{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002216664849536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/jm2014293"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/jm2014293"}},{"identifier":{"@type":"PMID","@value":"22185225"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Peroxisome Proliferator-Activated Receptors (PPARs) Have Multiple Binding Points That Accommodate Ligands in Various Conformations: Phenylpropanoic Acid-Type PPAR Ligands Bind to PPAR in Different Conformations, Depending on the Subtype"}],"description":[{"notation":[{"@value":"Human peroxisome proliferator-activated receptors (hPPARs) are ligand-dependent transcription factors that control various biological responses, and there are three subtypes: hPPARα, hPPARδ, and hPPARγ. We report here that α-substituted phenylpropanoic acid-type hPPAR agonists with similar structure bind to the hPPAR ligand binding domain (LBD) in different conformations, depending on the receptor subtype. These results might indicate that hPPAR ligand binding pockets have multiple binding points that can be utilized to accommodate structurally flexible hPPAR ligands."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030285133841779972","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70506253"},{"@type":"NRID","@value":"1000070506253"},{"@type":"NRID","@value":"9000006630153"},{"@type":"NRID","@value":"9000380473516"},{"@type":"NRID","@value":"9000391395460"},{"@type":"NRID","@value":"9000380473524"},{"@type":"NRID","@value":"9000365042783"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nkuwabara"}],"foaf:name":[{"@value":"Naoyuki Kuwabara"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical\rSciences, Faculty of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, 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565-0874,\rJapan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444851565188","@type":"Researcher","foaf:name":[{"@value":"Daisuke Tomioka"}],"jpcoar:affiliationName":[{"@value":"Graduate School of\rNanobioscience, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku,\rYokohama 230-0045, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444851565184","@type":"Researcher","foaf:name":[{"@value":"Masao Ohashi"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Medicine,\rDentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003444851565187","@type":"Researcher","foaf:name":[{"@value":"Junn Yanagisawa"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Life and\rEnvironmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki 305-8577, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326230312448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30273858"},{"@type":"NRID","@value":"1000030273858"},{"@type":"NRID","@value":"9000254713938"},{"@type":"NRID","@value":"9000020147623"},{"@type":"NRID","@value":"9000240040894"},{"@type":"NRID","@value":"9000252815650"},{"@type":"NRID","@value":"9000391952329"},{"@type":"NRID","@value":"9000398167712"},{"@type":"NRID","@value":"9000001129637"},{"@type":"NRID","@value":"9000004554972"},{"@type":"NRID","@value":"9000413482547"},{"@type":"NRID","@value":"9000406214601"},{"@type":"NRID","@value":"9000005160943"},{"@type":"NRID","@value":"9000241829280"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nana56"}],"foaf:name":[{"@value":"Toshiyuki Shimizu"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical\rSciences, Faculty of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, 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Miyachi"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Medicine,\rDentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00222623"},{"@type":"EISSN","@value":"15204804"}],"prism:publicationName":[{"@value":"Journal of Medicinal Chemistry"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2012-01-10","prism:volume":"55","prism:number":"2","prism:startingPage":"893","prism:endingPage":"902"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/jm2014293"}],"createdAt":"2011-12-19","modifiedAt":"2023-04-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Molecular","dc:title":"Models, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Binding%20Sites","dc:title":"Binding 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