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Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
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- Yu Lei
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
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- Naozumi Ishimaru
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
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- Takashi Nagasawa
- Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan 4
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- Michael R. Bösl
- Transgenic Core Facility, Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany 6
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- Lukas T. Jeker
- Laboratory of Pediatric Immunology, Center for Biomedicine, University of Basel and The University Children’s Hospital of Basel, 4058 Basel, Switzerland 5
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- Izumi Ohigashi
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
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- Adiratna Mat Ripen
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
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- Rene de Waal Malefyt
- Merck Research Laboratories, Palo Alto, CA 94304 7
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- Takeshi Nitta
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
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- Georg A. Holländer
- Laboratory of Pediatric Immunology, Center for Biomedicine, University of Basel and The University Children’s Hospital of Basel, 4058 Basel, Switzerland 5
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- Yousuke Takahama
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
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- Yoshio Hayashi
- Division of Experimental Immunology, Institute for Genome Research 1 , 2
Bibliographic Information
- Published
- 2011-02-07
- Resource Type
- journal article
- DOI
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- 10.1084/jem.20102327
- 10.5451/unibas-ep29974
- Publisher
- Rockefeller University Press
Search this article
Description
<jats:p>Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show that the chemokine receptor XCR1 is expressed by tDCs, whereas medullary thymic epithelial cells (mTECs) express the ligand XCL1. XCL1-deficient mice are defective in the medullary accumulation of tDCs and the thymic generation of naturally occurring regulatory T cells (nT reg cells). Thymocytes from XCL1-deficient mice elicit dacryoadenitis in nude mice. mTEC expression of XCL1, tDC medullary accumulation, and nT reg cell generation are diminished in Aire-deficient mice. These results indicate that the XCL1-mediated medullary accumulation of tDCs contributes to nT reg cell development and is regulated by Aire.</jats:p>
Journal
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- Journal of Experimental Medicine
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Journal of Experimental Medicine 208 (2), 383-394, 2011-02-07
Rockefeller University Press
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Keywords
- Microscopy, Confocal
- Reverse Transcriptase Polymerase Chain Reaction
- Chemotaxis
- Fluorescent Antibody Technique
- Mice, Nude
- AIRE Protein
- Dendritic Cells
- Thymus Gland
- Flow Cytometry
- T-Lymphocytes, Regulatory
- Article
- Chemokines, C
- Dacryocystitis
- Mice
- Self Tolerance
- Image Processing, Computer-Assisted
- Animals
- Chemokines
- Transcription Factors
Details 詳細情報について
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- CRID
- 1360002217388900224
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- NII Article ID
- 10030199800
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- ISSN
- 15409538
- 00221007
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- PubMed
- 21300913
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- Article Type
- journal article
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- Data Source
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- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
