{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002216611112960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.langmuir.5b00351"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.5b00351"}},{"identifier":{"@type":"PMID","@value":"25719761"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Molecular Interaction Forces Generated during Protein Adsorption to Well-Defined Polymer Brush Surfaces"}],"description":[{"notation":[{"@value":"The molecular interaction forces generated during the adsorption of proteins to surfaces were examined by the force-versus-distance (f-d) curve measurements of atomic force microscopy using probes modified with appropriate molecules. Various substrates with polymer brush layers bearing zwitterionic, cationic, anionic, and hydrophobic groups were systematically prepared by surface-initiated atom transfer radical polymerization. Surface interaction forces on these substrates were analyzed by the f-d curve measurements using probes with the same polymer brush layer as the substrate. Repulsive forces, which decreased depending on the ionic strength, were generated between cationic or anionic polyelectrolyte brush layers; these were considered to be electrostatic interaction forces. A strong adhesive force was detected between hydrophobic polymer brush layers during retraction; this corresponded to the hydrophobic interaction between two hydrophobic polymer layers. In contrast, no significant interaction forces were detected between zwitterionic polymer brush layers. Direct interaction forces between proteins and polymer brush layers were then quantitatively evaluated by the f-d curve measurements using protein-immobilized probes consisting of negatively charged albumin and positively charged lysozyme under physiological conditions. In addition, the amount of protein adsorbed on the polymer brush layer was quantified by surface plasmon resonance measurements. Relatively large amounts of protein adsorbed to the polyelectrolyte brush layers with opposite charges. It was considered that the detachment of the protein after contact with the polymer brush layer hardly occurred due to salt formation at the interface. Both proteins adsorbed significantly on the hydrophobic polymer brush layer, which was due to hydrophobic interactions at the interface. In contrast, the zwitterionic polymer brush layer exhibited no significant interaction force with proteins and suppressed protein adsorption. Taken together, our results suggest that to obtain the protein-repellent surfaces, the surface should not induce direct interaction forces with proteins after contact with them."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566394750328960","@type":"Researcher","foaf:name":[{"@value":"Sho Sakata"}],"jpcoar:affiliationName":[{"@value":"Department of Materials Engineering and ‡Department of\rBioengineering, School\rof Engineering, The University of Tokyo 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658307351809","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40402789"},{"@type":"NRID","@value":"1000040402789"},{"@type":"NRID","@value":"9000315143950"},{"@type":"NRID","@value":"9000240243826"},{"@type":"NRID","@value":"9000403161953"},{"@type":"NRID","@value":"9000251392049"},{"@type":"NRID","@value":"9000017678042"},{"@type":"NRID","@value":"9000315144000"},{"@type":"NRID","@value":"9000018617182"},{"@type":"NRID","@value":"9000392023496"},{"@type":"NRID","@value":"9000365559210"},{"@type":"NRID","@value":"9000283716434"},{"@type":"NRID","@value":"9000383166721"},{"@type":"NRID","@value":"9000383165589"},{"@type":"NRID","@value":"9000283716640"},{"@type":"NRID","@value":"9000299561458"},{"@type":"NRID","@value":"9000258712691"},{"@type":"NRID","@value":"9000024970468"},{"@type":"NRID","@value":"9000389552956"},{"@type":"NRID","@value":"9000010268447"}],"foaf:name":[{"@value":"Yuuki 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Ishihara"}],"jpcoar:affiliationName":[{"@value":"Department of Materials Engineering and ‡Department of\rBioengineering, School\rof Engineering, The University of Tokyo 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07437463"},{"@type":"EISSN","@value":"15205827"}],"prism:publicationName":[{"@value":"Langmuir"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2015-03-04","prism:volume":"31","prism:number":"10","prism:startingPage":"3108","prism:endingPage":"3114"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.5b00351"}],"createdAt":"2015-02-27","modifiedAt":"2023-04-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Polymers","dc:title":"Polymers"},{"@id":"https://cir.nii.ac.jp/all?q=Surface%20Properties","dc:title":"Surface Properties"},{"@id":"https://cir.nii.ac.jp/all?q=Proteins","dc:title":"Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Atomic%20Force","dc:title":"Microscopy, Atomic Force"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Adsorption","dc:title":"Adsorption"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrophobic%20and%20Hydrophilic%20Interactions","dc:title":"Hydrophobic and Hydrophilic Interactions"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782140595200","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23107005"},{"@type":"JGN","@value":"JP23107005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23107005/"}],"notation":[{"@language":"ja","@value":"バイオ分子結合型細胞内分子輸送デバイス"},{"@language":"en","@value":"Transport nanodevice immobilized specific 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