{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360002217477131776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/ars.2017.7336"}},{"identifier":{"@type":"URI","@value":"https://www.liebertpub.com/doi/full-xml/10.1089/ars.2017.7336"}},{"identifier":{"@type":"URI","@value":"https://www.liebertpub.com/doi/pdf/10.1089/ars.2017.7336"}},{"identifier":{"@type":"PMID","@value":"29631421"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"<i>In Vivo</i>\n                    Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging"}],"description":[{"notation":[{"@value":"Repeated use of nonsteroidal anti-inflammatory drugs can induce changes in the redox status, including production of reactive oxygen species (ROS), but the specific details of these changes remain unknown. Overhauser-enhanced magnetic resonance imaging (OMRI) has been used in vivo to monitor the redox status in several diseases and map tissue oxygen concentrations. We monitored the intra- and extracellular redox status in the stomach of rats with indomethacin-induced gastric ulcers using OMRI and investigated the relationship with gastric mucosal damage.One hour after oral administration of indomethacin (30 mg/kg), OMRI measurements in the stomach were made following nitroxyl probe administration. OMRI with the membrane-permeable nitroxyl probe, 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPOL), demonstrated a redox change toward oxidation, which was reversed by a membrane-permeable antioxidant. Conversely, imaging with the impermeable probe, 4-trimethylammonium-2,2,6,6-tetramethyl-piperidine-1-oxyl (CAT-1), demonstrated little redox change. Redox imbalance imaging of a live rat stomach with indomethacin-induced gastric ulcers was produced by dual imaging ofOMRI combined with a dual probe is a less invasive imaging technique for evaluation of intracellular ROS production contributing to the formation of gastric ulcers in the stomach of indomethacin-treated rats, which cannot be done with other methods.This method may be a very powerful tool for characterizing the pathogenesis of various diseases and may have medical applications."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380284920661320451","@type":"Researcher","foaf:name":[{"@value":"Keiji Yasukawa"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Advanced Pharmacology, Daiichi University of Pharmacy, Fukuoka, Japan."},{"@value":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan."},{"@value":"Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320321","@type":"Researcher","foaf:name":[{"@value":"Ryota Shigemi"}],"jpcoar:affiliationName":[{"@value":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320450","@type":"Researcher","foaf:name":[{"@value":"Tomomi Kanbe"}],"jpcoar:affiliationName":[{"@value":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320320","@type":"Researcher","foaf:name":[{"@value":"Yusaku Mutsumoto"}],"jpcoar:affiliationName":[{"@value":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320448","@type":"Researcher","foaf:name":[{"@value":"Fumiko Oda"}],"jpcoar:affiliationName":[{"@value":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320449","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro Ichikawa"}],"jpcoar:affiliationName":[{"@value":"Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320322","@type":"Researcher","foaf:name":[{"@value":"Ken-Ichi Yamada"}],"jpcoar:affiliationName":[{"@value":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320324","@type":"Researcher","foaf:name":[{"@value":"Xin Tun"}],"jpcoar:affiliationName":[{"@value":"Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380284920661320323","@type":"Researcher","foaf:name":[{"@value":"Hideo Utsumi"}],"jpcoar:affiliationName":[{"@value":"School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15230864"},{"@type":"EISSN","@value":"15577716"}],"prism:publicationName":[{"@value":"Antioxidants & Redox Signaling"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2019-03-20","prism:volume":"30","prism:number":"9","prism:startingPage":"1147","prism:endingPage":"1161"},"reviewed":"false","dc:rights":["https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/"],"url":[{"@id":"https://www.liebertpub.com/doi/full-xml/10.1089/ars.2017.7336"},{"@id":"https://www.liebertpub.com/doi/pdf/10.1089/ars.2017.7336"}],"createdAt":"2018-04-10","modifiedAt":"2026-02-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Spectroscopy","dc:title":"Magnetic Resonance Spectroscopy"},{"@id":"https://cir.nii.ac.jp/all?q=Pyrrolidines","dc:title":"Pyrrolidines"},{"@id":"https://cir.nii.ac.jp/all?q=Indomethacin","dc:title":"Indomethacin"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Imaging","dc:title":"Molecular Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclic%20N-Oxides","dc:title":"Cyclic N-Oxides"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Nitrogen%20Oxides","dc:title":"Nitrogen Oxides"},{"@id":"https://cir.nii.ac.jp/all?q=Spin%20Labels","dc:title":"Spin Labels"},{"@id":"https://cir.nii.ac.jp/all?q=Stomach%20Ulcer","dc:title":"Stomach Ulcer"},{"@id":"https://cir.nii.ac.jp/all?q=Reactive%20Oxygen%20Species","dc:title":"Reactive Oxygen Species"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidation-Reduction","dc:title":"Oxidation-Reduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781900662656","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H05113"},{"@type":"JGN","@value":"JP16H05113"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05113/"}],"notation":[{"@language":"ja","@value":"新規臨床用ラジカルイメージング装置開発に向けた非臨床基礎研究"},{"@language":"en","@value":"Studies on the Development of Clinical Free Radical Imaging Systme"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781993911936","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H03526"},{"@type":"JGN","@value":"JP18H03526"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03526/"}],"notation":[{"@language":"ja","@value":"代謝動態計測のための新たな動的核偏極MRI開発および実証研究"},{"@language":"en","@value":"Development of dynamic nuclear polarization MRI for metabolic dynamics 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Theranostics of Gastric Ulcers Using Nitroxyl Radicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043481252096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043699176704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046130108928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412891754776832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Radiation-induced redox alteration in 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