{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002215924314752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.febslet.2014.04.020"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2014.04.020"}},{"identifier":{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2014.04.020"}},{"identifier":{"@type":"PMID","@value":"24768995"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Tumour‐suppressive <i>microRNA‐224</i> inhibits cancer cell migration and invasion via targeting oncogenic <i>TPD52</i> in prostate cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that <jats:italic>microRNA‐224</jats:italic> (<jats:italic>miR‐224</jats:italic>) is significantly downregulated in PCa tissues. Here, we found that restoration of <jats:italic>miR‐224</jats:italic> significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic <jats:italic>TPD52</jats:italic> is a direct target of <jats:italic>miR‐224</jats:italic> regulation. Silencing of the <jats:italic>TPD52</jats:italic> gene significantly inhibits cancer cell migration and invasion. Moreover, <jats:italic>TPD52</jats:italic> expression is upregulated in cancer tissues and negatively correlates with <jats:italic>miR‐224</jats:italic> expression. We conclude that loss of tumour‐suppressive <jats:italic>miR‐224</jats:italic> enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic <jats:italic>TPD52</jats:italic>.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847869025215233","@type":"Researcher","foaf:name":[{"@value":"Yusuke Goto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215237","@type":"Researcher","foaf:name":[{"@value":"Rika Nishikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215239","@type":"Researcher","foaf:name":[{"@value":"Satoko Kojima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215240","@type":"Researcher","foaf:name":[{"@value":"Takeshi Chiyomaru"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215234","@type":"Researcher","foaf:name":[{"@value":"Hideki Enokida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215360","@type":"Researcher","foaf:name":[{"@value":"Satoru Inoguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215241","@type":"Researcher","foaf:name":[{"@value":"Takashi Kinoshita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215232","@type":"Researcher","foaf:name":[{"@value":"Miki Fuse"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658587003904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70422235"},{"@type":"NRID","@value":"1000070422235"},{"@type":"NRID","@value":"9000415049060"}],"foaf:name":[{"@value":"Shinichi Sakamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215362","@type":"Researcher","foaf:name":[{"@value":"Masayuki Nakagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215236","@type":"Researcher","foaf:name":[{"@value":"Yukio Naya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847869025215235","@type":"Researcher","foaf:name":[{"@value":"Tomohiko Ichikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751162770560","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50345013"},{"@type":"NRID","@value":"1000050345013"},{"@type":"NRID","@value":"9000002890570"},{"@type":"NRID","@value":"9000263060019"},{"@type":"NRID","@value":"9000364819644"},{"@type":"NRID","@value":"9000364808577"},{"@type":"NRID","@value":"9000006079693"},{"@type":"NRID","@value":"9000006079172"},{"@type":"NRID","@value":"9000340450801"},{"@type":"NRID","@value":"9000005807076"},{"@type":"NRID","@value":"9000007879306"},{"@type":"NRID","@value":"9000340450707"},{"@type":"NRID","@value":"9000003112052"},{"@type":"NRID","@value":"9000002702597"},{"@type":"NRID","@value":"9000000519107"},{"@type":"NRID","@value":"9000364808569"},{"@type":"NRID","@value":"9000005786680"},{"@type":"NRID","@value":"9000009560105"},{"@type":"NRID","@value":"9000340450966"},{"@type":"NRID","@value":"9000001804025"},{"@type":"NRID","@value":"9000314377469"},{"@type":"NRID","@value":"9000412626530"},{"@type":"NRID","@value":"9000237595194"},{"@type":"NRID","@value":"9000018367701"},{"@type":"NRID","@value":"9000364817751"},{"@type":"NRID","@value":"9000001443135"},{"@type":"NRID","@value":"9000364817742"},{"@type":"NRID","@value":"9000367416721"},{"@type":"NRID","@value":"9000401702502"},{"@type":"NRID","@value":"9000240537331"},{"@type":"NRID","@value":"9000345250813"},{"@type":"NRID","@value":"9000340450925"},{"@type":"NRID","@value":"9000346987372"},{"@type":"NRID","@value":"9000009559848"},{"@type":"NRID","@value":"9000003816748"},{"@type":"NRID","@value":"9000254839875"},{"@type":"NRID","@value":"9000338426139"},{"@type":"NRID","@value":"9000396142686"},{"@type":"NRID","@value":"9000340450788"},{"@type":"NRID","@value":"9000107388239"},{"@type":"NRID","@value":"9000021075534"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/F-Genome-miRNA-1127"}],"foaf:name":[{"@value":"Naohiko Seki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00145793"},{"@type":"EISSN","@value":"18733468"}],"prism:publicationName":[{"@value":"FEBS Letters"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2014-04-24","prism:volume":"588","prism:number":"10","prism:startingPage":"1973","prism:endingPage":"1982"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2014.04.020"},{"@id":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2014.04.020"}],"createdAt":"2014-04-24","modifiedAt":"2023-09-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Western","dc:title":"Blotting, Western"},{"@id":"https://cir.nii.ac.jp/all?q=TPD52","dc:title":"TPD52"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Movement","dc:title":"Cell