{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002216804466176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ncomms8464"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms8464.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms8464"}},{"identifier":{"@type":"PMID","@value":"26108163"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Interleukin-17 (IL-17)-producing γδ T (γδ17) cells have been implicated in inflammatory diseases, but the underlying pathogenic mechanisms remain unclear. Here, we show that both CD4<jats:sup>+</jats:sup> and γδ17 cells are required for the development of autoimmune arthritis in IL-1 receptor antagonist (IL-1Ra)-deficient mice. Specifically, activated CD4<jats:sup>+</jats:sup> T cells direct γδ T-cell infiltration by inducing CCL2 expression in joints. Furthermore, IL-17 reporter mice reveal that the Vγ6<jats:sup>+</jats:sup> subset of CCR2<jats:sup>+</jats:sup> γδ T cells preferentially produces IL-17 in inflamed joints. Importantly, because IL-1Ra normally suppresses IL-1R expression on γδ T cells, IL-1Ra-deficient mice exhibit elevated IL-1R expression on Vγ6<jats:sup>+</jats:sup> cells, which play a critical role in inducing them to produce IL-17. Our findings demonstrate a pathogenic mechanism in which adaptive and innate immunity induce an autoimmune disease in a coordinated manner.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380284919971235977","@type":"Researcher","foaf:name":[{"@value":"Aoi Akitsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235974","@type":"Researcher","foaf:name":[{"@value":"Harumichi Ishigame"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235971","@type":"Researcher","foaf:name":[{"@value":"Shigeru Kakuta"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285300695926913","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40712443"},{"@type":"NRID","@value":"1000040712443"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shchung"}],"foaf:name":[{"@value":"Soo-hyun Chung"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235968","@type":"Researcher","foaf:name":[{"@value":"Satoshi Ikeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235976","@type":"Researcher","foaf:name":[{"@value":"Kenji Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235973","@type":"Researcher","foaf:name":[{"@value":"Sachiko Kubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235975","@type":"Researcher","foaf:name":[{"@value":"Yang Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276190489984","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90359985"},{"@type":"NRID","@value":"1000090359985"},{"@type":"NRID","@value":"9000002056649"},{"@type":"NRID","@value":"9000414491145"},{"@type":"NRID","@value":"9000001958829"},{"@type":"NRID","@value":"9000001303265"},{"@type":"NRID","@value":"9000009993380"},{"@type":"NRID","@value":"9000023282096"},{"@type":"NRID","@value":"9000313194858"},{"@type":"NRID","@value":"9000401947593"},{"@type":"NRID","@value":"9000326649336"},{"@type":"NRID","@value":"9000381069797"},{"@type":"NRID","@value":"9000023070851"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0110731"}],"foaf:name":[{"@value":"Masayuki Umemura"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326208052864","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30229455"},{"@type":"NRID","@value":"1000030229455"},{"@type":"NRID","@value":"9000002056646"},{"@type":"NRID","@value":"9000004643482"},{"@type":"NRID","@value":"9000414491151"},{"@type":"NRID","@value":"9000380125651"},{"@type":"NRID","@value":"9000001303273"},{"@type":"NRID","@value":"9000010969243"},{"@type":"NRID","@value":"9000006810762"},{"@type":"NRID","@value":"9000007594611"},{"@type":"NRID","@value":"9000406393740"},{"@type":"NRID","@value":"9000362204247"},{"@type":"NRID","@value":"9000326649337"},{"@type":"NRID","@value":"9000005706709"},{"@type":"NRID","@value":"9000001498639"},{"@type":"NRID","@value":"9000381069796"},{"@type":"NRID","@value":"9000000683471"},{"@type":"NRID","@value":"9000020544156"},{"@type":"NRID","@value":"9000241625117"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0158648"}],"foaf:name":[{"@value":"Goro Matsuzaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284919971235969","@type":"Researcher","foaf:name":[{"@value":"Yasunobu Yoshikai"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276165065344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60396877"},{"@type":"NRID","@value":"1000060396877"},{"@type":"NRID","@value":"9000003749089"},{"@type":"NRID","@value":"9000243880589"},{"@type":"NRID","@value":"9000347321595"},{"@type":"NRID","@value":"9000403262004"},{"@type":"NRID","@value":"9000403438910"},{"@type":"NRID","@value":"9000415311194"},{"@type":"NRID","@value":"9000241736583"},{"@type":"NRID","@value":"9000411810112"},{"@type":"NRID","@value":"9000412086442"},{"@type":"NRID","@value":"9000333083727"},{"@type":"NRID","@value":"9000412582759"},{"@type":"NRID","@value":"9000391773570"},{"@type":"NRID","@value":"9000314078923"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/_saijo"}],"foaf:name":[{"@value":"Shinobu 