{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002216005662592.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.jdermsci.2014.07.010"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0923181114001832?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0923181114001832?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"25190363"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The panoply of αβT cells in the skin"}],"description":[{"notation":[{"@value":"Skin protects body from continual attack by microbial pathogens and environmental factors. Such barrier function of skin is achieved by multiple components including immune system, which is mainly regulated by lymphocytes. T lymphocytes (T cells) that express T cell receptor (TCR) α and β chains (αβT cells) control the strength and the type of immune response. CD4T cell population consists of helper T (Th) cell-subsets and immunosuppressive regulatory T (Treg) cells. Th1 cells produce IFN-γ and protect against intracellular pathogens. Th2 cells produce IL-4 family cytokines and participate in allergic skin diseases, including atopic dermatitis (AD). Th17 cells secrete IL-17, recruit granulocytes to fight against extracellular microorganisms, and play a role in psoriasis and AD. Th22 cells produce IL-22 that activates epithelial cells and mediates acanthosis in psoriasis and AD. On the other hand, Foxp3+ Treg cells attenuate immune responses partly via TGF-β or IL-10. Tissue resident memory T (Trm) cells in the skin-most of which are epidermal CD8T cells-constitute the first line of the defense against repeated infections. CD8 T cells are also engaged in psoriasis, lichen planus, and drug eruptions. Skin harbors innate-like αβT cells such as natural killer T (NKT) cells as well, whose function is not fully revealed. Understanding these αβT cells helps to comprehend skin diseases."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326211541120","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60346054"},{"@type":"NRID","@value":"1000060346054"}],"foaf:name":[{"@value":"Takashi Nomura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444178805632","@type":"Researcher","foaf:name":[{"@value":"Kenji Kabashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444178805505","@type":"Researcher","foaf:name":[{"@value":"Yoshiki Miyachi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09231811"}],"prism:publicationName":[{"@value":"Journal of Dermatological Science"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2014-10","prism:volume":"76","prism:number":"1","prism:startingPage":"3","prism:endingPage":"9"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/3.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0923181114001832?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0923181114001832?httpAccept=text/plain"}],"createdAt":"2014-08-12","modifiedAt":"2025-10-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Keratinocytes","dc:title":"Keratinocytes"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes","dc:title":"T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatology","dc:title":"Dermatology"},{"@id":"https://cir.nii.ac.jp/all?q=CD8-Positive%20T-Lymphocytes","dc:title":"CD8-Positive T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Memory%20T%20cells","dc:title":"Memory T cells"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatitis,%20Atopic","dc:title":"Dermatitis, Atopic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Th2%20Cells","dc:title":"Th2 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Transforming%20Growth%20Factor%20beta","dc:title":"Transforming Growth Factor beta"},{"@id":"https://cir.nii.ac.jp/all?q=Hypersensitivity","dc:title":"Hypersensitivity"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=CD8T%20cells","dc:title":"CD8T cells"},{"@id":"https://cir.nii.ac.jp/all?q=CD4T%20cells","dc:title":"CD4T cells"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Innate-like%20T%20cells.","dc:title":"Innate-like T cells."},{"@id":"https://cir.nii.ac.jp/all?q=Skin","dc:title":"Skin"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Membrane","dc:title":"Cell Membrane"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-17","dc:title":"Interleukin-17"},{"@id":"https://cir.nii.ac.jp/all?q=Lichen%20Planus","dc:title":"Lichen Planus"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Forkhead%20Transcription%20Factors","dc:title":"Forkhead Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Regulatory%20T%20cells","dc:title":"Regulatory T cells"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes,%20Helper-Inducer","dc:title":"T-Lymphocytes, Helper-Inducer"},{"@id":"https://cir.nii.ac.jp/all?q=Th1%20Cells","dc:title":"Th1 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-10","dc:title":"Interleukin-10"},{"@id":"https://cir.nii.ac.jp/all?q=Killer%20Cells,%20Natural","dc:title":"Killer Cells, Natural"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Eruptions","dc:title":"Drug Eruptions"},{"@id":"https://cir.nii.ac.jp/all?q=Skin%20T%20cells","dc:title":"Skin T cells"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782214394240","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24591649"},{"@type":"JGN","@value":"JP24591649"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591649/"}],"notation":[{"@language":"ja","@value":"制御性Ｔ細胞サブセットによる皮膚免疫制御"},{"@language":"en","@value":"Regulation of skin immunity by regulatory T 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