Movement"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Tumor%20Suppressor","dc:title":"Genes, Tumor Suppressor"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Invasiveness","dc:title":"Neoplasm Invasiveness"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Prostate%20cancer","dc:title":"Prostate cancer"},{"@id":"https://cir.nii.ac.jp/all?q=microRNA","dc:title":"microRNA"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Prostatic%20Neoplasms","dc:title":"Prostatic Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=miR-224","dc:title":"miR-224"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Proteins","dc:title":"Neoplasm Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=MicroRNAs","dc:title":"MicroRNAs"},{"@id":"https://cir.nii.ac.jp/all?q=RNA%20Interference","dc:title":"RNA Interference"},{"@id":"https://cir.nii.ac.jp/all?q=Tumour%20suppressor","dc:title":"Tumour suppressor"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782231295488","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24791636"},{"@type":"JGN","@value":"JP24791636"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791636/"}],"notation":[{"@language":"ja","@value":"癌抑制マイクロＲＮＡ‐１４５が制御する前立腺癌における新規分子ネットワークの解明"},{"@language":"en","@value":"Tumor-suppressive microRNA-145 regulates molecular pathways based on microRNA expression signature in prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782246286208","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25293333"},{"@type":"JGN","@value":"JP25293333"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293333/"}],"notation":[{"@language":"ja","@value":"去勢抵抗性前立腺癌における機能性RNAネットワークの解明と革新的診断治療シーズ"},{"@language":"en","@value":"Clarification of microRNA functional networks and development of novel tools for diagnosis and treatment of castration-resistant prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782305563904","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26462430"},{"@type":"JGN","@value":"JP26462430"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462430/"}],"notation":[{"@language":"ja","@value":"去勢抵抗性前立腺癌における機能性RNAのネットワーク解析および標的分子経路の探索"},{"@language":"en","@value":"Analysis of functional RNA networks and investigation of their target genes in castration-resistant prostate cancer (CRPC)."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002220792305408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232147592576","@type":"Article","resourceType":"学術雑誌論文(journal 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cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617909472512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620692752000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620969556352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"miR‐224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757178607744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>MiR‐15b‐5p</i> inhibits castration‐resistant growth of prostate cancer cells by targeting the muscarinic cholinergic receptor <scp>CHRM3</scp>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865540567552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166739811200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166739833088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170745689344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183350326144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183364416768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aberrantly expressed microRNAs in bladder cancer and renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185485550720","@type":"Article","resourceType":"学術雑誌論文(journal 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 </i>\n                    inhibits cancer cell migration and invasion by targeting\n                    <i>\n                      <scp>ITGA</scp>\n                      3/\n                      <scp>ITGB</scp>\n                      1\n                    </i>\n                    signaling in prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664619967488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567864088704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Most mammalian mRNAs are conserved targets of microRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568430259456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression, Amplification, and Androgen Regulation of TPD52 in Prostate Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568490768000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TPD52 represents a survival factor in<i>ERBB2</i>‐amplified breast cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569140325888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570500628224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519013513600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing\n                    <i>PHLPP1</i>\n                    and\n                    <i>PHLPP2</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519605074048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Correction: Bone metastasis in prostate cancer: emerging therapeutic strategies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519786168448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Origins and Mechanisms of miRNAs and siRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995109077504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468767348736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High‐resolution array comparative genomic hybridization of 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