{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002216049007232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.jtcvs.2013.09.050"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022522313011471?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022522313011471?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"24267779"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Impact and predictors of acute exacerbation of interstitial lung diseases after pulmonary resection for lung cancer"}],"description":[{"notation":[{"@value":"The study objective was to examine the incidence, risk factors, and mortality rate of acute exacerbation of interstitial lung diseases in patients with lung cancer undergoing pulmonary resection in a large-scale multi-institutional cohort.We retrospectively analyzed 1763 patients with non-small cell lung cancer who had undergone pulmonary resection and presented with a clinical diagnosis of interstitial lung diseases between January 2000 and December 2009 at 61 hospitals in Japan. The incidence and outcomes of acute exacerbation within 30 days from the operation were investigated. Univariate and multivariate logistic regression analyses were used to identify independent risk factors of acute exacerbation.Acute exacerbation occurred in 164 patients (9.3%; 95% confidence interval, 8.0-10.8), with a mortality rate of 43.9%, and was the top cause of 30-day mortality (71.7%). The following 7 independent risk factors of acute exacerbation were identified: surgical procedures, male sex, history of exacerbation, preoperative steroid use, serum sialylated carbohydrate antigen KL-6 levels, usual interstitial pneumonia appearance on computed tomography scan, and reduced percent predicted vital capacity. Surgical procedures showed the strongest association with acute exacerbation (using wedge resection as the reference, lobectomy or segmentectomy: odds ratio, 3.83; 95% confidence interval, 1.94-7.57; bi-lobectomy or pneumonectomy: odds ratio, 5.70; 95% confidence interval, 2.38-13.7; P  .001). The effect of perioperative prophylactics, such as steroids and sivelestat, was not confirmed in this study.Pulmonary resection for patients with lung cancer with interstitial lung diseases may provoke acute exacerbation at a substantially high rate and has high associated mortality. Surgical procedures that proved to be a risk factor for acute exacerbation should be chosen cautiously for these high-risk patients."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566394176315271","@type":"Researcher","foaf:name":[{"@value":"Toshihiko Sato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315264","@type":"Researcher","foaf:name":[{"@value":"Satoshi Teramukai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315277","@type":"Researcher","foaf:name":[{"@value":"Haruhiko Kondo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315265","@type":"Researcher","foaf:name":[{"@value":"Atsushi Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315270","@type":"Researcher","foaf:name":[{"@value":"Masahito Ebina"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315273","@type":"Researcher","foaf:name":[{"@value":"Kazuma Kishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315275","@type":"Researcher","foaf:name":[{"@value":"Yoshitaka Fujii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315276","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Mitsudomi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315272","@type":"Researcher","foaf:name":[{"@value":"Masahiro Yoshimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315268","@type":"Researcher","foaf:name":[{"@value":"Tomohiro Maniwa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315266","@type":"Researcher","foaf:name":[{"@value":"Kenji Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315267","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Kataoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315274","@type":"Researcher","foaf:name":[{"@value":"Yukihiko Sugiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315269","@type":"Researcher","foaf:name":[{"@value":"Takashi Kondo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394176315278","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Date"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00225223"}],"prism:publicationName":[{"@value":"The Journal of Thoracic and Cardiovascular Surgery"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2014-05","prism:volume":"147","prism:number":"5","prism:startingPage":"1604","prism:endingPage":"1611.e3"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0022522313011471?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0022522313011471?httpAccept=text/plain"}],"createdAt":"2013-11-21","modifiedAt":"2018-10-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Pulmonary%20and%20Respiratory%20Medicine","dc:title":"Pulmonary and Respiratory Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Neoplasms","dc:title":"Lung Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Non-Small-Cell%20Lung","dc:title":"Carcinoma, Non-Small-Cell Lung"},{"@id":"https://cir.nii.ac.jp/all?q=Odds%20Ratio","dc:title":"Odds Ratio"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Pneumonectomy","dc:title":"Pneumonectomy"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Retrospective%20Studies","dc:title":"Retrospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Incidence","dc:title":"Incidence"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Logistic%20Models","dc:title":"Logistic Models"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Multivariate%20Analysis","dc:title":"Multivariate Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Progression","dc:title":"Disease Progression"},{"@id":"https://cir.nii.ac.jp/all?q=Surgery","dc:title":"Surgery"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiology%20and%20Cardiovascular%20Medicine","dc:title":"Cardiology and Cardiovascular Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Diseases,%20Interstitial","dc:title":"Lung Diseases, Interstitial"},{"@id":"https://cir.nii.ac.jp/all?q=Tomography,%20X-Ray%20Computed","dc:title":"Tomography, X-Ray Computed"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782192147072","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24240042"},{"@type":"JGN","@value":"JP24240042"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24240042/"}],"notation":[{"@language":"ja","@value":"先端医療技術の開発における臨床試験の計画と統計解析に関する研究"},{"@language":"en","@value":"Design and statistical analysis in translational clinical trials"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282677611372416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78 594 patients during 2014-2015"},{"@value":"Model of lung cancer surgery risk derived from a Japanese nationwide web-based 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