID","@value":"9000359873837"},{"@type":"NRID","@value":"9000394964338"},{"@type":"NRID","@value":"9000016430005"},{"@type":"NRID","@value":"9000336380186"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tkaisho"}],"foaf:name":[{"@value":"Tsuneyasu Kaisho"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09527915"}],"prism:publicationName":[{"@value":"Current Opinion in Immunology"}],"dc:publisher":[{"@value":"Elsevier 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Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Immunity,%20Innate","dc:title":"Immunity, Innate"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782063374208","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21117003"},{"@type":"JGN","@value":"JP21117003"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21117003/"}],"notation":[{"@language":"ja","@value":"内因性リガンドに対する樹状細胞応答機構の解明"},{"@language":"en","@value":"Mechanisms for dendritic cell responses against host-derived molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257265683328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26293106"},{"@type":"JGN","@value":"JP26293106"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293106/"}],"notation":[{"@language":"ja","@value":"樹状細胞による腸管免疫制御機構の解明"},{"@language":"en","@value":"Clarification of the intestinal immune regulatory mechanisms by dendritic 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