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Iwakura"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2015-06-25","prism:volume":"6","prism:number":"1","prism:startingPage":"7464"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/ncomms8464.pdf"},{"@id":"https://www.nature.com/articles/ncomms8464"}],"createdAt":"2015-06-25","modifiedAt":"2023-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Interleukin-1%20Type%20I","dc:title":"Receptors, Interleukin-1 Type I"},{"@id":"https://cir.nii.ac.jp/all?q=Arthritis","dc:title":"Arthritis"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-17","dc:title":"Interleukin-17"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Antigen,%20T-Cell,%20gamma-delta","dc:title":"Receptors, Antigen, T-Cell, gamma-delta"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Autoimmune%20Diseases","dc:title":"Autoimmune Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin%201%20Receptor%20Antagonist%20Protein","dc:title":"Interleukin 1 Receptor Antagonist Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocyte%20Subsets","dc:title":"T-Lymphocyte Subsets"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Joints","dc:title":"Joints"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokine%20CCL2","dc:title":"Chemokine CCL2"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782191433728","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24220011"},{"@type":"JGN","@value":"JP24220011"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24220011/"}],"notation":[{"@language":"ja","@value":"創薬標的の探索を目指したＩＬ－１関連遺伝子改変マウスライブラリーの作製と解析"},{"@language":"en","@value":"Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782245591680","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25293105"},{"@type":"JGN","@value":"JP25293105"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293105/"}],"notation":[{"@language":"ja","@value":"結核菌肺感染局所へのT細胞ターゲッティング機構の解明と新規ワクチン開発への応用"},{"@language":"en","@value":"Analysis of mechanism of T cell targeting into Mycobacterium tuberculosis-infected lung and development of new lung-targeting vaccine strategy"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782482981504","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H05787"},{"@type":"JGN","@value":"JP15H05787"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05787/"}],"notation":[{"@language":"ja","@value":"免疫系の制御による生体恒常性維持システムの解明と疾患の予防・治療基盤の確立"},{"@language":"en","@value":"Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256826059776","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K08468"},{"@type":"JGN","@value":"JP15K08468"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08468/"}],"notation":[{"@language":"ja","@value":"肺結核におけるIL-17ファミリー依存性免疫応答ならびにその防御機構の解明"},{"@language":"en","@value":"Involvement of IL-17 cytokine family in protective immunity to pulmonary mycobacterial infection."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257265648640","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26293094"},{"@type":"JGN","@value":"JP26293094"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293094/"}],"notation":[{"@language":"ja","@value":"真菌感染防御機構の分子基盤"},{"@language":"en","@value":"Anti-fungal Immunity"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234610838144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two Types of Interleukin 17A–Producing γδ T Cells in Protection Against Pulmonary Infection With<i>Klebsiella pneumoniae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235533936256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin‐17‐producing <i>γδ</i> T (<i>γδ</i>17) cells in inflammatory diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142551205120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vγ6\n                    <sup>+</sup>\n                    γδ T cells are critical for protection against infection by\n                    <i>Escherichia coli in 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antagonist-deficient mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707167731200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711706893568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guérin via induction of apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714857528704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618926021888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RelA and RelB Transcription Factors in Distinct Thymocyte Populations Control Lymphotoxin-Dependent Interleukin-17 Production in γδ T Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302474811916672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Changes in the molecular profiles of large-vessel vasculitis treated with biological disease-modifying anti-rheumatic drugs and Janus kinase inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165426521216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Osteoimmunology in Bone Fracture Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165805738368","@type":"Article","resourceType":"学術雑誌論文(journal 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